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Dr Darren Gowers

Senior Teaching Fellow

  1. 2020
  2. Early online

    Identification and analysis of novel small molecule inhibitors of RNase E: implications for antibacterial targeting and regulation of RNase E

    Charlotte E. Mardle, Layla Goddard, Bailei Claude Spelman, Helen S. Atkins, Miss Louise Butt, Professor Paul Cox, Dr Darren Gowers, Dr Helen Vincent & Professor Anastasia Callaghan, 9 Jun 2020, In : Biochemistry and Biophysics Reports. 23, 100773.

    Research output: Contribution to journalArticle

  3. 2019
  4. Published

    A structural and biochemical comparison of Ribonuclease E homologues from pathogenic bacteria highlights species-specific properties

    Charlotte E. Mardle, Thomas Jack Shakespeare, Miss Louise Butt, Layla R. Goddard, Dr Darren Gowers, Helen S. Atkins, Dr Helen Vincent & Professor Anastasia Callaghan, 28 May 2019, In : Scientific Reports. 9, 1, 11 p., 7952.

    Research output: Contribution to journalArticle

  5. 2017
  6. Published
  7. 2013
  8. Published

    An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing

    Dr Helen Vincent, Jack Phillips, Mrs Charlotte Henderson, Adam J. Roberts, Carlanne Stone, C. Mardle, Miss Louise Butt, Dr Darren Gowers, Professor Andrew Pickford & Professor Anastasia Callaghan, 14 Nov 2013, In : PLoS One. 8, 11, p. e79142

    Research output: Contribution to journalArticle

  9. Published

    Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS

    Mrs Charlotte Henderson, Dr Helen Vincent, A. Casamento, Carlanne Stone, Jack Phillips, Peter Cary, F. Sobott, Dr Darren Gowers, James E. Taylor & Professor Anastasia Callaghan, Aug 2013, In : RNA. 19, 8, p. 1089-1104 16 p.

    Research output: Contribution to journalArticle

  10. Published

    Characterization of MicA interactions suggests a potential novel means of gene regulation by small non-coding RNAs

    Mrs Charlotte Henderson, Dr Helen Vincent, Carlanne Stone, Jack Phillips, Peter Cary, Dr Darren Gowers & Professor Anastasia Callaghan, 2013, In : Nucleic Acids Research. 41, 5, p. 3386-3397 12 p.

    Research output: Contribution to journalArticle

  11. 2012
  12. Published

    Enhanced purification and characterization of the PfeIF4A (PfH45) helicase from Plasmodium Falciparum using a codon-optimised clone

    Luke Evans, Dr Darren Gowers, Keith Firman & James Youell, Sep 2012, In : Protein Expression and Purification. 85, 1, p. 1-8 8 p.

    Research output: Contribution to journalArticle

  13. Published

    Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region

    Dr Helen Vincent, Mrs Charlotte Henderson, T. Ragan, A. Garza-Garcia, Peter Cary, Dr Darren Gowers, M. Malfois, P. Driscoll, F. Sobott & Professor Anastasia Callaghan, 29 Jun 2012, In : Journal of Molecular Biology. 420, 1-2, p. 56-69 14 p.

    Research output: Contribution to journalArticle

  14. Published

    The low-resolution solution structure of Vibrio cholerae Hfq in complex with Qrr1 sRNA

    Dr Helen Vincent, Mrs Charlotte Henderson, C. Stone, Peter Cary, Dr Darren Gowers, F. Sobott, James E. Taylor & Professor Anastasia Callaghan, 2012, In : Nucleic Acids Research. 40, 17, p. 8698-8710 13 p.

    Research output: Contribution to journalArticle

  15. 2007
  16. Published

    Restriction endonucleases that bridge and excise two recognition sites from DNA

    Jacqueline J.T. Marshall, Dr Darren Gowers & S. Halford, 2007, In : Journal of Molecular Biology. 367, 2, p. 419-431 13 p.

    Research output: Contribution to journalArticle

  17. 2005
  18. Published

    Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA

    Dr Darren Gowers, Geoffrey G. Wilson & S. Halford, 2005, In : Proceedings of the National Academy of Sciences. 102, 44, p. 15883-15888 6 p.

    Research output: Contribution to journalArticle

  19. 2004
  20. Published

    DNA restriction and modification: type II enzymes

    Dr Darren Gowers & S. Halford, 2004, Encyclopedia of biological chemistry. Lennarz, W., Lane, M., Modrich, P., Dixon, J., Carafoli, E., Exton, J. & Don, W. (eds.). Oxford: Academic Press Inc., p. 772-777 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  21. Published

    One recognition sequence, seven restriction enzymes, five reaction mechanisms

    Dr Darren Gowers, S. Bellamy & S. Halford, 2004, In : Nucleic Acids Research. 32, 11, p. 3469-3479 11 p.

    Research output: Contribution to journalArticle

  22. 2003
  23. Published

    Protein motion from non-specific to specific DNA by three-dimensional routes aided by supercoiling

    Dr Darren Gowers & S. Halford, 2003, In : EMBO Journal. 22, 6, p. 1410-1418 9 p.

    Research output: Contribution to journalArticle

  24. 2002
  25. Published

    Heterogeneity and persistence length in human ocular mucins

    A. Round, Monica Berry, T. McMaster, S. Stoll, Dr Darren Gowers, A. Corfield & M. Miles, Sep 2002, In : Biophysical Journal. 83, 3, p. 1661-1670 10 p.

    Research output: Contribution to journalArticle

  26. 2000
  27. Published

    Alternative geometries of DNA looping: an analysis using the SfiI endonuclease

    M. Watson, Dr Darren Gowers & S. Halford, 2000, In : Journal of Molecular Biology. 298, 3, p. 461-475 15 p.

    Research output: Contribution to journalArticle

  28. Published

    Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand

    K. Fox, E. Flashman & Dr Darren Gowers, 2000, In : Biochemistry. 39, 22, p. 6714-6725 12 p.

    Research output: Contribution to journalArticle

  29. Published

    Two are better than one

    S. Halford, Dr Darren Gowers & R. Sessions, 2000, In : Nature Structural Biology. 7, 9, p. 705-707 3 p.

    Research output: Contribution to journalArticle

  30. 1999
  31. Published

    DNA triple helix formation at target sites containing several pyrimidine interruptions: Stabilization by protonated cytosine or 5-(1-propargylamino)dU

    Dr Darren Gowers, Jeevan Bijapur, Tom Brown & Keith R. Fox, 24 Sep 1999, In : Biochemistry. 38, 41, p. 13747-13758 12 p.

    Research output: Contribution to journalArticle

  32. Published

    Restriction endonuclease reactions requiring two recognition sites

    S. E. Halford, D. T. Bilcock, N. P. Stanford, S. A. Williams, S. E. Milsom, N. A. Gormley, M. A. Watson, A. J. Bath, M. L. Embleton, Dr Darren Gowers & 3 others, L. E. Daniels, S. H. Parry & M. D. Szczelkun, 1 Aug 1999, In : Biochemical Society Transactions. 27, 4, p. 696-699 4 p.

    Research output: Contribution to journalArticle

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