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Professor John McGeehan

Professor of Structural Biology

John McGeehan


In 1993 I graduated from the University of Glasgow with a BSc (Hons) degree in Microbiology. I went on to complete a PhD in Virology at the MRC Virology Unit, Glasgow. I worked in the Structural Biology Laboratories at the University of York before joining Professor Geoff Kneales’ group at Portsmouth University in 2000, where I worked on DNA-binding proteins. I obtained a Postdoctoral Fellowship in 2005 with the EMBL-Grenoble, France in the group of Dr Raimond Ravelli researching macromolecular crystallography and spectroscopy.

In 2007, I re-joined the University of Portsmouth taking up the appointment of RCUK Fellow and commissioned an X-ray crystallography facility. I was appointed to Reader in 2012, and Professor in 2016, taking up the Directorship of the Institute of Biological and Biomedical Sciences. I have an interest in both the structure and function of proteins, nucleic acids and their complexes. I combine X-ray crystallography with other biophysical methods such as spectroscopy, analytical ultracentrifugation and small-angle X-ray and neutron scattering.

For more information about my research please visit my lab page.

Research Interests

  • Engineering enzymes for plastic depolymerisation
  • Enzymes for biofuels and renewable chemicals
  • Structure and function of novel lignocellulose degrading proteins
  • Structural analysis of mitochondrial-encoded proteins in glioblastoma 
  • Control of restriction-modification (R-M) systems

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