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Dr Sam Robson

Senior Research Fellow (Bioinformatics)

  1. 2006
  2. c-Myc and downstream targets in the pathogenesis and treatment of cancer

    Dr Samuel Robson, Stella Pelengaris & Michael Khan, 1 Nov 2006, In: Recent Patents on Anti-Cancer Drug Discovery. 1, 3, p. 305-326 22 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2010
  4. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

    Nick Craddock, Matthew E. Hurles, Niall Cardin, Richard D. Pearson, Vincent Plagnol, Dr Samuel Robson, Damjan Vukcevic, Chris Barnes, Donald F. Conrad, Eleni Giannoulatou & 207 others, Chris Holmes, Jonathan L. Marchini, Kathy Stirrups, Martin D. Tobin, Louise V. Wain, Chris Yau, Jan Aerts, Tariq Ahmad, T. Daniel Andrews, Hazel Arbury, Anthony Attwood, Adam Auton, Stephen G. Ball, Anthony J. Balmforth, Jeffrey C. Barrett, Inês Barroso, Anne Barton, Amanda J. Bennett, Sanjeev Bhaskar, Katarzyna Blaszczyk, John Bowes, Oliver J. Brand, Peter S. Braund, Francesca Bredin, Gerome Breen, Morris J. Brown, Ian N. Bruce, Jaswinder Bull, Oliver S. Burren, John Burton, Jake Byrnes, Sian Caesar, Chris M. Clee, Alison J. Coffey, John M. C. Connell, Jason D. Cooper, Anna F. Dominiczak, Kate Downes, Hazel E. Drummond, Darshna Dudakia, Andrew Dunham, Bernadette Ebbs, Diana Eccles, Sarah Edkins, Cathryn Edwards, Anna Elliot, Paul Emery, David M. Evans, Gareth Evans, Steve Eyre, Anne Farmer, I. Nicol Ferrier, Lars Feuk, Tomas Fitzgerald, Edward Flynn, Alistair Forbes, Liz Forty, Jayne A. Franklyn, Rachel M. Freathy, Polly Gibbs, Paul Gilbert, Omer Gokumen, Katherine Gordon-smith, Emma Gray, Elaine Green, Chris J. Groves, Detelina Grozeva, Rhian Gwilliam, Anita Hall, Naomi Hammond, Matt Hardy, Pile Harrison, Neelam Hassanali, Husam Hebaishi, Sarah Hines, Anne Hinks, Graham A Hitman, Lynne Hocking, Eleanor Howard, Philip Howard, Joanna M. M. Howson, Debbie Hughes, Sarah Hunt, John D. Isaacs, Mahim Jain, Derek P. Jewell, Toby Johnson, Jennifer D. Jolley, Ian R. Jones, Lisa A. Jones, George Kirov, Cordelia F. Langford, Hana Lango-allen, G. Mark Lathrop, James Lee, Kate L. Lee, Charlie Lees, Kevin Lewis, Cecilia M. Lindgren, Meeta Maisuria-armer, Julian Maller, John Mansfield, Paul Martin, Dunecan C. O. Massey, Wendy L. Mcardle, Peter Mcguffin, Kirsten E. Mclay, Alex Mentzer, Michael L. Mimmack, Ann E. Morgan, Andrew P. Morris, Craig Mowat, Simon Myers, William Newman, Elaine R. Nimmo, Michael C. O’donovan, Abiodun Onipinla, Ifejinelo Onyiah, Nigel R. Ovington, Michael J. Owen, Kimmo Palin, Kirstie Parnell, David Pernet, John R. B. Perry, Anne Phillips, Dalila Pinto, Natalie J. Prescott, Inga Prokopenko, Michael A. Quail, Suzanne Rafelt, Nigel W. Rayner, Richard Redon, David M. Reid, Anthony Renwick, Susan M. Ring, Neil Robertson, Ellie Russell, David St Clair, Jennifer G. Sambrook, Jeremy D. Sanderson, Helen Schuilenburg, Carol E. Scott, Richard Scott, Sheila Seal, Sue Shaw-hawkins, Beverley M. Shields, Matthew J. Simmonds, Debbie J. Smyth, Elilan Somaskantharajah, Katarina Spanova, Sophia Steer, Jonathan Stephens, Helen E. Stevens, Millicent A. Stone, Zhan Su, Deborah P. M. Symmons, John R. Thompson, Wendy Thomson, Mary E. Travers, Clare Turnbull, Armand Valsesia, Mark Walker, Neil M. Walker, Chris Wallace, Margaret Warren-perry, Nicholas A. Watkins, John Webster, Michael N. Weedon, Anthony G. Wilson, Matthew Woodburn, B. Paul Wordsworth, Allan H. Young, Eleftheria Zeggini, Nigel P. Carter, Timothy M. Frayling, Charles Lee, Gil Mcvean, Patricia B. Munroe, Aarno Palotie, Stephen J. Sawcer, Stephen W. Scherer, David P. Strachan, Chris Tyler-smith, Matthew A. Brown, Paul R. Burton, Mark J. Caulfield, Alastair Compston, Martin Farrall, Stephen C. L. Gough, Alistair S. Hall, Andrew T. Hattersley, Adrian V. S. Hill, Christopher G. Mathew, Marcus Pembrey, Jack Satsangi, Michael R. Stratton, Jane Worthington, Panos Deloukas, Audrey Duncanson, Dominic P. Kwiatkowski, Mark I. Mccarthy, Willem H. Ouwehand, Miles Parkes, Nazneen Rahman, John A. Todd, Nilesh J. Samani & Peter Donnelly, 1 Apr 2010, In: Nature. 464, 7289, p. 713-720 8 p.

    Research output: Contribution to journalArticlepeer-review

  5. Origins and functional impact of copy number variation in the human genome

    Donald F. Conrad, Dalila Pinto, Richard Redon, Lars Feuk, Omer Gokcumen, Yujun Zhang, Jan Aerts, T. Daniel Andrews, Chris Barnes, Peter Campbell & 18 others, Tomas Fitzgerald, Min Hu, Chun Hwa Ihm, Kati Kristiansson, Daniel G. Macarthur, Jeffrey R. Macdonald, Ifejinelo Onyiah, Andy Wing Chun Pang, Dr Samuel Robson, Kathy Stirrups, Armand Valsesia, Klaudia Walter, John Wei, Chris Tyler-smith, Nigel P. Carter, Charles Lee, Stephen W. Scherer & Matthew E. Hurles, 1 Apr 2010, In: Nature. 464, 7289, p. 704-712 9 p.

    Research output: Contribution to journalArticlepeer-review

  6. Nucleosome-interacting proteins regulated by DNA and histone methylation

    Till Bartke, Michiel Vermeulen, Blerta Xhemalce, Dr Samuel Robson, Matthias Mann & Tony Kouzarides, 29 Oct 2010, In: Cell. 143, 3, p. 470-484 15 p.

    Research output: Contribution to journalArticlepeer-review

  7. 2011
  8. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Mark A. Dawson, Rab K. Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-in Chan, Dr Samuel Robson, Chun-wa Chung, Carsten Hopf, Mikhail M. Savitski & 17 others, Carola Huthmacher, Emma Gudgin, Dave Lugo, Soren Beinke, Trevor D. Chapman, Emma J. Roberts, Peter E. Soden, Kurt R. Auger, Olivier Mirguet, Konstanze Doehner, Ruud Delwel, Alan K. Burnett, Phillip Jeffrey, Gerard Drewes, Kevin Lee, Brian J. P. Huntly & Tony Kouzarides, 2 Oct 2011, (Early online) In: Nature. 478, 7370, p. 529-533 5 p.

    Research output: Contribution to journalLetterpeer-review

  9. Deciphering c-MYC-regulated genes in two distinct tissues

    Dr Samuel Robson, Lesley Ward, Helen Brown, Heather Turner, Ewan Hunter, Stella Pelengaris & Michael Khan, 1 Dec 2011, In: BMC Genomics. 12, 1, 476.

    Research output: Contribution to journalArticlepeer-review

  10. 2012
  11. Three distinct patterns of histone H3Y41 phosphorylation mark active genes

    Mark A. Dawson, Samuel D. Foster, Andrew J. Bannister, Dr Samuel Robson, Rebecca Hannah, Xiaonan Wang, Blerta Xhemalce, Andrew D. Wood, Anthony R. Green, Berthold Göttgens & 1 others, Tony Kouzarides, 20 Sep 2012, (Early online) In: Cell Reports. 2, 3, p. 470-477 8 p.

    Research output: Contribution to journalArticlepeer-review

  12. Human RNA methyltransferase BCDIN3D regulates microRNA processing

    Blerta Xhemalce, Dr Samuel Robson & Tony Kouzarides, 11 Oct 2012, In: Cell. 151, 2, p. 278-288 11 p.

    Research output: Contribution to journalArticlepeer-review

  13. 2013
  14. The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

    Gonçalo Castelo-Branco, Paulo P. Amaral, Pär G. Engström, Dr Samuel Robson, Sueli C. Marques, Paul Bertone & Tony Kouzarides, 17 Sep 2013, In: Genome Biology. 14, 9, R98.

    Research output: Contribution to journalArticlepeer-review

  15. 2014
  16. Published

    BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

    B. S. Wyspiańska, Andrew J. Bannister, Isaia Barbieri, J. Nangalia, A. Godfrey, F. J. Calero-nieto, Dr Samuel Robson, I. Rioja, J. Li, M. Wiese & 7 others, E. Cannizzaro, M. A. Dawson, B. J. P. Huntly, Rab K. Prinjha, A. R. Green, B. Gottgens & Tony Kouzarides, 1 Jan 2014, In: Leukaemia. 28, 1, p. 88-97 10 p.

    Research output: Contribution to journalArticlepeer-review

  17. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

    Peter Tessarz, Helena Santos-Rosa, Dr Samuel Robson, Kathrine B. Sylvestersen, Christopher J. Nelson, Michael L. Nielsen & Tony Kouzarides, 23 Jan 2014, In: Nature. 505, 7484, p. 564-568 5 p.

    Research output: Contribution to journalArticlepeer-review

  18. Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

    M. A. Dawson, E. J. Gudgin, S. J. Horton, G. Giotopoulos, E. Meduri, Dr Samuel Robson, E. Cannizzaro, H. Osaki, M. Wiese, S. Putwain & 13 others, C. Y. Fong, C. Grove, J. Craig, Antje Dittmann, D. Lugo, P. Jeffrey, Gerard Drewes, H. K. Lee, L Bullinger, Rab K. Prinjha, Tony Kouzarides, G. S. Vassiliou & B. J. P. Huntly, 1 Feb 2014, In: Leukaemia. 28, 2, p. 311-320 10 p.

    Research output: Contribution to journalArticlepeer-review

  19. Published

    The breast cancer oncogene EMSY Represses transcription of antimetastatic microRNA miR-31

    Emmanuelle Viré, Christina Curtis, Veronica Davalos, Anna Git, Dr Samuel Robson, Alberto Villanueva, August Vidal, Isaia Barbieri, Samuel Aparicio, Manel Esteller & 2 others, Carlos Caldas & Tony Kouzarides, 1 Mar 2014, In: Molecular Cell. 53, 5, p. 806-818 13 p.

    Research output: Contribution to journalArticlepeer-review

  20. 2015
  21. Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy

    S. Picaud, O. Fedorov, A. Thanasopoulou, K. Leonards, K. Jones, J. Meier, H. Olzscha, O. Monteiro, S. Martin, M. Philpott & 27 others, A. Tumber, P. Filippakopoulos, C. Yapp, C. Wells, Ka Hing Che, Andrew J. Bannister, Dr Samuel Robson, U. Kumar, N. Parr, H. K. Lee, D. Lugo, P. Jeffrey, Rod S. Taylor, M. L. Vecellio, C. Bountra, P. E. Brennan, A. O'Mahony, S. Velichko, S. Muller, D. Hay, D. L. Daniels, M. Urh, N. B. La Thangue, Tony Kouzarides, Rab K. Prinjha, J. Schwaller & S. Knapp, 1 Dec 2015, In: Cancer Research. 75, 23, p. 5106-5119 14 p.

    Research output: Contribution to journalArticlepeer-review

  22. 2016
  23. Published

    Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition

    Natalie H. Theodoulou, Paul Bamborough, Andrew J. Bannister, Isabelle Becher, Rino A. Bit, Ka Hing Che, Chun-wa Chung, Antje Dittmann, Gerard Drewes, David H. Drewry & 11 others, Laurie Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Anne-Marie Michon, Judit Molnar, Dr Samuel Robson, Nicholas C. O. Tomkinson, Tony Kouzarides, Rab K. Prinjha & Philip G. Humphreys, 25 Feb 2016, In: Journal of Medicinal Chemistry. 59, 4, p. 1425-1439

    Research output: Contribution to journalArticlepeer-review

  24. A chemical probe for the ATAD2 bromodomain

    Paul Bamborough, Chun-wa Chung, Emmanuel H. Demont, Rebecca C. Furze, Andrew J. Bannister, Ka Hing Che, Hawa Diallo, Clement Douault, Paola Grandi, Tony Kouzarides & 8 others, Anne-Marie Michon, Darren J. Mitchell, Rab K. Prinjha, Christina Rau, Dr Samuel Robson, Robert J. Sheppard, Richard Upton & Robert J. Watson, 12 Sep 2016, In: Angewandte Chemie International Edition. 55, 38, p. 11382-11386 5 p.

    Research output: Contribution to journalArticlepeer-review

  25. 2017
  26. RNA binding by the histone methyltransferases Set1 and Set2

    Camille Sayou, Gonzalo Millán-Zambrano, Helena Santos-Rosa, Elisabeth Petfalski, Dr Samuel Robson, Jonathan Houseley, Tony Kouzarides & David Tollervey, Jul 2017, In: Molecular and Cellular Biology. 37, 14, e00165-17.

    Research output: Contribution to journalArticlepeer-review

  27. A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li, Paulo P. Amaral, Priscilla Cheung, Jan H. Bergmann, Masaki Kinoshita, Tüzer Kalkan, Meryem Ralser, Dr Samuel Robson, Ferdinand von Meyenn, Maike Paramor & 7 others, Fengtang Yang, Caifu Chen, Jennifer Nichols, David L. Spector, Tony Kouzarides, Lin He & Austin Smith, 18 Aug 2017, In: eLife. 6, e23468.

    Research output: Contribution to journalArticlepeer-review

  28. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

    Isaia Barbieri, Konstantinos Tzelepis, Luca Pandolfini, Junwei Shi, Gonzalo Millán-zambrano, Dr Samuel Robson, Demetrios Aspris, Valentina Migliori, Andrew J. Bannister, Namshik Han & 6 others, Etienne De Braekeleer, Hannes Ponstingl, Alan Hendrick, Christopher R. Vakoc, George S. Vassiliou & Tony Kouzarides, 7 Dec 2017, In: Nature. 552, p. 126-131 6 p.

    Research output: Contribution to journalArticlepeer-review

  29. 2018
  30. Published

    Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

    Delphine Larrieu, Emmanuelle Viré, Dr Samuel Robson, Sophia Y. Breusegem, Tony Kouzarides & Stephen P. Jackson, 3 Jul 2018, In: Science Signaling. 11, 537, eaar5401.

    Research output: Contribution to journalArticlepeer-review

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