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Professor John McGeehan

Professor of Structural Biology, Reader in Structural Biology

John McGeehan


In 1993 I graduated from the University of Glasgow with a BSc (Hons) degree in Microbiology. I went on to complete a PhD in Virology at the Medical Research Council Virology Unit, Glasgow. I worked in the Structural Biology Laboratories at the University of York before joining Professor Geoff Kneales’ group at Portsmouth University in 2000, where I worked for five years on DNA-binding proteins. I obtained a Postdoctoral Fellowship in 2005 with the European Molecular Biology Laboratory, Grenoble, France in the group of Dr Raimond Ravelli researching macromolecular crystallography and spectroscopy.

In 2007, I re-joined the University of Portsmouth taking up the prestigious appointment of RCUK Fellow and commissioned an X-ray crystallography facility. I was appointed to Reader of Structural Biology in 2012 and took up the Co-Directorship of the Institute of Biomedical and Biomolecular Sciences in 2016. I have an interest in both the structure and function of proteins, nucleic acids and their complexes. I combine X-ray crystallography with other biophysical methods such as spectroscopy, analytical ultracentrifugation and small-angle X-ray and neutron scattering.

For more information about my research please visit my lab page.

Research Interests

  • Structure and function of novel marine lignocellulose degrading enzymes
  • Structural analysis of mitochondrial-encoded proteins
  • Control of restriction-modification (R-M) systems
  • Nucleosome assembly proteins
  • DNA damage and therapeutic mechanisms of the anti-cancer drug Cisplatin
  • Combining crystallography and spectroscopy
  • Prion capture and gene 5 protein

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