TY - JOUR
T1 - Wnt6 marks sites of epithelial transformations in the chick embryo
AU - Schubert, Frank
AU - Mootoosamy, R.
AU - Walters, E.
AU - Graham, A.
AU - Tumiotto, L.
AU - Munsterberg, A.
AU - Lumsden, A.
AU - Dietrich, Susanne
PY - 2002
Y1 - 2002
N2 - In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chickWnt gene, chickWnt6. This gene encodes the first pan-epidermal Wnt signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial–mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling.
AB - In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chickWnt gene, chickWnt6. This gene encodes the first pan-epidermal Wnt signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial–mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling.
U2 - 10.1016/S0925-4773(02)00039-4
DO - 10.1016/S0925-4773(02)00039-4
M3 - Article
VL - 114
SP - 143
EP - 148
JO - Mechanisms of Development
JF - Mechanisms of Development
SN - 0925-4773
IS - 1-2
ER -