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Rosie Graham

Rosie Graham
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Summary

PhD researcher working on new enzymes for degrading plastics: a combined structural and synthetic Biology approach 

Enhancing the dynamics of plastic-degrading enzymes to improve their catalytic activity 

Microbial enzymes that can depolymerise PET (albeit inefficiently) have been discovered, and recently we demonstrated that this PETase can be engineering to enhance its activity. The goal of this project is to further enhance PETase through engineering its dynamic properties drawing on current research into the depolymerisation of natural substances such as cellulose, lignin and collagen. Using a combination of biophysics and structural biology approaches we will work on generating new industrially-relevant enzymes.

ID: 11666704