Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation

Eugen Barbu, Indrajeetsinh Sarvaiya, Keith L Green, Thomas G Nevell, John Tsibouklis

Research output: Contribution to journalArticlepeer-review

Abstract

Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N′-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.
Original languageEnglish
Pages (from-to)598-606
JournalJournal of Biomedical Materials Research Part A
Volume74A
Issue number4
DOIs
Publication statusPublished - 15 Sep 2005

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