TY - JOUR
T1 - Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery
T2 - synthesis and evaluation
AU - Barbu, Eugen
AU - Sarvaiya, Indrajeetsinh
AU - Green, Keith L
AU - Nevell, Thomas G
AU - Tsibouklis, John
PY - 2005/9/15
Y1 - 2005/9/15
N2 - Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N′-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.
AB - Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N′-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.
U2 - 10.1002/jbm.a.v74a:4
DO - 10.1002/jbm.a.v74a:4
M3 - Article
SN - 1549-3296
VL - 74A
SP - 598
EP - 606
JO - Journal of Biomedical Materials Research Part A
JF - Journal of Biomedical Materials Research Part A
IS - 4
ER -