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Dr Simon Kolstoe

Senior Lecturer

Simon Kolstoe


My academic and research interests are in the area of research systems and methodology, specifically how research ethics, governance and integrity processes can impact medical and human participant research. I chair research ethics committees for the NHS, Ministry of Defence and Public Health England, and sit on a variety of advisory boards including the Department of Health's Confidentiality Advisory Group (CAG).

I originally gained a first class BSc in Biomedical Science at the University of Southampton before joining the laboratory of Professor Steve Wood for a PhD in Biochemistry. My doctoral project involved the use of X-ray crystallography in rational drug design for the pentraxin family of proteins. In 2005 I took up a post-doctoral position working for Professor Sir Mark Pepys FRS at the Centre for Amyloidosis and Acute Phase Proteins, UCL Medical School. In 2006 our work on a depleter of C-reactive protein was published on the front cover of Nature. A second project, developing small molecules targeting the serum protein Transthyretin, contributed towards the group being awarded one of the first Wellcome Trust Seeding Drug Discovery Initiative awards in 2007. This latter work was subsequently patented and licensed to GSK in 2009. I joined the University of Portsmouth in April 2012 as a tenure-track Senior Fellow, and in 2014 received a BBSRC project grant to explore immune proteins, protein-DNA interactions and the use of mammalian cell lines for producing recombinant protein for biophysical characterisation.

While carrying out biomedical research I became increasingly interested in research systems and methodologies. Following an additional bachelors degree in Philosophy and then Master’s degree in Research Ethics, I moved to the School of Health Care Professions in 2017 where alongside my research I teach evidence based healthcare.

Research Interests

  • Research Ethics, Integrity and Governance
  • Ethics committee review: quality and consistency
  • Outcome reporting bias
  • Research Waste
  • Research Culture
  • Clinical Research Design
  • Human Challenge Trials

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