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A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant: regeneration of a neo-enthesis in vivo

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A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant : regeneration of a neo-enthesis in vivo. / Pendegrass, C J; Oddy, M J; Cannon, S R; Briggs, T; Goodship, A E; Blunn, G W.

In: Journal of Orthopaedic Research, Vol. 22, No. 6, 11.2004, p. 1316-24.

Research output: Contribution to journalArticlepeer-review

Harvard

Pendegrass, CJ, Oddy, MJ, Cannon, SR, Briggs, T, Goodship, AE & Blunn, GW 2004, 'A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant: regeneration of a neo-enthesis in vivo', Journal of Orthopaedic Research, vol. 22, no. 6, pp. 1316-24. https://doi.org/10.1016/j.orthres.2004.03.022

APA

Pendegrass, C. J., Oddy, M. J., Cannon, S. R., Briggs, T., Goodship, A. E., & Blunn, G. W. (2004). A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant: regeneration of a neo-enthesis in vivo. Journal of Orthopaedic Research, 22(6), 1316-24. https://doi.org/10.1016/j.orthres.2004.03.022

Vancouver

Author

Pendegrass, C J ; Oddy, M J ; Cannon, S R ; Briggs, T ; Goodship, A E ; Blunn, G W. / A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant : regeneration of a neo-enthesis in vivo. In: Journal of Orthopaedic Research. 2004 ; Vol. 22, No. 6. pp. 1316-24.

Bibtex

@article{2f26d1879b75441f9a536df9e97cf65e,
title = "A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant: regeneration of a neo-enthesis in vivo",
abstract = "The attachment of tendons and ligaments to massive endoprostheses remains a clinical challenge due to the difficulty in achieving a soft tissue implant interface with a mechanical strength sufficient to transmit the forces necessary for locomotion. We have used an in vivo animal model to study patellar tendon attachment to an implant surface. The interface generated when the patellar tendon was attached to a hydroxyapatite (HA) coated implant was examined using light microscopy and a quantitative histomorphological analysis was performed. In the Autograft Group, the interface was augmented with autogenous cancellous bone and marrow graft, and at six weeks an indirect-like insertion was observed. At twelve weeks, the interface was observed to be a layered neo-enthesis, whose morphology was similar to a normal direct tendon insertion. In the HA Group, the tendon-implant interface was not augmented, and the implant was enveloped by a dense collagenous fibrous tissue. This study shows that a tendon-implant neo-enthesis can develop in situ by employing a suitable implant surface in association with biological augmentation.",
keywords = "Animals, Coated Materials, Biocompatible, Durapatite, Female, Knee Joint, Models, Animal, Osseointegration, Patella, Postoperative Complications, Prostheses and Implants, Sheep, Tendons, Journal Article, Research Support, Non-U.S. Gov't",
author = "Pendegrass, {C J} and Oddy, {M J} and Cannon, {S R} and T Briggs and Goodship, {A E} and Blunn, {G W}",
year = "2004",
month = nov,
doi = "10.1016/j.orthres.2004.03.022",
language = "English",
volume = "22",
pages = "1316--24",
journal = "Journal of Orthopaedic Research",
issn = "0736-0266",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - A histomorphological study of tendon reconstruction to a hydroxyapatite-coated implant

T2 - regeneration of a neo-enthesis in vivo

AU - Pendegrass, C J

AU - Oddy, M J

AU - Cannon, S R

AU - Briggs, T

AU - Goodship, A E

AU - Blunn, G W

PY - 2004/11

Y1 - 2004/11

N2 - The attachment of tendons and ligaments to massive endoprostheses remains a clinical challenge due to the difficulty in achieving a soft tissue implant interface with a mechanical strength sufficient to transmit the forces necessary for locomotion. We have used an in vivo animal model to study patellar tendon attachment to an implant surface. The interface generated when the patellar tendon was attached to a hydroxyapatite (HA) coated implant was examined using light microscopy and a quantitative histomorphological analysis was performed. In the Autograft Group, the interface was augmented with autogenous cancellous bone and marrow graft, and at six weeks an indirect-like insertion was observed. At twelve weeks, the interface was observed to be a layered neo-enthesis, whose morphology was similar to a normal direct tendon insertion. In the HA Group, the tendon-implant interface was not augmented, and the implant was enveloped by a dense collagenous fibrous tissue. This study shows that a tendon-implant neo-enthesis can develop in situ by employing a suitable implant surface in association with biological augmentation.

AB - The attachment of tendons and ligaments to massive endoprostheses remains a clinical challenge due to the difficulty in achieving a soft tissue implant interface with a mechanical strength sufficient to transmit the forces necessary for locomotion. We have used an in vivo animal model to study patellar tendon attachment to an implant surface. The interface generated when the patellar tendon was attached to a hydroxyapatite (HA) coated implant was examined using light microscopy and a quantitative histomorphological analysis was performed. In the Autograft Group, the interface was augmented with autogenous cancellous bone and marrow graft, and at six weeks an indirect-like insertion was observed. At twelve weeks, the interface was observed to be a layered neo-enthesis, whose morphology was similar to a normal direct tendon insertion. In the HA Group, the tendon-implant interface was not augmented, and the implant was enveloped by a dense collagenous fibrous tissue. This study shows that a tendon-implant neo-enthesis can develop in situ by employing a suitable implant surface in association with biological augmentation.

KW - Animals

KW - Coated Materials, Biocompatible

KW - Durapatite

KW - Female

KW - Knee Joint

KW - Models, Animal

KW - Osseointegration

KW - Patella

KW - Postoperative Complications

KW - Prostheses and Implants

KW - Sheep

KW - Tendons

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.orthres.2004.03.022

DO - 10.1016/j.orthres.2004.03.022

M3 - Article

C2 - 15475215

VL - 22

SP - 1316

EP - 1324

JO - Journal of Orthopaedic Research

JF - Journal of Orthopaedic Research

SN - 0736-0266

IS - 6

ER -

ID: 8582543