Zebrafish models for attention deficit hyperactivity disorder (ADHD)

Barbara D. Fontana, Francini Franscescon, Denis B. Rosemberg, William H.J. Norton, Allan V. Kalueff, Matthew O. Parker

Research output: Contribution to journalReview articlepeer-review

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Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing rodent models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.
Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalNeuroscience and Biobehavioral Reviews
Early online date16 Feb 2019
Publication statusPublished - 1 May 2019


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