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Dr Helen Vincent

Research Fellow

  1. 2021
  2. Accepted for publication

    Identification of novel inhibitors of Escherichia coli DNA ligase

    Arqam Mohamad Azhar Msbah Alomari, Robert Michael Nicholas Gowland, Callum Southwood, Jak Barrow, Zoe Bentley, Jashel Calvin-Nelson, Alice Kaminski, Matthew LeFevre, Professor Anastasia Callaghan, Dr Helen Vincent & 1 others, Dr Darren Gowers, 21 Apr 2021, (Accepted for publication) In: Molecules.

    Research output: Contribution to journalArticlepeer-review

  3. 2020
  4. Early online

    Identification and analysis of novel small molecule inhibitors of RNase E: implications for antibacterial targeting and regulation of RNase E

    Charlotte E. Mardle, Layla Goddard, Bailei Claude Spelman, Helen S. Atkins, Miss Louise Butt, Professor Paul Cox, Dr Darren Gowers, Dr Helen Vincent & Professor Anastasia Callaghan, 9 Jun 2020, In: Biochemistry and Biophysics Reports. 23, 100773.

    Research output: Contribution to journalArticlepeer-review

  5. 2019
  6. Published
  7. Published

    A structural and biochemical comparison of Ribonuclease E homologues from pathogenic bacteria highlights species-specific properties

    Charlotte E. Mardle, Thomas Jack Shakespeare, Miss Louise Butt, Layla R. Goddard, Dr Darren Gowers, Helen S. Atkins, Dr Helen Vincent & Professor Anastasia Callaghan, 28 May 2019, In: Scientific Reports. 9, 1, 11 p., 7952.

    Research output: Contribution to journalArticlepeer-review

  8. Early online
  9. 2018
  10. Published

    High-density functional-RNA arrays as a versatile platform for studying RNA-based interactions

    Jack Phillips, Miss Louise Butt, Mrs Charlotte Henderson, Mr Martin Adrian Devonshire, Jess Healy, Stuart J. Conway, Nicolas Locker, Professor Andrew Pickford, Dr Helen Vincent & Professor Anastasia Callaghan, 21 Aug 2018, In: Nucleic Acids Research. 46, 14, 10 p., e86.

    Research output: Contribution to journalArticlepeer-review

  11. 2017
  12. Published
  13. 2015
  14. Published

    The first small-molecule inhibitors of members of the ribonuclease E family

    Louise Kime, Dr Helen Vincent, Deena M. A. Gendoo, Stefanie S. Jourdan, Colin W. G. Fishwick, Professor Anastasia Callaghan & Kenneth J. Mcdowall, 26 Jan 2015, In: Scientific Reports. 5, 7 p., 8028.

    Research output: Contribution to journalArticlepeer-review

  15. 2013
  16. Published

    An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing

    Dr Helen Vincent, Jack Phillips, Mrs Charlotte Henderson, Adam J. Roberts, Carlanne Stone, C. Mardle, Miss Louise Butt, Dr Darren Gowers, Professor Andrew Pickford & Professor Anastasia Callaghan, 14 Nov 2013, In: PLoS One. 8, 11, p. e79142

    Research output: Contribution to journalArticlepeer-review

  17. Published

    Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS

    Mrs Charlotte Henderson, Dr Helen Vincent, A. Casamento, Carlanne Stone, Jack Phillips, Peter Cary, F. Sobott, Dr Darren Gowers, James E. Taylor & Professor Anastasia Callaghan, Aug 2013, In: RNA. 19, 8, p. 1089-1104 16 p.

    Research output: Contribution to journalArticlepeer-review

  18. Published

    Characterization of MicA interactions suggests a potential novel means of gene regulation by small non-coding RNAs

    Mrs Charlotte Henderson, Dr Helen Vincent, Carlanne Stone, Jack Phillips, Peter Cary, Dr Darren Gowers & Professor Anastasia Callaghan, 2013, In: Nucleic Acids Research. 41, 5, p. 3386-3397 12 p.

    Research output: Contribution to journalArticlepeer-review

  19. 2012
  20. Published

    Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region

    Dr Helen Vincent, Mrs Charlotte Henderson, T. Ragan, A. Garza-Garcia, Peter Cary, Dr Darren Gowers, M. Malfois, P. Driscoll, F. Sobott & Professor Anastasia Callaghan, 29 Jun 2012, In: Journal of Molecular Biology. 420, 1-2, p. 56-69 14 p.

    Research output: Contribution to journalArticlepeer-review

  21. Published

    The low-resolution solution structure of Vibrio cholerae Hfq in complex with Qrr1 sRNA

    Dr Helen Vincent, Mrs Charlotte Henderson, C. Stone, Peter Cary, Dr Darren Gowers, F. Sobott, James E. Taylor & Professor Anastasia Callaghan, 2012, In: Nucleic Acids Research. 40, 17, p. 8698-8710 13 p.

    Research output: Contribution to journalArticlepeer-review

  22. 2011
  23. Published

    Polynucleotide phosphorylase activity may be modulated by metabolites in Escherichia coli

    S. Nurmohamed, Dr Helen Vincent, C. Titman, V. Chandran, M. Pears, D. Du, J. Griffin, Professor Anastasia Callaghan & B. Luisi, Apr 2011, In: The Journal of Biological Chemistry. 286, p. 14315-14323 9 p.

    Research output: Contribution to journalArticlepeer-review

  24. 2009
  25. Published

    Insights into how RNase R degrades structured RNA: analysis of the nuclease domain

    Dr Helen Vincent & M. Deutscher, 3 Apr 2009, In: Journal of Molecular Biology. 387, 3, p. 570-583 14 p.

    Research output: Contribution to journalArticlepeer-review

  26. Published

    The roles of individual domains of RNase R in substrate binding and exoribonuclease activity. The nuclease domain is sufficient for digestion of structured RNA

    Dr Helen Vincent & M. Deutscher, 2 Jan 2009, In: The Journal of Biological Chemistry. 284, 1, p. 486-494 9 p.

    Research output: Contribution to journalArticlepeer-review

ID: 4197044