Professor John McGeehan
Professor of Structural Biology
- 2021
- Early online
Engineering a cytochrome P450 for demethylation of lignin-derived aromatic aldehydes
Emerald Ellis, Daniel James Hinchen, Alissa Bleem, Lintao Bu, Simon James Bradshaw Mallinson, Mark Devin Allen, Bennett Streit, Melodie M. Machovina, Quinlan Doolin, William E. Michener & 5 others, , 4 Feb 2021, In: JACS Au. 10 p.Research output: Contribution to journal › Article › peer-review
- 2020
- Published
Characterization and engineering of a two-enzyme system for plastics depolymerization
Brandon C. Knott, Erika Erickson, Mark Devin Allen, Japheth E. Gado, Rosie Graham, Fiona Kearns, Isabel Pardo, Ece Topuzlu, Jared Anderson, Harry Austin & 10 others, , 13 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 41, p. 25476-25485 10 p., 0.Research output: Contribution to journal › Article › peer-review
- 2019
- Published
Enabling microbial syringol conversion through structure-guided protein engineering
Melodie M. Machovina, Sam Mallinson, Brandon C. Knott, Alexander W. Meyers, Marc Garcia-Borràs, Lintao Bu, Japheth E. Gado, April Oliver, Graham P. Schmidt, Daniel James Hinchen & 8 others, , 9 Jul 2019, In: Proceedings of the National Academy of Sciences. 116, 28, p. 13970-13976 7 p., 0.Research output: Contribution to journal › Article › peer-review
- Published
Integrated approach reveals role of mitochondrial germ-line mutation F18L in respiratory chain, oxidative alterations, drug sensitivity, and patient prognosis in glioblastoma
Kathleen Keatley, Samuel Stromei-Cleroux , Tammy Wiltshire, Nina Katja Maria Rajala, Gary David Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan & 6 others, , 9 Jul 2019, In: International Journal of Molecular Sciences. 20, 13, 3364.Research output: Contribution to journal › Article › peer-review
- Published
The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease
Ana-Caroline Raulin, Lucas Kraft, Youssra Al-Hilaly, Wei-Feng Xue, Professor John McGeehan, John Atack & L. C. Serpell, 31 May 2019, In: Journal of Molecular Biology. 431, 12, p. 2248-2265 18 p.Research output: Contribution to journal › Article › peer-review
- 2018
- Published
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
Sam J. B. Mallinson, Melodie M. Machovina, Rodrigo L. Silveira, Marc Garcia-Borràs, Nathan Gallup, Christopher W. Johnson, Mark D. Allen, Munir S. Skaf, Michael F. Crowley, Ellen L. Neidle & 4 others, , 27 Jun 2018, In: Nature Communications. 9, 1, 2487.Research output: Contribution to journal › Article › peer-review
- Published
Characterization and engineering of a plastic-degrading aromatic polyesterase
Harry P. Austin, Mark Devin Allen, Bryon S. Donohoe, Nicholas A. Rorrer, Rodrigo Silveira, Fiona Kearns, Benjamin Pollard, Graham Dominick, Ramona Duman, Kamel El Omari & 11 others, , 8 May 2018, In: Proceedings of the National Academy of Sciences. 115, 19, p. E4350-E4357 8 p.Research output: Contribution to journal › Article › peer-review
- 2017
- Published
A newly identified Rab-GDI paralogue has a role in neural development in amphibia
Liliya Nazlamova, Dr Anna Noble, Dr Frank Schubert, Professor John McGeehan, Dr Fiona Myers, Professor Matt Guille & Dr Garry Scarlett, 30 Jan 2017, In: Gene. 599, p. 78–86Research output: Contribution to journal › Article › peer-review
- 2016
- Published
Radiation damage within nucleoprotein complexes studied by macromolecular X-ray crystallography
Charles Bury, Ian Carmichael, Professor John McGeehan & Elspeth F. Garman, Nov 2016, In: Radiation Physics and Chemistry. 128, p. 118-125Research output: Contribution to journal › Article › peer-review
- Published
Human mitochondrial cytochrome b variants studied in yeast: not all are silent polymorphisms
Zehua Song, Anaïs Laleve, Cindy Vallières, Professor John McGeehan, Dr Rhiannon Lloyd & Brigitte Meunier, Sep 2016, In: Human Mutation. 37, 9, p. 933-941Research output: Contribution to journal › Article › peer-review
- Published
RNA protects a nucleoprotein complex against radiation damage
Charles Bury, Professor John McGeehan, Alfred A. Antson, Ian Carmichael, Markus Gerstel, Mikhail B. Shevtsov & Elspeth F. Garman, May 2016, In: Acta Crystallographica Section D. D72, 5, p. 648-657Research output: Contribution to journal › Article › peer-review
- Published
A metastable structure for the compact 30nm chromatin fibre
Chenyi Wu, Professor John McGeehan & Andrew Travers, Apr 2016, In: FEBS Letters. 590, 7, p. 935-942 8 p.Research output: Contribution to journal › Article › peer-review
- Published
The construction of customised nucleosomal arrays
Chenyi Wu, Christopher Read, Professor John McGeehan & Colyn Crane-robinson, 1 Mar 2016, In: Analytical Biochemistry. 496, p. 71-75 5 p.Research output: Contribution to journal › Article › peer-review
- 2015
- Published
Lignocellulose degradation mechanisms across the Tree of Life
Professor Simon Cragg, Gregg T. Beckham, Neil C. Bruce, Tim Bugg, Daniel L. Distel, Paul Dupree, Amaia Green Etxabe, Barry S. Goodell, Jody Jellison, Professor John McGeehan & 5 others, , 1 Dec 2015, In: Current Opinion in Chemical Biology. 29, p. 108-119 12 p.Research output: Contribution to journal › Article › peer-review
- Published
Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma
Dr Rhiannon Lloyd, Kathleen Keatley, D. Timothy J. Littlewood, Bridgitte Meunier, William V. Holt, Dr Qian An, Samantha C. Higgins, Stavros Polyzoidis, Katie F. Stephenson, Keyoumars Ashkan & 3 others, , 1 Jul 2015, In: Neuro-Oncology. 17, 7, p. 942-952 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Radiation damage to nucleoprotein complexes in macromolecular crystallography
Charles Bury, Elspeth F. Garman, Helen Mary Ginn, Raimond B. G. Ravelli, Ian Carmichael, Geoff Kneale & Professor John McGeehan, 1 Mar 2015, In: Journal of Synchrotron Radiation. 22, p. 213-224Research output: Contribution to journal › Article › peer-review
- Published
Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression
M. B. Shevtsov, S. D. Streeter, S.-J. Thresh, A. Swiderska, Professor John McGeehan & G. G. Kneale, 1 Feb 2015, In: Acta Crystallographica Section D. 71, 2, p. 398-407Research output: Contribution to journal › Article › peer-review
- 2014
- Published
Structural and mutagenic analysis of the RM controller protein C.Esp1396I
Richard N. A. Martin, Professor John McGeehan & Geoff Kneale, 2 Jun 2014, In: PLoS One. 9, 6, p. e98365 e98365.Research output: Contribution to journal › Article › peer-review
- 2013
- Published
Structural analysis of DNA–protein complexes regulating the restriction–modification system Esp1396I
Richard Martin, Professor John McGeehan, Neil J. Ball, Simon Streeter, Sarah Thresh & Geoff Kneale, Sep 2013, In: Acta Crystallographica - Section F. 69, 9, p. 1-5 5 p.Research output: Contribution to journal › Article › peer-review
- Published
Structural analysis of mitochondrial mutations reveals a role for bigenomic protein interactions in human disease
Dr Rhiannon Lloyd & Professor John McGeehan, Jul 2013, In: PLoS One. 8, 7, p. e69003Research output: Contribution to journal › Article › peer-review
- Published
Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance
M. Kern, Professor John McGeehan, Simon Streeter, Richard Martin, K. Besser, L. Elias, W. Eborall, Dr Graham Paul Malyon, C. Payne, M. Himmel & 5 others, , 18 Jun 2013, In: Proceedings of the National Academy of Sciences. 110, 25, p. 10189-10194 6 p.Research output: Contribution to journal › Article › peer-review
- Published
Non-rigid image registration to reduce beam-induced blurring of cryo-electron microscopy images
F. Karimi Nejadasl, M. Karuppasamy, E. Newman, Professor John McGeehan & R. Ravelli, 1 Jan 2013, In: Journal of Synchrotron Radiation. 20, 1Research output: Contribution to journal › Article › peer-review
- 2012
- Published
Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex
Professor John McGeehan, Neil J. Ball, Simon Streeter, Sarah Thresh & Geoff Kneale, 30 Dec 2012, In: Nucleic Acids Research. 40, 9, p. 4158-4167 10 p.Research output: Contribution to journal › Article › peer-review
- Published
Large multimeric assemblies of nucleosome assembly protein and histones revealed by small-angle X-ray scattering and electron microscopy
E. Newman, Geoff Kneale, R. Ravelli, M. Karuppasamy, F. Nejadasl, I. Taylor & Professor John McGeehan, 2012, In: The Journal of Biological Chemistry. 287, 32, p. 26657-26665 9 p.Research output: Contribution to journal › Article › peer-review
- Published
The structural basis of differential DNA sequence recognition by restriction–modification controller proteins
Neil J. Ball, Professor John McGeehan, Simon Streeter, Sarah Thresh & Geoff Kneale, 2012, In: Nucleic Acids Research. 40, 20, p. 10532-10542 11 p.Research output: Contribution to journal › Article › peer-review
- 2011
- Published
Amyloid- 42 interacts mainly with insoluble prion protein in the Alzheimer brain
Wen-Quan Zou, Xiangzhu Xiao, Jue Yuan, Gianfranco Puoti, Hisashi Fujioka, Xinglong Wang, Sandy Richardson, Xiaochen Zhou, Roger Zou, Shihao Li & 10 others, , 29 Apr 2011, In: The Journal of Biological Chemistry. 286, 17, p. 15095-15105Research output: Contribution to journal › Article › peer-review
- Published
Infrared protein crystallography
J. Timothy Sage, Yunbin Zhang, Professor John McGeehan, Raimond B. G. Ravelli, Martin Weik & Jasper J. Van Thor, 2011, In: Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 1814, 6, p. 760-777 18 p.Research output: Contribution to journal › Article › peer-review
- Published
Size does matter: sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action
John Spencer, Jahangir Amin, Dr Peter Coxhead, Professor John McGeehan, Christopher J. Richards, Graham J. Tizzard, Simon J. Coles, John P. Bingham, John A. Hartley, Li Feng & 2 others, , 2011, In: Organometallics. 30, 11, p. 3177-3181Research output: Contribution to journal › Article › peer-review
- Published
Structural analysis of a novel class of R-M controller proteins: C.Csp231I from Citrobacter sp. RFL231
Professor John McGeehan, Simon Streeter, Sarah Thresh, J. Taylor, Misha Shevtsov & Geoff Kneale, 2011, In: Journal of Molecular Biology. 409, 2, p. 177-188 12 p.Research output: Contribution to journal › Article › peer-review
- 2010
- Published
Reply to Kascsak: definition of the PrP 3F4 epitope revisited
W. Zou, J. Langeveld, X. Xiao, S. Chen, P. McGeer, J. Yuan, M. Payne, H. Kang, Professor John McGeehan, M. Sy & 10 others, , 14 May 2010, In: The Journal of Biological Chemistry. 285, 20, p. le6-le6Research output: Contribution to journal › Article
- Published
PrP conformational transitions alter species preference of a PrP-specific antibody
Wen-Quan Zou, Jan Langeveld, Xiangzhu Xiao, Shugui Chen, P. L. Mcgeer, Jue Yuan, Michael C. Payne, Hae-Eun Kang, Professor John McGeehan, Man-Sun Sy & 10 others, , 30 Apr 2010, In: The Journal of Biological Chemistry. 285, 18, p. 13874-13884Research output: Contribution to journal › Article › peer-review
- Published
New insights from NMR, FTIR, X-ray diffraction and physical chemistry into digestive processes in the wood-boring marine crustacean Limnoria quadripunctata
Dr Graham Paul Malyon, S. LaBarre, N. Kervarec, Peter Cary, Professor John McGeehan, X. Xie, A. Kluppel & Professor Simon Cragg, 2010, p. 1-16. 16 p.Research output: Contribution to conference › Paper › peer-review
- Published
Raman-assisted crystallography of biomolecules at the synchrotron: Instrumentation, methods and applications
Professor John McGeehan, D. Bourgeois, A. Royant & P. Carpentier, 2010, In: Biochimica et Biophysica Acta. 1814, 6, p. 750-759 10 p.Research output: Contribution to journal › Article › peer-review
- 2009
- Published
Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease
Xiangzhu Xiao, Leticia Miravalle, Jue Yuan, Professor John McGeehan, Zhigian Dong, Robert Wyza, Gregory T. MacLennan, Alan M. Golichowski, Geoff Kneale, Nicholas King & 7 others, , May 2009, In: American Journal of Pathology. 174, 5, p. 1602-1608Research output: Contribution to journal › Article › peer-review
- Published
Colouring cryo-cooled crystals: on-line microspectrophotometry
Professor John McGeehan, R. Ravelli, J. W. Murray, Robin Leslie Owen, F. Cipriani, S. McSweeney, M. Weik & E. Garman, 2009, In: Journal of Synchrotron Radiation. 16, p. 163-172 10 p.Research output: Contribution to journal › Article › peer-review
- Published
Overexpression, purification and preliminary X-ray diffraction analysis of the controller protein C.Csp231I from Citrobacter sp. RFL231
Simon Streeter, Professor John McGeehan & Geoff Kneale, 2009, In: Acta Crystallographica - Section F. F65, Pt 9, p. 898-901 4 p.Research output: Contribution to journal › Article › peer-review
- Published
Structural and biophysical characterization of the proteins interacting with the herpes simplex virus-1 origin of replication
I. Manolaridis, E. Mumtsidu, P. Konarev, A. Makhov, S. Fullerton, A. Sinz, S. Kalkhof, Professor John McGeehan, Peter Cary, J. Griffith & 3 others, , 2009, In: The Journal of Biological Chemistry. 284, 24, p. 16343-16353 11 p.Research output: Contribution to journal › Article › peer-review
- Published
Structure of the restriction-modification controller protein C.Esp1396I
Neil J. Ball, Simon Streeter, Geoff Kneale & Professor John McGeehan, 2009, In: Acta Crystallographica Section D Biological Crystallography. D65, p. 900-905 6 p.Research output: Contribution to journal › Article › peer-review
- Published
X-ray tomography on MX samples
S. Brockhauser, A. McCarthy, M. Di Michiel & Professor John McGeehan, 2009, p. S166.Research output: Contribution to conference › Paper › peer-review
- 2008
- Published
Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions
J. Yuan, Z. Dong, J. Guo, Professor John McGeehan, X. Xiao, J. Wang, I. Cali, P. McGeer, N. Cashman, R. Bessen & 5 others, , 2008, In: Cellular and Molecular Life Sciences (CMLS). 65, 4, p. 631-643 13 p.Research output: Contribution to journal › Article › peer-review
- Published
Structural analysis of the genetic switch that regulates the expression of restriction-modification genes
Professor John McGeehan, Simon Streeter, Sarah Thresh, Neil J. Ball, R. Ravelli & Geoff Kneale, 2008, In: Nucleic Acids Research. 36, 14, p. 4778-4787 10 p.Research output: Contribution to journal › Article › peer-review
- Published
X-ray tomographic reconstruction of macromolecular samples
S. Brockhauser, M. Di Michiel, Professor John McGeehan, A. McCarthy & R. Ravelli, 2008, In: Journal of Applied Crystallography. 41, p. 1057-1066 10 p.Research output: Contribution to journal › Article › peer-review
- 2007
- Published
Advances in spectroscopic methods for biological crystals. 1. Fluorescence lifetime measurements
A. Royant, P. Carpentier, J. Ohana, Professor John McGeehan, B. Paetzold, M. Noirclerc-Savoye, X. Verne, V. Adam & D. Bourgeois, 2007, In: Journal of Applied Crystallography. 40, 6, p. 1105-1112 8 p.Research output: Contribution to journal › Article › peer-review
- Published
Plastic-embedded protein crystals
R. Ravelli, U. Haselmann-Weiss, Professor John McGeehan, A. McCarthy, J. Marquez, C. Antony, A. Frangakis & G. Stranzl, 2007, In: Journal of Synchrotron Radiation. 14, 1, p. 128-132 5 p.Research output: Contribution to journal › Article › peer-review
- Published
X-ray radiation-induced damage in DNA monitored by online Raman
Professor John McGeehan, P. Carpentier, A. Royant, D. Bourgeois & R. Ravelli, 2007, In: Journal of Synchrotron Radiation. 14, 1, p. 99-108 10 p.Research output: Contribution to journal › Article › peer-review
- 2006
- Published
Cooperative binding of the C.AhdI controller protein to the C/R promoter and its role in endonuclease gene expression
Professor John McGeehan, I. Papapanagiotou, Simon Streeter & Geoff Kneale, 2006, In: Journal of Molecular Biology. 358, 2, p. 523-531 9 p.Research output: Contribution to journal › Article › peer-review
- Published
Identification of a structural and functional domain in xNAP1 involved in protein–protein interactions
C. Friedeberg, Dr Garry Scarlett, Professor John McGeehan, Dr Anita Abu Daya, Professor Matt Guille & Geoff Kneale, 2006, In: Nucleic Acids Research. 34, 17, p. 4893-4899 7 p.Research output: Contribution to journal › Article › peer-review
- Published
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains
J. Yuan, X. Xiao, Professor John McGeehan, Z. Dong, I. Cali, H. Fujioka, Q. Kong, Geoff Kneale, P. Gambetti & W. Zou, 2006, In: The Journal of Biological Chemistry. 281, 46, p. 34848-34858 11 p.Research output: Contribution to journal › Article › peer-review
- 2005
- Published
Cloning, expression, purification, and characterisation of the dUTPase encoded by the integrated Bacillus subtilis temperate bacteriophage SPβ
R. Persson, Professor John McGeehan & K. Wilson, 2005, In: Protein Expression and Purification. 42, 1, p. 92-99 8 p.Research output: Contribution to journal › Article › peer-review
- Published
Concealment of epitope by reduction and alkylation in prion protein
J. Yuan, M. Kinter, Professor John McGeehan, G. Perry, Geoff Kneale, P. Gambetti & W-Z. Zou, 2005, In: Biochemical and Biophysical Research Communications. 326, 3, p. 652-659 8 p.Research output: Contribution to journal › Article › peer-review
- Published
High-resolution crystal structure of the restriction–modification controller protein C.AhdI from Aeromonas hydrophila
Professor John McGeehan, Simon Streeter, I. Papapanagiotou, G. Fox & Geoff Kneale, 2005, In: Journal of Molecular Biology. 346, 3, p. 689-701 13 p.Research output: Contribution to journal › Article › peer-review
- 2004
- Published
A novel strategy for the expression and purification of the DNA methyltransferase, M.AhdI
P. Marks, Professor John McGeehan & Geoff Kneale, 2004, In: Protein Expression and Purification. 37, 1, p. 236-242 7 p.Research output: Contribution to journal › Article › peer-review
- Published
Complementary or contradictory? the role of dynamic and static light scattering in the biophysical characterization of a zinc finger protein
Professor John McGeehan, X. Provatopoulou, Geoff Kneale, G. Collins & B. Yao, 2004, In: American Biotechnology Laboratory. 22, 9, p. 16-20 5 p.Research output: Contribution to journal › Article
- Published
Crystallization and preliminary X-ray analysis of the controller protein C.AhdI from Aeromonas hydrophilia
Professor John McGeehan, Simon Streeter, J. Cooper, F. Mohammed, G. Fox & Geoff Kneale, 2004, In: Acta Crystallographica Section D. 60, 2, p. 323-325 3 p.Research output: Contribution to journal › Article › peer-review
- Published
DNA footprinting and biophysical characterization of the controller protein C.AhdI suggests the basis of a genetic switch
Simon Streeter, I. Papapanagiotou, Professor John McGeehan & Geoff Kneale, 2004, In: Nucleic Acids Research. 32, 21, p. 6445-6453 9 p.Research output: Contribution to journal › Article › peer-review
- 2003
- Published
Purification and characterisation of a novel DNA methyltransferase, M.AhdI
P. Marks, Professor John McGeehan, Geoff Wilson, N. Errington & Geoff Kneale, 2003, In: Nucleic Acids Research. 31, 11, p. 2803-2810 8 p.Research output: Contribution to journal › Article › peer-review
- 2001
- Published
Evolution of the dUTPase gene of mammalian and avian herpesviruses
Professor John McGeehan, N. Depledge & D. McGeoch, Dec 2001, In: Current Protein and Peptide Science. 2, 4, p. 325-33 9 p.Research output: Contribution to journal › Article › peer-review
- Published
Crystallization and preliminary crystallographic analysis of deoxyuridine 5'-triphosphate nucleotidohydrolase from Bacillus subtilis
R. Persson, M. Harkiolaki, Professor John McGeehan & K. Wilson, Jun 2001, In: Acta Crystallographica Section D Biological Crystallography. 57, 6, p. 876-878 3 p.Research output: Contribution to journal › Article › peer-review
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