Zebrafish as a model of neurodevelopmental disorders

Murilo S. De Abreu; Rafael Genario; Ana C.V.V. Giacomini; Konstantin A. Demin; Anton M. Lakstygal; Tamara G. Amstislavskaya; Barbara Dotto Fontana; Matthew O. Parker; Allan V. Kalueff

doi:10.1016/j.neuroscience.2019.08.034

Zebrafish as a model of neurodevelopmental disorders

Murilo S. De Abreu, Rafael Genario, Ana C.V.V. Giacomini, Konstantin A. Demin, Anton M. Lakstygal, Tamara G. Amstislavskaya, Barbara Dotto Fontana, Matthew O. Parker, Allan V. Kalueff

Centre for Comparative & Evolutionary Psychology

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Abstract

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs with high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.

Original language	English
Journal	Neuroscience
Early online date	29 Aug 2019
DOIs	https://doi.org/10.1016/j.neuroscience.2019.08.034
Publication status	Early online - 29 Aug 2019

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Zebrafish as a Model of Neurodevelopmental DisordersAccepted author manuscript (Post-print), 501 KBLicence: CC BY-NC-ND

https://linkinghub.elsevier.com/retrieve/pii/S0306452219306074

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title = "Zebrafish as a model of neurodevelopmental disorders",

abstract = "Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs with high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.",

author = "{De Abreu}, {Murilo S.} and Rafael Genario and Giacomini, {Ana C.V.V.} and Demin, {Konstantin A.} and Lakstygal, {Anton M.} and Amstislavskaya, {Tamara G.} and Fontana, {Barbara Dotto} and Parker, {Matthew O.} and Kalueff, {Allan V.}",

year = "2019",

month = aug,

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doi = "10.1016/j.neuroscience.2019.08.034",

language = "English",

journal = "Neuroscience",

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T1 - Zebrafish as a model of neurodevelopmental disorders

AU - De Abreu, Murilo S.

AU - Genario, Rafael

AU - Giacomini, Ana C.V.V.

AU - Demin, Konstantin A.

AU - Lakstygal, Anton M.

AU - Amstislavskaya, Tamara G.

AU - Fontana, Barbara Dotto

AU - Parker, Matthew O.

AU - Kalueff, Allan V.

PY - 2019/8/29

Y1 - 2019/8/29

N2 - Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs with high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.

AB - Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs with high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.

U2 - 10.1016/j.neuroscience.2019.08.034

DO - 10.1016/j.neuroscience.2019.08.034

M3 - Article

SN - 0306-4522

JO - Neuroscience

JF - Neuroscience

ER -

Zebrafish as a model of neurodevelopmental disorders

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