This commentary on my publications concerns the molecular functions of the androgen receptor (AR) and Brain Expressed X-Linked 2 (BEX2) in breast cancer. It is notable that the presented articles have made significant contributions to the fields of cancer genomics, cancer biology and experimental therapeutics with broad applications in breast cancer and other malignancies. The first chapter outlines gene expression microarray studies and explains genomic data resulting in the discovery of BEX2 in breast cancer. Chapter two elaborates on my publications regarding the molecular functions of BEX2 in promoting breast cancer cell growth and survival by modulating the mitochondrial apoptotic pathway and G1 cell cycle. In addition, this chapter explains the cross-talk between BEX2 and the NF-κB, c-Jun/JNK and ErbB2 pathways and provides a summary of my studies on the association of BEX2 expression with clinical and pathological features in breast tumors. Chapter three presents my publications on a cross-talk between AR and ErbB2-ERK signaling in estrogen receptor-negative breast cancer. Furthermore, this chapter summarizes in vitro and in vivo studies on the combined inhibition of AR and ErbB2-ERK signaling as a therapeutic strategy in molecular apocrine breast cancer. In addition, this chapter discusses the molecular functions of the Prolactin-Induced Protein, an established target gene of AR, in invasion, cell cycle and adhesion across different subtypes of breast cancer. Chapter four details my studies on the transcriptional network and novel target genes of AR in breast cancer. This chapter includes findings on AR-mediated regulation of Factor VII and the discovery of a novel protein, SRARP (C1orf64), as an AR coregulator with corepressor functions in breast cancer. In conclusion, chapter five provides a discussion on the impact of my publications in advancing different fields of cancer research and the emerging clinical applications of the presented studies in breast cancer.
|Date of Award
|Jeremy Mills (Supervisor) & Lee Banting (Supervisor)