Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Judith R. Homberg; Evan J. Kyzar; Michael Nguyen; William H. Norton; Julian Pittman; Manoj K. Poudel; Siddharth Gaikwad; Shun Nakamura; Mamiko Koshiba; Hideo Yamanouchi; Maria Luisa Scattoni; Jeremy F.P. Ullman; David M. Diamond; Aleksandra A. Kaluyeva; Matthew O. Parker; Victor M. Klimenko; Sergey A. Apryatin; Richard E. Brown; Cai Song; Raul R. Gainetdinov; Irving I. Gottesman; Allan V. Kalueff

doi:10.1016/j.neubiorev.2016.03.013

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Judith R. Homberg, Evan J. Kyzar, Michael Nguyen, William H. Norton, Julian Pittman, Manoj K. Poudel, Siddharth Gaikwad, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Maria Luisa Scattoni, Jeremy F.P. Ullman, David M. Diamond, Aleksandra A. Kaluyeva, Matthew O. Parker, Victor M. Klimenko, Sergey A. Apryatin, Richard E. Brown, Cai Song, Raul R. GainetdinovIrving I. Gottesman, Allan V. Kalueff

Institute of Life Sciences and Healthcare

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Abstract

Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

Original language	English
Pages (from-to)	292-312
Journal	Neuroscience and Biobehavioral Reviews
Volume	65
Early online date	2 Apr 2016
DOIs	https://doi.org/10.1016/j.neubiorev.2016.03.013
Publication status	Published - Jun 2016

Keywords

Neurodevelopmental disorder
Model organism
Experimental model
Preclinical study
Translational research

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Understanding autism and other neurodevelopmental disordersAccepted author manuscript (Post-print), 1.03 MBLicence: CC BY-NC-ND

http://linkinghub.elsevier.com/retrieve/pii/S0149763415301378

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Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W. H., Pittman, J., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., Scattoni, M. L., Ullman, J. F. P., Diamond, D. M., Kaluyeva, A. A., Parker, M. O., Klimenko, V. M., Apryatin, S. A., Brown, R. E., Song, C., ... Kalueff, A. V. (2016). Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. Neuroscience and Biobehavioral Reviews, 65, 292-312. https://doi.org/10.1016/j.neubiorev.2016.03.013

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title = "Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models",

abstract = "Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.",

keywords = "Neurodevelopmental disorder, Model organism, Experimental model, Preclinical study, Translational research",

author = "Homberg, {Judith R.} and Kyzar, {Evan J.} and Michael Nguyen and Norton, {William H.} and Julian Pittman and Poudel, {Manoj K.} and Siddharth Gaikwad and Shun Nakamura and Mamiko Koshiba and Hideo Yamanouchi and Scattoni, {Maria Luisa} and Ullman, {Jeremy F.P.} and Diamond, {David M.} and Kaluyeva, {Aleksandra A.} and Parker, {Matthew O.} and Klimenko, {Victor M.} and Apryatin, {Sergey A.} and Brown, {Richard E.} and Cai Song and Gainetdinov, {Raul R.} and Gottesman, {Irving I.} and Kalueff, {Allan V.}",

year = "2016",

month = jun,

doi = "10.1016/j.neubiorev.2016.03.013",

language = "English",

volume = "65",

pages = "292--312",

journal = "Neuroscience and Biobehavioral Reviews",

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Homberg, JR, Kyzar, EJ, Nguyen, M, Norton, WH, Pittman, J, Poudel, MK, Gaikwad, S, Nakamura, S, Koshiba, M, Yamanouchi, H, Scattoni, ML, Ullman, JFP, Diamond, DM, Kaluyeva, AA, Parker, MO, Klimenko, VM, Apryatin, SA, Brown, RE, Song, C, Gainetdinov, RR, Gottesman, II & Kalueff, AV 2016, 'Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models', Neuroscience and Biobehavioral Reviews, vol. 65, pp. 292-312. https://doi.org/10.1016/j.neubiorev.2016.03.013

TY - JOUR

T1 - Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

AU - Homberg, Judith R.

AU - Kyzar, Evan J.

AU - Nguyen, Michael

AU - Norton, William H.

AU - Pittman, Julian

AU - Poudel, Manoj K.

AU - Gaikwad, Siddharth

AU - Nakamura, Shun

AU - Koshiba, Mamiko

AU - Yamanouchi, Hideo

AU - Scattoni, Maria Luisa

AU - Ullman, Jeremy F.P.

AU - Diamond, David M.

AU - Kaluyeva, Aleksandra A.

AU - Parker, Matthew O.

AU - Klimenko, Victor M.

AU - Apryatin, Sergey A.

AU - Brown, Richard E.

AU - Song, Cai

AU - Gainetdinov, Raul R.

AU - Gottesman, Irving I.

AU - Kalueff, Allan V.

PY - 2016/6

Y1 - 2016/6

N2 - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

AB - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

KW - Neurodevelopmental disorder

KW - Model organism

KW - Experimental model

KW - Preclinical study

KW - Translational research

U2 - 10.1016/j.neubiorev.2016.03.013

DO - 10.1016/j.neubiorev.2016.03.013

M3 - Article

SN - 0149-7634

VL - 65

SP - 292

EP - 312

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

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Keywords

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