Professor John McGeehan
Professor of Structural Biology
- 2021
- Early online
Engineering a cytochrome P450 for demethylation of lignin-derived aromatic aldehydes
Emerald Ellis, Daniel James Hinchen, Alissa Bleem, Lintao Bu, Simon James Bradshaw Mallinson, Mark Devin Allen, Bennett Streit, Melodie M. Machovina, Quinlan Doolin, William E. Michener & 5 others, , 4 Feb 2021, In: JACS Au. 10 p.Research output: Contribution to journal › Article › peer-review
- 2020
- Published
Characterization and engineering of a two-enzyme system for plastics depolymerization
Brandon C. Knott, Erika Erickson, Mark Devin Allen, Japheth E. Gado, Rosie Graham, Fiona Kearns, Isabel Pardo, Ece Topuzlu, Jared Anderson, Harry Austin & 10 others, , 13 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 41, p. 25476-25485 10 p., 0.Research output: Contribution to journal › Article › peer-review
- 2019
- Published
Enabling microbial syringol conversion through structure-guided protein engineering
Melodie M. Machovina, Sam Mallinson, Brandon C. Knott, Alexander W. Meyers, Marc Garcia-Borràs, Lintao Bu, Japheth E. Gado, April Oliver, Graham P. Schmidt, Daniel James Hinchen & 8 others, , 9 Jul 2019, In: Proceedings of the National Academy of Sciences. 116, 28, p. 13970-13976 7 p., 0.Research output: Contribution to journal › Article › peer-review
- Published
Integrated approach reveals role of mitochondrial germ-line mutation F18L in respiratory chain, oxidative alterations, drug sensitivity, and patient prognosis in glioblastoma
Kathleen Keatley, Samuel Stromei-Cleroux , Tammy Wiltshire, Nina Katja Maria Rajala, Gary David Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan & 6 others, , 9 Jul 2019, In: International Journal of Molecular Sciences. 20, 13, 3364.Research output: Contribution to journal › Article › peer-review
- Published
The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease
Ana-Caroline Raulin, Lucas Kraft, Youssra Al-Hilaly, Wei-Feng Xue, Professor John McGeehan, John Atack & L. C. Serpell, 31 May 2019, In: Journal of Molecular Biology. 431, 12, p. 2248-2265 18 p.Research output: Contribution to journal › Article › peer-review
- 2018
- Published
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
Sam J. B. Mallinson, Melodie M. Machovina, Rodrigo L. Silveira, Marc Garcia-Borràs, Nathan Gallup, Christopher W. Johnson, Mark D. Allen, Munir S. Skaf, Michael F. Crowley, Ellen L. Neidle & 4 others, , 27 Jun 2018, In: Nature Communications. 9, 1, 2487.Research output: Contribution to journal › Article › peer-review
- Published
Characterization and engineering of a plastic-degrading aromatic polyesterase
Harry P. Austin, Mark Devin Allen, Bryon S. Donohoe, Nicholas A. Rorrer, Rodrigo Silveira, Fiona Kearns, Benjamin Pollard, Graham Dominick, Ramona Duman, Kamel El Omari & 11 others, , 8 May 2018, In: Proceedings of the National Academy of Sciences. 115, 19, p. E4350-E4357 8 p.Research output: Contribution to journal › Article › peer-review
- 2017
- Published
A newly identified Rab-GDI paralogue has a role in neural development in amphibia
Liliya Nazlamova, Dr Anna Noble, Dr Frank Schubert, Professor John McGeehan, Dr Fiona Myers, Professor Matt Guille & Dr Garry Scarlett, 30 Jan 2017, In: Gene. 599, p. 78–86Research output: Contribution to journal › Article › peer-review
- 2016
- Published
Radiation damage within nucleoprotein complexes studied by macromolecular X-ray crystallography
Charles Bury, Ian Carmichael, Professor John McGeehan & Elspeth F. Garman, Nov 2016, In: Radiation Physics and Chemistry. 128, p. 118-125Research output: Contribution to journal › Article › peer-review
- Published
Human mitochondrial cytochrome b variants studied in yeast: not all are silent polymorphisms
Zehua Song, Anaïs Laleve, Cindy Vallières, Professor John McGeehan, Dr Rhiannon Lloyd & Brigitte Meunier, Sep 2016, In: Human Mutation. 37, 9, p. 933-941Research output: Contribution to journal › Article › peer-review
- Published
RNA protects a nucleoprotein complex against radiation damage
Charles Bury, Professor John McGeehan, Alfred A. Antson, Ian Carmichael, Markus Gerstel, Mikhail B. Shevtsov & Elspeth F. Garman, May 2016, In: Acta Crystallographica Section D. D72, 5, p. 648-657Research output: Contribution to journal › Article › peer-review
- Published
A metastable structure for the compact 30nm chromatin fibre
Chenyi Wu, Professor John McGeehan & Andrew Travers, Apr 2016, In: FEBS Letters. 590, 7, p. 935-942 8 p.Research output: Contribution to journal › Article › peer-review
- Published
The construction of customised nucleosomal arrays
Chenyi Wu, Christopher Read, Professor John McGeehan & Professor Colyn Crane-Robinson, 1 Mar 2016, In: Analytical Biochemistry. 496, p. 71-75 5 p.Research output: Contribution to journal › Article › peer-review
- 2015
- Published
Lignocellulose degradation mechanisms across the Tree of Life
Professor Simon Cragg, Gregg T. Beckham, Neil C. Bruce, Tim Bugg, Daniel L. Distel, Paul Dupree, Amaia Green Etxabe, Barry S. Goodell, Jody Jellison, Professor John McGeehan & 5 others, , 1 Dec 2015, In: Current Opinion in Chemical Biology. 29, p. 108-119 12 p.Research output: Contribution to journal › Article › peer-review
- Published
Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma
Dr Rhiannon Lloyd, Kathleen Keatley, D. Timothy J. Littlewood, Bridgitte Meunier, William V. Holt, Dr Qian An, Samantha C. Higgins, Stavros Polyzoidis, Katie F. Stephenson, Keyoumars Ashkan & 3 others, , 1 Jul 2015, In: Neuro-Oncology. 17, 7, p. 942-952 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Radiation damage to nucleoprotein complexes in macromolecular crystallography
Charles Bury, Elspeth F. Garman, Helen Mary Ginn, Raimond B. G. Ravelli, Ian Carmichael, Geoff Kneale & Professor John McGeehan, 1 Mar 2015, In: Journal of Synchrotron Radiation. 22, p. 213-224Research output: Contribution to journal › Article › peer-review
- Published
Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression
M. B. Shevtsov, S. D. Streeter, S.-J. Thresh, A. Swiderska, Professor John McGeehan & G. G. Kneale, 1 Feb 2015, In: Acta Crystallographica Section D. 71, 2, p. 398-407Research output: Contribution to journal › Article › peer-review
- 2014
- Published
Structural and mutagenic analysis of the RM controller protein C.Esp1396I
Richard N. A. Martin, Professor John McGeehan & Geoff Kneale, 2 Jun 2014, In: PLoS One. 9, 6, p. e98365 e98365.Research output: Contribution to journal › Article › peer-review
- 2013
- Published
Structural analysis of DNA–protein complexes regulating the restriction–modification system Esp1396I
Richard Martin, Professor John McGeehan, Neil J. Ball, Simon Streeter, Sarah Thresh & Geoff Kneale, Sep 2013, In: Acta Crystallographica - Section F. 69, 9, p. 1-5 5 p.Research output: Contribution to journal › Article › peer-review
- Published
Structural analysis of mitochondrial mutations reveals a role for bigenomic protein interactions in human disease
Dr Rhiannon Lloyd & Professor John McGeehan, Jul 2013, In: PLoS One. 8, 7, p. e69003Research output: Contribution to journal › Article › peer-review
ID: 29243