Amyloid-β oligomer dependent modulation of gastrointestinal contractility
: implications for dysmotility in Alzheimer’s Disease

  • Adina Georgette Gibbard

Student thesis: Doctoral Thesis

Abstract

At the outset of my PhD, my broad aims were to first characterise the expression of APP within the enteric nervous system (ENS) of wild-type (WT) animals, using immunohistochemistry (IHC). Following this, I then set out to characterise the expression of Aβ within the ENS of a transgenic model displaying an overexpression of amyloid precursor protein (APP) and subsequent increase in Aβ (APP-PSEN1 model). I then endeavoured to determine whether Alzheimer’s disease (AD) pathology, namely amyloid-β (Aβ), alters the expression of key neurotransmitter and inflammatory systems within the ENS, using the APP-PSEN1 model, and how these changes affect gastrointestinal (GI) functionality, in terms of colonic contractility and motility, expression of key neurotransmitter-related proteins involved in motility, and expression of genes related to inflammation. In addition, I sought to explore whether stress (acute- restraint stress) causes alterations, at the mRNA level, of molecular machinery involved in inflammation within the colon
Date of AwardAug 2021
Original languageEnglish
Awarding Institution
  • University of Portsmouth
SupervisorJames Brown (Supervisor) & Jerome Swinny (Supervisor)

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