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A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors

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A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors. / Tremblay, Patrick; Dietrich, Susanne; Mericskay, Mathias; Schubert, Frank R.; Li, Zhenlin; Paulin, Denise.

In: Developmental Biology, Vol. 203, No. 1, 01.11.1998, p. 49-61.

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Tremblay, Patrick ; Dietrich, Susanne ; Mericskay, Mathias ; Schubert, Frank R. ; Li, Zhenlin ; Paulin, Denise. / A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors. In: Developmental Biology. 1998 ; Vol. 203, No. 1. pp. 49-61.

Bibtex

@article{b428533919454a29a076b2d2986ed056,
title = "A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors",
abstract = "Activated by dorsalizing and lateralizing signals, the Pax3 gene is an early marker for the entire paraxial mesoderm and its dorsal derivative, the dermomyotome. Later, its expression becomes restricted to the lateral dermomyotome and to the migratory muscle precursors giving rise to the hypaxial musculature. To understand better the role that Pax3 plays during development of paraxial mesoderm-derived structures, we followed the development of the musculature and skeleton in the murine Pax3 mutant Splotch. We found that the mutant dermomyotomes and myotomes failed to organize and to elongate medially and laterally, leading to the reduction and malformation of the entire trunk musculature. Mutants lacked ventral aspects of the body wall musculature and muscles derived from migratory myoblasts, suggesting a crucial function for Pax3 in the long-range migration of muscle precursors giving rise to the ventral hypaxial musculature. In addition, severe malformations were detected in the skeleton. The axial and appendicular skeleton displayed malformations and in particular multiple bone fusions.",
keywords = "Animals, Bone Development, DNA-Binding Proteins, Embryonic and Fetal Development, Gene Expression Regulation, Developmental, Histocytochemistry, Lac Operon, Mesoderm, Mice, Mice, Transgenic, Muscle Development, Muscle, Skeletal, Mutation, Paired Box Transcription Factors, Transcription Factors, Transgenes",
author = "Patrick Tremblay and Susanne Dietrich and Mathias Mericskay and Schubert, {Frank R.} and Zhenlin Li and Denise Paulin",
note = "Copyright 1998 Academic Press.",
year = "1998",
month = nov,
day = "1",
doi = "10.1006/dbio.1998.9041",
language = "English",
volume = "203",
pages = "49--61",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors

AU - Tremblay, Patrick

AU - Dietrich, Susanne

AU - Mericskay, Mathias

AU - Schubert, Frank R.

AU - Li, Zhenlin

AU - Paulin, Denise

N1 - Copyright 1998 Academic Press.

PY - 1998/11/1

Y1 - 1998/11/1

N2 - Activated by dorsalizing and lateralizing signals, the Pax3 gene is an early marker for the entire paraxial mesoderm and its dorsal derivative, the dermomyotome. Later, its expression becomes restricted to the lateral dermomyotome and to the migratory muscle precursors giving rise to the hypaxial musculature. To understand better the role that Pax3 plays during development of paraxial mesoderm-derived structures, we followed the development of the musculature and skeleton in the murine Pax3 mutant Splotch. We found that the mutant dermomyotomes and myotomes failed to organize and to elongate medially and laterally, leading to the reduction and malformation of the entire trunk musculature. Mutants lacked ventral aspects of the body wall musculature and muscles derived from migratory myoblasts, suggesting a crucial function for Pax3 in the long-range migration of muscle precursors giving rise to the ventral hypaxial musculature. In addition, severe malformations were detected in the skeleton. The axial and appendicular skeleton displayed malformations and in particular multiple bone fusions.

AB - Activated by dorsalizing and lateralizing signals, the Pax3 gene is an early marker for the entire paraxial mesoderm and its dorsal derivative, the dermomyotome. Later, its expression becomes restricted to the lateral dermomyotome and to the migratory muscle precursors giving rise to the hypaxial musculature. To understand better the role that Pax3 plays during development of paraxial mesoderm-derived structures, we followed the development of the musculature and skeleton in the murine Pax3 mutant Splotch. We found that the mutant dermomyotomes and myotomes failed to organize and to elongate medially and laterally, leading to the reduction and malformation of the entire trunk musculature. Mutants lacked ventral aspects of the body wall musculature and muscles derived from migratory myoblasts, suggesting a crucial function for Pax3 in the long-range migration of muscle precursors giving rise to the ventral hypaxial musculature. In addition, severe malformations were detected in the skeleton. The axial and appendicular skeleton displayed malformations and in particular multiple bone fusions.

KW - Animals

KW - Bone Development

KW - DNA-Binding Proteins

KW - Embryonic and Fetal Development

KW - Gene Expression Regulation, Developmental

KW - Histocytochemistry

KW - Lac Operon

KW - Mesoderm

KW - Mice

KW - Mice, Transgenic

KW - Muscle Development

KW - Muscle, Skeletal

KW - Mutation

KW - Paired Box Transcription Factors

KW - Transcription Factors

KW - Transgenes

U2 - 10.1006/dbio.1998.9041

DO - 10.1006/dbio.1998.9041

M3 - Article

C2 - 9806772

VL - 203

SP - 49

EP - 61

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 1

ER -

ID: 1263354