A pilot study to investigate the associations of urinary concentrations of urinary NO, ATP and derivatives with overactive bladder symptom severity
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Recruited participants completed a questionnaire to measure the severity of OAB-associated urinary symptoms and provided a mid-stream urine sample. Following identification of infection and hematuria using microbiology and microscopy, 95 samples were subjected to assays to measure NO, NO2-, NO3-, ATP, ADP and creatinine.
There was no correlation between [NO/Cr], [NO2-/Cr] or [NO3-/Cr] and overall OAB symptom severity. [ATP/NO], [ADP/NO] and a combination of these, [ATP/Cr*ADP/Cr]/[NO/Cr], correlated with OAB symptom severity; with [ATP/Cr*ADP/Cr]/[NO/Cr] also correlating with the severity of urinary frequency and urgency.
This study adds to a growing literature that demonstrates the potential of urinary biomarkers and provides a foundation for a larger, longitudinal study.
|Early online date||14 Mar 2020|
|Publication status||Early online - 14 Mar 2020|
Rights statement: This is the peer reviewed version of the following article: Firouzmand, S. and Young, J.S. (2020), A pilot study to investigate the associations of urinary concentrations of urinary NO, ATP and derivatives with overactive bladder symptom severity. Exp Physiol. Accepted Author Manuscript, which has been published in final form at doi:10.1113/EP088450. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Accepted author manuscript (Post-print), 1.59 MB, PDF document