Dr Matt Parker
I established, and act as Scientific Director for, the Zebrafish Research Facility at Portsmouth in 2017. In my lab, we adopt a ‘bench to bedside’ approach to study the basis of compulsive behavioural disorders. In our basic research, we use zebrafish as a model species try to understand the biology of compulsive disorders. In particular, we want to understand more about the interaction between molecular (genetic/epigenetic) and environmental (e.g., alcohol, stress) factors that cause compulsive behaviours, and the associated neural circuits, to manifest. Our approach is theoretically guided by the principle that understanding the biology of neuropsychiatric conditions will help develop more effective treatments for patients. This work involves significant amounts of method development, owing to the paucity of validated, reliable measure in zebrafish. We also carry out preclinical/translational research in humans, in particular looking at the interactions of impulsivity/compulsivity and stress on addiction and relapse. In our clinical research, we apply our findings in the laboratory to test important clinical questions relating to compulsive disorders, such as addiction and relapse (in humans) and stereotypic behaviours in domestic, farm and laboratory animals.