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Professor John McGeehan

Professor of Structural Biology

  1. 2021
  2. Early online

    Engineering a cytochrome P450 for demethylation of lignin-derived aromatic aldehydes

    Emerald Ellis, Daniel James Hinchen, Alissa Bleem, Lintao Bu, Simon James Bradshaw Mallinson, Mark Devin Allen, Bennett Streit, Melodie M. Machovina, Quinlan Doolin, William E. Michener & 5 others, Christopher W. Johnson, Brandon C. Knott, Gregg T. Beckham, Professor John McGeehan & Jennifer L. DuBois, 4 Feb 2021, In: JACS Au. 10 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2020
  4. Published

    Characterization and engineering of a two-enzyme system for plastics depolymerization

    Brandon C. Knott, Erika Erickson, Mark Devin Allen, Japheth E. Gado, Rosie Graham, Fiona Kearns, Isabel Pardo, Ece Topuzlu, Jared Anderson, Harry Austin & 10 others, Graham Dominick, Christopher W. Johnson, Nicholas A. Rorrer, Caralyn Szostkiewicz, Valérie Copié, Christina Payne, H. Lee Woodcock, Bryon S. Donohoe, Gregg T. Beckham & Professor John McGeehan, 13 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 41, p. 25476-25485 10 p., 0.

    Research output: Contribution to journalArticlepeer-review

  5. 2019
  6. Published

    Enabling microbial syringol conversion through structure-guided protein engineering

    Melodie M. Machovina, Sam Mallinson, Brandon C. Knott, Alexander W. Meyers, Marc Garcia-Borràs, Lintao Bu, Japheth E. Gado, April Oliver, Graham P. Schmidt, Daniel James Hinchen & 8 others, Michael F. Crowley, Christopher W. Johnson, Ellen L. Neidle, Christina M. Payne, Kendall N. Houk, Gregg T. Beckham, Professor John McGeehan & Jennifer L. DuBois, 9 Jul 2019, In: Proceedings of the National Academy of Sciences. 116, 28, p. 13970-13976 7 p., 0.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Integrated approach reveals role of mitochondrial germ-line mutation F18L in respiratory chain, oxidative alterations, drug sensitivity, and patient prognosis in glioblastoma

    Kathleen Keatley, Samuel Stromei-Cleroux , Tammy Wiltshire, Nina Katja Maria Rajala, Gary David Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan & 6 others, Simon J. Heales, Geoff Pilkington, Brigitte Meunier, Professor John McGeehan, Iain Hargreaves & Dr Rhiannon Lloyd, 9 Jul 2019, In: International Journal of Molecular Sciences. 20, 13, 3364.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease

    Ana-Caroline Raulin, Lucas Kraft, Youssra Al-Hilaly, Wei-Feng Xue, Professor John McGeehan, John Atack & L. C. Serpell, 31 May 2019, In: Journal of Molecular Biology. 431, 12, p. 2248-2265 18 p.

    Research output: Contribution to journalArticlepeer-review

  9. 2018
  10. Published

    A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion

    Sam J. B. Mallinson, Melodie M. Machovina, Rodrigo L. Silveira, Marc Garcia-Borràs, Nathan Gallup, Christopher W. Johnson, Mark D. Allen, Munir S. Skaf, Michael F. Crowley, Ellen L. Neidle & 4 others, Kendall N. Houk, Gregg T. Beckham, Jennifer L. DuBois & Professor John McGeehan, 27 Jun 2018, In: Nature Communications. 9, 1, 2487.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Characterization and engineering of a plastic-degrading aromatic polyesterase

    Harry P. Austin, Mark Devin Allen, Bryon S. Donohoe, Nicholas A. Rorrer, Rodrigo Silveira, Fiona Kearns, Benjamin Pollard, Graham Dominick, Ramona Duman, Kamel El Omari & 11 others, Vitaliy Mykhaylyk, Armin Wagner, William E. Michener, Antonella Amore, Munir S. Skaf, Michael F. Crowley, Dr Alan Thorne, H. L. Woodcock, Christopher W. Johnson, Professor John McGeehan & Gregg T. Beckham, 8 May 2018, In: Proceedings of the National Academy of Sciences. 115, 19, p. E4350-E4357 8 p.

    Research output: Contribution to journalArticlepeer-review

  12. 2017
  13. Published

    A newly identified Rab-GDI paralogue has a role in neural development in amphibia

    Liliya Nazlamova, Dr Anna Noble, Dr Frank Schubert, Professor John McGeehan, Dr Fiona Myers, Professor Matt Guille & Dr Garry Scarlett, 30 Jan 2017, In: Gene. 599, p. 78–86

    Research output: Contribution to journalArticlepeer-review

  14. 2016
  15. Published

    Radiation damage within nucleoprotein complexes studied by macromolecular X-ray crystallography

    Charles Bury, Ian Carmichael, Professor John McGeehan & Elspeth F. Garman, Nov 2016, In: Radiation Physics and Chemistry. 128, p. 118-125

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Human mitochondrial cytochrome b variants studied in yeast: not all are silent polymorphisms

    Zehua Song, Anaïs Laleve, Cindy Vallières, Professor John McGeehan, Dr Rhiannon Lloyd & Brigitte Meunier, Sep 2016, In: Human Mutation. 37, 9, p. 933-941

    Research output: Contribution to journalArticlepeer-review

  17. Published

    RNA protects a nucleoprotein complex against radiation damage

    Charles Bury, Professor John McGeehan, Alfred A. Antson, Ian Carmichael, Markus Gerstel, Mikhail B. Shevtsov & Elspeth F. Garman, May 2016, In: Acta Crystallographica Section D. D72, 5, p. 648-657

    Research output: Contribution to journalArticlepeer-review

  18. Published

    A metastable structure for the compact 30nm chromatin fibre

    Chenyi Wu, Professor John McGeehan & Andrew Travers, Apr 2016, In: FEBS Letters. 590, 7, p. 935-942 8 p.

    Research output: Contribution to journalArticlepeer-review

  19. Published

    The construction of customised nucleosomal arrays

    Chenyi Wu, Christopher Read, Professor John McGeehan & Colyn Crane-robinson, 1 Mar 2016, In: Analytical Biochemistry. 496, p. 71-75 5 p.

    Research output: Contribution to journalArticlepeer-review

  20. 2015
  21. Published

    Lignocellulose degradation mechanisms across the Tree of Life

    Professor Simon Cragg, Gregg T. Beckham, Neil C. Bruce, Tim Bugg, Daniel L. Distel, Paul Dupree, Amaia Green Etxabe, Barry S. Goodell, Jody Jellison, Professor John McGeehan & 5 others, Simon McQueen-Mason, Kirk Schnorr, Paul Howard Walton, Professor Joy Watts & Martin Zimmer, 1 Dec 2015, In: Current Opinion in Chemical Biology. 29, p. 108-119 12 p.

    Research output: Contribution to journalArticlepeer-review

  22. Published

    Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma

    Dr Rhiannon Lloyd, Kathleen Keatley, D. Timothy J. Littlewood, Bridgitte Meunier, William V. Holt, Dr Qian An, Samantha C. Higgins, Stavros Polyzoidis, Katie F. Stephenson, Keyoumars Ashkan & 3 others, Dr Helen Fillmore, Geoff J. Pilkington & Professor John McGeehan, 1 Jul 2015, In: Neuro-Oncology. 17, 7, p. 942-952 11 p.

    Research output: Contribution to journalArticlepeer-review

  23. Published

    Radiation damage to nucleoprotein complexes in macromolecular crystallography

    Charles Bury, Elspeth F. Garman, Helen Mary Ginn, Raimond B. G. Ravelli, Ian Carmichael, Geoff Kneale & Professor John McGeehan, 1 Mar 2015, In: Journal of Synchrotron Radiation. 22, p. 213-224

    Research output: Contribution to journalArticlepeer-review

  24. Published

    Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression

    M. B. Shevtsov, S. D. Streeter, S.-J. Thresh, A. Swiderska, Professor John McGeehan & G. G. Kneale, 1 Feb 2015, In: Acta Crystallographica Section D. 71, 2, p. 398-407

    Research output: Contribution to journalArticlepeer-review

  25. 2014
  26. Published

    Structural and mutagenic analysis of the RM controller protein C.Esp1396I

    Richard N. A. Martin, Professor John McGeehan & Geoff Kneale, 2 Jun 2014, In: PLoS One. 9, 6, p. e98365 e98365.

    Research output: Contribution to journalArticlepeer-review

  27. 2013
  28. Published

    Structural analysis of DNA–protein complexes regulating the restriction–modification system Esp1396I

    Richard Martin, Professor John McGeehan, Neil J. Ball, Simon Streeter, Sarah Thresh & Geoff Kneale, Sep 2013, In: Acta Crystallographica - Section F. 69, 9, p. 1-5 5 p.

    Research output: Contribution to journalArticlepeer-review

  29. Published

    Structural analysis of mitochondrial mutations reveals a role for bigenomic protein interactions in human disease

    Dr Rhiannon Lloyd & Professor John McGeehan, Jul 2013, In: PLoS One. 8, 7, p. e69003

    Research output: Contribution to journalArticlepeer-review

  30. Published

    Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance

    M. Kern, Professor John McGeehan, Simon Streeter, Richard Martin, K. Besser, L. Elias, W. Eborall, Dr Graham Paul Malyon, C. Payne, M. Himmel & 5 others, K. Schnorr, G. Beckham, Professor Simon Cragg, N. Bruce & S. McQueen-Mason, 18 Jun 2013, In: Proceedings of the National Academy of Sciences. 110, 25, p. 10189-10194 6 p.

    Research output: Contribution to journalArticlepeer-review

  31. Published

    Non-rigid image registration to reduce beam-induced blurring of cryo-electron microscopy images

    F. Karimi Nejadasl, M. Karuppasamy, E. Newman, Professor John McGeehan & R. Ravelli, 1 Jan 2013, In: Journal of Synchrotron Radiation. 20, 1

    Research output: Contribution to journalArticlepeer-review

  32. 2012
  33. Published

    Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex

    Professor John McGeehan, Neil J. Ball, Simon Streeter, Sarah Thresh & Geoff Kneale, 30 Dec 2012, In: Nucleic Acids Research. 40, 9, p. 4158-4167 10 p.

    Research output: Contribution to journalArticlepeer-review

  34. Published

    Large multimeric assemblies of nucleosome assembly protein and histones revealed by small-angle X-ray scattering and electron microscopy

    E. Newman, Geoff Kneale, R. Ravelli, M. Karuppasamy, F. Nejadasl, I. Taylor & Professor John McGeehan, 2012, In: The Journal of Biological Chemistry. 287, 32, p. 26657-26665 9 p.

    Research output: Contribution to journalArticlepeer-review

  35. Published

    The structural basis of differential DNA sequence recognition by restriction–modification controller proteins

    Neil J. Ball, Professor John McGeehan, Simon Streeter, Sarah Thresh & Geoff Kneale, 2012, In: Nucleic Acids Research. 40, 20, p. 10532-10542 11 p.

    Research output: Contribution to journalArticlepeer-review

  36. 2011
  37. Published

    Amyloid- 42 interacts mainly with insoluble prion protein in the Alzheimer brain

    Wen-Quan Zou, Xiangzhu Xiao, Jue Yuan, Gianfranco Puoti, Hisashi Fujioka, Xinglong Wang, Sandy Richardson, Xiaochen Zhou, Roger Zou, Shihao Li & 10 others, Xiongwei Zhu, Patrick L. McGeer, Professor John McGeehan, Geoff Kneale, Diego E. Rincon-Limas, Pedro Fernandez-Funez, Hyoung-Gon Lee, Mark A. Smith, Robert B. Petersen & Jian-Ping Guo, 29 Apr 2011, In: The Journal of Biological Chemistry. 286, 17, p. 15095-15105

    Research output: Contribution to journalArticlepeer-review

  38. Published

    Infrared protein crystallography

    J. Timothy Sage, Yunbin Zhang, Professor John McGeehan, Raimond B. G. Ravelli, Martin Weik & Jasper J. Van Thor, 2011, In: Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 1814, 6, p. 760-777 18 p.

    Research output: Contribution to journalArticlepeer-review

  39. Published

    Size does matter: sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action

    John Spencer, Jahangir Amin, Dr Peter Coxhead, Professor John McGeehan, Christopher J. Richards, Graham J. Tizzard, Simon J. Coles, John P. Bingham, John A. Hartley, Li Feng & 2 others, Eric Meggers & Professor Matt Guille, 2011, In: Organometallics. 30, 11, p. 3177-3181

    Research output: Contribution to journalArticlepeer-review

  40. Published

    Structural analysis of a novel class of R-M controller proteins: C.Csp231I from Citrobacter sp. RFL231

    Professor John McGeehan, Simon Streeter, Sarah Thresh, J. Taylor, Misha Shevtsov & Geoff Kneale, 2011, In: Journal of Molecular Biology. 409, 2, p. 177-188 12 p.

    Research output: Contribution to journalArticlepeer-review

  41. 2010
  42. Published

    Reply to Kascsak: definition of the PrP 3F4 epitope revisited

    W. Zou, J. Langeveld, X. Xiao, S. Chen, P. McGeer, J. Yuan, M. Payne, H. Kang, Professor John McGeehan, M. Sy & 10 others, N. Greenspan, D. Kaplan, G. Wang, P. Parchi, E. Hoover, Geoff Kneale, G. Telling, W. Surewicz, Q. Kong & J. Guo, 14 May 2010, In: The Journal of Biological Chemistry. 285, 20, p. le6-le6

    Research output: Contribution to journalArticle

  43. Published

    PrP conformational transitions alter species preference of a PrP-specific antibody

    Wen-Quan Zou, Jan Langeveld, Xiangzhu Xiao, Shugui Chen, P. L. Mcgeer, Jue Yuan, Michael C. Payne, Hae-Eun Kang, Professor John McGeehan, Man-Sun Sy & 10 others, Neil S. Greenspan, David Kaplan, Gong-Xian Wang, Piero Parchi, Edward Hoover, Geoff Kneale, Glenn Telling, Witold K. Surewicz, Qingzhong Kong & Jian-Ping Guo, 30 Apr 2010, In: The Journal of Biological Chemistry. 285, 18, p. 13874-13884

    Research output: Contribution to journalArticlepeer-review

  44. Published

    New insights from NMR, FTIR, X-ray diffraction and physical chemistry into digestive processes in the wood-boring marine crustacean Limnoria quadripunctata

    Dr Graham Paul Malyon, S. LaBarre, N. Kervarec, Peter Cary, Professor John McGeehan, X. Xie, A. Kluppel & Professor Simon Cragg, 2010, p. 1-16. 16 p.

    Research output: Contribution to conferencePaperpeer-review

  45. Published

    Raman-assisted crystallography of biomolecules at the synchrotron: Instrumentation, methods and applications

    Professor John McGeehan, D. Bourgeois, A. Royant & P. Carpentier, 2010, In: Biochimica et Biophysica Acta. 1814, 6, p. 750-759 10 p.

    Research output: Contribution to journalArticlepeer-review

  46. 2009
  47. Published

    Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease

    Xiangzhu Xiao, Leticia Miravalle, Jue Yuan, Professor John McGeehan, Zhigian Dong, Robert Wyza, Gregory T. MacLennan, Alan M. Golichowski, Geoff Kneale, Nicholas King & 7 others, Qingzhong Kong, Salvatore Spina, Ruben Vidal, Bernardino Ghetti, Karen Roos, Pierluigi Gambetti & Wen-Quan Zou, May 2009, In: American Journal of Pathology. 174, 5, p. 1602-1608

    Research output: Contribution to journalArticlepeer-review

  48. Published

    Colouring cryo-cooled crystals: on-line microspectrophotometry

    Professor John McGeehan, R. Ravelli, J. W. Murray, Robin Leslie Owen, F. Cipriani, S. McSweeney, M. Weik & E. Garman, 2009, In: Journal of Synchrotron Radiation. 16, p. 163-172 10 p.

    Research output: Contribution to journalArticlepeer-review

  49. Published

    Overexpression, purification and preliminary X-ray diffraction analysis of the controller protein C.Csp231I from Citrobacter sp. RFL231

    Simon Streeter, Professor John McGeehan & Geoff Kneale, 2009, In: Acta Crystallographica - Section F. F65, Pt 9, p. 898-901 4 p.

    Research output: Contribution to journalArticlepeer-review

  50. Published

    Structural and biophysical characterization of the proteins interacting with the herpes simplex virus-1 origin of replication

    I. Manolaridis, E. Mumtsidu, P. Konarev, A. Makhov, S. Fullerton, A. Sinz, S. Kalkhof, Professor John McGeehan, Peter Cary, J. Griffith & 3 others, D. Svergun, Geoff Kneale & P. Tucker, 2009, In: The Journal of Biological Chemistry. 284, 24, p. 16343-16353 11 p.

    Research output: Contribution to journalArticlepeer-review

  51. Published

    Structure of the restriction-modification controller protein C.Esp1396I

    Neil J. Ball, Simon Streeter, Geoff Kneale & Professor John McGeehan, 2009, In: Acta Crystallographica Section D Biological Crystallography. D65, p. 900-905 6 p.

    Research output: Contribution to journalArticlepeer-review

  52. Published

    X-ray tomography on MX samples

    S. Brockhauser, A. McCarthy, M. Di Michiel & Professor John McGeehan, 2009, p. S166.

    Research output: Contribution to conferencePaperpeer-review

  53. 2008
  54. Published

    Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions

    J. Yuan, Z. Dong, J. Guo, Professor John McGeehan, X. Xiao, J. Wang, I. Cali, P. McGeer, N. Cashman, R. Bessen & 5 others, W. Surewicz, Geoff Kneale, R. Petersen, P. Gambetti & Wen-Quan Zou, 2008, In: Cellular and Molecular Life Sciences (CMLS). 65, 4, p. 631-643 13 p.

    Research output: Contribution to journalArticlepeer-review

  55. Published

    Structural analysis of the genetic switch that regulates the expression of restriction-modification genes

    Professor John McGeehan, Simon Streeter, Sarah Thresh, Neil J. Ball, R. Ravelli & Geoff Kneale, 2008, In: Nucleic Acids Research. 36, 14, p. 4778-4787 10 p.

    Research output: Contribution to journalArticlepeer-review

  56. Published

    X-ray tomographic reconstruction of macromolecular samples

    S. Brockhauser, M. Di Michiel, Professor John McGeehan, A. McCarthy & R. Ravelli, 2008, In: Journal of Applied Crystallography. 41, p. 1057-1066 10 p.

    Research output: Contribution to journalArticlepeer-review

  57. 2007
  58. Published

    Advances in spectroscopic methods for biological crystals. 1. Fluorescence lifetime measurements

    A. Royant, P. Carpentier, J. Ohana, Professor John McGeehan, B. Paetzold, M. Noirclerc-Savoye, X. Verne, V. Adam & D. Bourgeois, 2007, In: Journal of Applied Crystallography. 40, 6, p. 1105-1112 8 p.

    Research output: Contribution to journalArticlepeer-review

  59. Published

    Plastic-embedded protein crystals

    R. Ravelli, U. Haselmann-Weiss, Professor John McGeehan, A. McCarthy, J. Marquez, C. Antony, A. Frangakis & G. Stranzl, 2007, In: Journal of Synchrotron Radiation. 14, 1, p. 128-132 5 p.

    Research output: Contribution to journalArticlepeer-review

  60. Published

    X-ray radiation-induced damage in DNA monitored by online Raman

    Professor John McGeehan, P. Carpentier, A. Royant, D. Bourgeois & R. Ravelli, 2007, In: Journal of Synchrotron Radiation. 14, 1, p. 99-108 10 p.

    Research output: Contribution to journalArticlepeer-review

  61. 2006
  62. Published

    Cooperative binding of the C.AhdI controller protein to the C/R promoter and its role in endonuclease gene expression

    Professor John McGeehan, I. Papapanagiotou, Simon Streeter & Geoff Kneale, 2006, In: Journal of Molecular Biology. 358, 2, p. 523-531 9 p.

    Research output: Contribution to journalArticlepeer-review

  63. Published

    Identification of a structural and functional domain in xNAP1 involved in protein–protein interactions

    C. Friedeberg, Dr Garry Scarlett, Professor John McGeehan, Dr Anita Abu Daya, Professor Matt Guille & Geoff Kneale, 2006, In: Nucleic Acids Research. 34, 17, p. 4893-4899 7 p.

    Research output: Contribution to journalArticlepeer-review

  64. Published

    Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains

    J. Yuan, X. Xiao, Professor John McGeehan, Z. Dong, I. Cali, H. Fujioka, Q. Kong, Geoff Kneale, P. Gambetti & W. Zou, 2006, In: The Journal of Biological Chemistry. 281, 46, p. 34848-34858 11 p.

    Research output: Contribution to journalArticlepeer-review

  65. 2005
  66. Published

    Cloning, expression, purification, and characterisation of the dUTPase encoded by the integrated Bacillus subtilis temperate bacteriophage SPβ

    R. Persson, Professor John McGeehan & K. Wilson, 2005, In: Protein Expression and Purification. 42, 1, p. 92-99 8 p.

    Research output: Contribution to journalArticlepeer-review

  67. Published

    Concealment of epitope by reduction and alkylation in prion protein

    J. Yuan, M. Kinter, Professor John McGeehan, G. Perry, Geoff Kneale, P. Gambetti & W-Z. Zou, 2005, In: Biochemical and Biophysical Research Communications. 326, 3, p. 652-659 8 p.

    Research output: Contribution to journalArticlepeer-review

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