Use of cluster analysis to characterize patterns of sensitization in childhood allergy

Carina Venter; Kate Maslin; Hongmei Zhang; Akhilesh Kaushal; William Terry; Veeresh K Patil; Tara Dean; Syed Hasan Arshad

doi:10.1111/pai.12925

Use of cluster analysis to characterize patterns of sensitization in childhood allergy

Carina Venter, Kate Maslin, Hongmei Zhang, Akhilesh Kaushal, William Terry, Veeresh K Patil, Tara Dean, Syed Hasan Arshad

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Abstract

Multiple tests are available to determine food and aero‐allergen sensitization (1,2), but it is unclear if distinct sensitization patterns can be determined by using a combination of three testing modalities; skin prick test (SPT), specific IgE test and component resolved diagnostic tests to characterize or identify certain clinical phenotypes. This is a novel paper utilizing sensitization clusters (SPT, specific IgE tests and component resolved diagnostics) in an unselected cohort of 10/11 year‐old children and its association with asthma, eczema, rhinitis and IgE‐mediated food allergy. A birth cohort recruited in 2001 (Isle of Wight), was followed up prospectively to 10 years of age (3) (n = 827).

Original language	English
Pages (from-to)	644-648
Number of pages	5
Journal	Pediatric Allergy and Immunology
Volume	29
Issue number	6
Early online date	26 May 2018
DOIs	https://doi.org/10.1111/pai.12925
Publication status	Published - 1 Sept 2018

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This is the peer reviewed version of the following article: Venter, C. , Maslin, K. , Zhang, H. , Kaushal, A. , Terry, W. , Patil, V. K., Dean, T. and Arshad, S. H. (2018), Use of cluster analysis to characterize patterns of sensitization in childhood allergy. Pediatr Allergy Immunol. Accepted Author Manuscript. . doi:10.1111/pai.12925, which has been published in final form at https://doi.org/10.1111/pai.12925. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Accepted author manuscript (Post-print), 691 KB

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title = "Use of cluster analysis to characterize patterns of sensitization in childhood allergy",

abstract = "Multiple tests are available to determine food and aero‐allergen sensitization (1,2), but it is unclear if distinct sensitization patterns can be determined by using a combination of three testing modalities; skin prick test (SPT), specific IgE test and component resolved diagnostic tests to characterize or identify certain clinical phenotypes. This is a novel paper utilizing sensitization clusters (SPT, specific IgE tests and component resolved diagnostics) in an unselected cohort of 10/11 year‐old children and its association with asthma, eczema, rhinitis and IgE‐mediated food allergy. A birth cohort recruited in 2001 (Isle of Wight), was followed up prospectively to 10 years of age (3) (n = 827).",

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T1 - Use of cluster analysis to characterize patterns of sensitization in childhood allergy

AU - Venter, Carina

AU - Maslin, Kate

AU - Zhang, Hongmei

AU - Kaushal, Akhilesh

AU - Terry, William

AU - Patil, Veeresh K

AU - Dean, Tara

AU - Arshad, Syed Hasan

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N2 - Multiple tests are available to determine food and aero‐allergen sensitization (1,2), but it is unclear if distinct sensitization patterns can be determined by using a combination of three testing modalities; skin prick test (SPT), specific IgE test and component resolved diagnostic tests to characterize or identify certain clinical phenotypes. This is a novel paper utilizing sensitization clusters (SPT, specific IgE tests and component resolved diagnostics) in an unselected cohort of 10/11 year‐old children and its association with asthma, eczema, rhinitis and IgE‐mediated food allergy. A birth cohort recruited in 2001 (Isle of Wight), was followed up prospectively to 10 years of age (3) (n = 827).

AB - Multiple tests are available to determine food and aero‐allergen sensitization (1,2), but it is unclear if distinct sensitization patterns can be determined by using a combination of three testing modalities; skin prick test (SPT), specific IgE test and component resolved diagnostic tests to characterize or identify certain clinical phenotypes. This is a novel paper utilizing sensitization clusters (SPT, specific IgE tests and component resolved diagnostics) in an unselected cohort of 10/11 year‐old children and its association with asthma, eczema, rhinitis and IgE‐mediated food allergy. A birth cohort recruited in 2001 (Isle of Wight), was followed up prospectively to 10 years of age (3) (n = 827).

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JO - Pediatric Allergy and Immunology

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Use of cluster analysis to characterize patterns of sensitization in childhood allergy

Abstract

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