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Professor John McGeehan

Professor of Structural Biology

  1. 2021
  2. Early online

    Engineering a cytochrome P450 for demethylation of lignin-derived aromatic aldehydes

    Emerald Ellis, Daniel James Hinchen, Alissa Bleem, Lintao Bu, Simon James Bradshaw Mallinson, Mark Devin Allen, Bennett Streit, Melodie M. Machovina, Quinlan Doolin, William E. Michener & 5 others, Christopher W. Johnson, Brandon C. Knott, Gregg T. Beckham, Professor John McGeehan & Jennifer L. DuBois, 4 Feb 2021, In: JACS Au. 10 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2020
  4. Published

    Characterization and engineering of a two-enzyme system for plastics depolymerization

    Brandon C. Knott, Erika Erickson, Mark Devin Allen, Japheth E. Gado, Rosie Graham, Fiona Kearns, Isabel Pardo, Ece Topuzlu, Jared Anderson, Harry Austin & 10 others, Graham Dominick, Christopher W. Johnson, Nicholas A. Rorrer, Caralyn Szostkiewicz, Valérie Copié, Christina Payne, H. Lee Woodcock, Bryon S. Donohoe, Gregg T. Beckham & Professor John McGeehan, 13 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 41, p. 25476-25485 10 p., 0.

    Research output: Contribution to journalArticlepeer-review

  5. 2019
  6. Published

    Enabling microbial syringol conversion through structure-guided protein engineering

    Melodie M. Machovina, Sam Mallinson, Brandon C. Knott, Alexander W. Meyers, Marc Garcia-Borràs, Lintao Bu, Japheth E. Gado, April Oliver, Graham P. Schmidt, Daniel James Hinchen & 8 others, Michael F. Crowley, Christopher W. Johnson, Ellen L. Neidle, Christina M. Payne, Kendall N. Houk, Gregg T. Beckham, Professor John McGeehan & Jennifer L. DuBois, 9 Jul 2019, In: Proceedings of the National Academy of Sciences. 116, 28, p. 13970-13976 7 p., 0.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Integrated approach reveals role of mitochondrial germ-line mutation F18L in respiratory chain, oxidative alterations, drug sensitivity, and patient prognosis in glioblastoma

    Kathleen Keatley, Samuel Stromei-Cleroux , Tammy Wiltshire, Nina Katja Maria Rajala, Gary David Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan & 6 others, Simon J. Heales, Professor Geoff Pilkington, Brigitte Meunier, Professor John McGeehan, Iain Hargreaves & Dr Rhiannon Lloyd, 9 Jul 2019, In: International Journal of Molecular Sciences. 20, 13, 3364.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease

    Ana-Caroline Raulin, Lucas Kraft, Youssra Al-Hilaly, Wei-Feng Xue, Professor John McGeehan, John Atack & L. C. Serpell, 31 May 2019, In: Journal of Molecular Biology. 431, 12, p. 2248-2265 18 p.

    Research output: Contribution to journalArticlepeer-review

  9. 2018
  10. Published

    A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion

    Sam J. B. Mallinson, Melodie M. Machovina, Rodrigo L. Silveira, Marc Garcia-Borràs, Nathan Gallup, Christopher W. Johnson, Mark D. Allen, Munir S. Skaf, Michael F. Crowley, Ellen L. Neidle & 4 others, Kendall N. Houk, Gregg T. Beckham, Jennifer L. DuBois & Professor John McGeehan, 27 Jun 2018, In: Nature Communications. 9, 1, 2487.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Characterization and engineering of a plastic-degrading aromatic polyesterase

    Harry P. Austin, Mark Devin Allen, Bryon S. Donohoe, Nicholas A. Rorrer, Rodrigo Silveira, Fiona Kearns, Benjamin Pollard, Graham Dominick, Ramona Duman, Kamel El Omari & 11 others, Vitaliy Mykhaylyk, Armin Wagner, William E. Michener, Antonella Amore, Munir S. Skaf, Michael F. Crowley, Dr Alan Thorne, H. L. Woodcock, Christopher W. Johnson, Professor John McGeehan & Gregg T. Beckham, 8 May 2018, In: Proceedings of the National Academy of Sciences. 115, 19, p. E4350-E4357 8 p.

    Research output: Contribution to journalArticlepeer-review

  12. 2017
  13. Published

    A newly identified Rab-GDI paralogue has a role in neural development in amphibia

    Liliya Nazlamova, Dr Anna Noble, Dr Frank Schubert, Professor John McGeehan, Dr Fiona Myers, Professor Matt Guille & Dr Garry Scarlett, 30 Jan 2017, In: Gene. 599, p. 78–86

    Research output: Contribution to journalArticlepeer-review

  14. 2016
  15. Published

    Radiation damage within nucleoprotein complexes studied by macromolecular X-ray crystallography

    Charles Bury, Ian Carmichael, Professor John McGeehan & Elspeth F. Garman, Nov 2016, In: Radiation Physics and Chemistry. 128, p. 118-125

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Human mitochondrial cytochrome b variants studied in yeast: not all are silent polymorphisms

    Zehua Song, Anaïs Laleve, Cindy Vallières, Professor John McGeehan, Dr Rhiannon Lloyd & Brigitte Meunier, Sep 2016, In: Human Mutation. 37, 9, p. 933-941

    Research output: Contribution to journalArticlepeer-review

  17. Published

    RNA protects a nucleoprotein complex against radiation damage

    Charles Bury, Professor John McGeehan, Alfred A. Antson, Ian Carmichael, Markus Gerstel, Mikhail B. Shevtsov & Elspeth F. Garman, May 2016, In: Acta Crystallographica Section D. D72, 5, p. 648-657

    Research output: Contribution to journalArticlepeer-review

  18. Published

    A metastable structure for the compact 30nm chromatin fibre

    Chenyi Wu, Professor John McGeehan & Andrew Travers, Apr 2016, In: FEBS Letters. 590, 7, p. 935-942 8 p.

    Research output: Contribution to journalArticlepeer-review

  19. Published

    The construction of customised nucleosomal arrays

    Chenyi Wu, Christopher Read, Professor John McGeehan & Professor Colyn Crane-Robinson, 1 Mar 2016, In: Analytical Biochemistry. 496, p. 71-75 5 p.

    Research output: Contribution to journalArticlepeer-review

  20. 2015
  21. Published

    Lignocellulose degradation mechanisms across the Tree of Life

    Professor Simon Cragg, Gregg T. Beckham, Neil C. Bruce, Tim Bugg, Daniel L. Distel, Paul Dupree, Amaia Green Etxabe, Barry S. Goodell, Jody Jellison, Professor John McGeehan & 5 others, Simon McQueen-Mason, Kirk Schnorr, Paul Howard Walton, Professor Joy Watts & Martin Zimmer, 1 Dec 2015, In: Current Opinion in Chemical Biology. 29, p. 108-119 12 p.

    Research output: Contribution to journalArticlepeer-review

  22. Published

    Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma

    Dr Rhiannon Lloyd, Kathleen Keatley, D. Timothy J. Littlewood, Bridgitte Meunier, William V. Holt, Dr Qian An, Samantha C. Higgins, Stavros Polyzoidis, Katie F. Stephenson, Keyoumars Ashkan & 3 others, Dr Helen Fillmore, Professor Geoff Pilkington & Professor John McGeehan, 1 Jul 2015, In: Neuro-Oncology. 17, 7, p. 942-952 11 p.

    Research output: Contribution to journalArticlepeer-review

  23. Published

    Radiation damage to nucleoprotein complexes in macromolecular crystallography

    Charles Bury, Elspeth F. Garman, Helen Mary Ginn, Raimond B. G. Ravelli, Ian Carmichael, Geoff Kneale & Professor John McGeehan, 1 Mar 2015, In: Journal of Synchrotron Radiation. 22, p. 213-224

    Research output: Contribution to journalArticlepeer-review

  24. Published

    Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression

    M. B. Shevtsov, S. D. Streeter, S.-J. Thresh, A. Swiderska, Professor John McGeehan & G. G. Kneale, 1 Feb 2015, In: Acta Crystallographica Section D. 71, 2, p. 398-407

    Research output: Contribution to journalArticlepeer-review

  25. 2014
  26. Published

    Structural and mutagenic analysis of the RM controller protein C.Esp1396I

    Richard N. A. Martin, Professor John McGeehan & Geoff Kneale, 2 Jun 2014, In: PLoS One. 9, 6, p. e98365 e98365.

    Research output: Contribution to journalArticlepeer-review

  27. 2013
  28. Published

    Structural analysis of DNA–protein complexes regulating the restriction–modification system Esp1396I

    Richard Martin, Professor John McGeehan, Neil J. Ball, Simon Streeter, Sarah Thresh & Geoff Kneale, Sep 2013, In: Acta Crystallographica - Section F. 69, 9, p. 1-5 5 p.

    Research output: Contribution to journalArticlepeer-review

  29. Published

    Structural analysis of mitochondrial mutations reveals a role for bigenomic protein interactions in human disease

    Dr Rhiannon Lloyd & Professor John McGeehan, Jul 2013, In: PLoS One. 8, 7, p. e69003

    Research output: Contribution to journalArticlepeer-review

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