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A carboxymethyl cellulose bone graft carrier delays early bone healing in an ovine model

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A limitation in the use of calcium phosphate (CaP) is that in its raw form, it comprises blocks or granules, which are limited in their utility for orthopedic surgery and a number of commercial bone grafts are supplied within an aqueous based carboxymethyl cellulose (CMC) putty. Our hypothesis was that CMC combined with a porous silicate‐substituted CaP (SiCaP) scaffold would have no negative effect on bone formation after implantation in an ovine femoral condyle. Defects were either (a) empty or filled with (b) SiCaP granules, (c) CMC‐SiCaP Putty or (d) a SiCaP press‐fit dry block. Scaffolds were identical in composition and remained in vivo for 4, 8, and 12 weeks. Bone apposition rates, bone area, percentage of bone‐implant contact and graft area were quantified. At 4 and 8 weeks, significantly more new bone and percentage of bone‐implant contact was measured within granules when compared with both putty and block scaffolds. At 12 weeks, significantly increased bone was measured for the granules when compared with blocks and no significant difference was found when the granules and putty scaffolds were compared. Results showed the disadvantageous effect that CMC may have on early bone growth and that granules increased new bone formation when compared with a press‐fit block composed of the same material.
Original languageEnglish
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Early online date21 May 2019
Publication statusEarly online - 21 May 2019


  • A Carboxymethyl Cellulose Bone Graft

    Rights statement: This is the peer reviewed version of the following article: Coathup, M, Campion, C, Blunn, G. A carboxymethyl cellulose bone graft carrier delays early bone healing in an ovine model. J Biomed Mater Res. 2019; 1– 7., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

    Accepted author manuscript (Post-print), 1.53 MB, PDF document

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