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A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance

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A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance. / Ameline, Camille; Bourgeois, Yann; Vögtli, Felix; Savola, Eevi; Andras, Jason; Engelstädter, Jan; Ebert, Dieter.

In: Molecular Biology and Evolution, Vol. 0, msaa311, 01.12.2020, p. 0.

Research output: Contribution to journalArticlepeer-review

Harvard

Ameline, C, Bourgeois, Y, Vögtli, F, Savola, E, Andras, J, Engelstädter, J & Ebert, D 2020, 'A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance', Molecular Biology and Evolution, vol. 0, msaa311, pp. 0. https://doi.org/10.1093/molbev/msaa311

APA

Ameline, C., Bourgeois, Y., Vögtli, F., Savola, E., Andras, J., Engelstädter, J., & Ebert, D. (2020). A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance. Molecular Biology and Evolution, 0, 0. [msaa311]. https://doi.org/10.1093/molbev/msaa311

Vancouver

Ameline C, Bourgeois Y, Vögtli F, Savola E, Andras J, Engelstädter J et al. A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance. Molecular Biology and Evolution. 2020 Dec 1;0:0. msaa311. https://doi.org/10.1093/molbev/msaa311

Author

Ameline, Camille ; Bourgeois, Yann ; Vögtli, Felix ; Savola, Eevi ; Andras, Jason ; Engelstädter, Jan ; Ebert, Dieter. / A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance. In: Molecular Biology and Evolution. 2020 ; Vol. 0. pp. 0.

Bibtex

@article{540db07d9f8f46d8b80cbb369190b49b,
title = "A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance",
abstract = "Parasites are a major evolutionary force, driving adaptive responses in host populations. Although the link between phenotypic response to parasite-mediated natural selection and the underlying genetic architecture often remains obscure, this link is crucial for understanding the evolution of resistance and predicting associated allele frequency changes in the population. To close this gap, we monitored the response to selection during epidemics of a virulent bacterial pathogen, Pasteuria ramosa, in a natural host population of Daphnia magna. Across two epidemics, we observed a strong increase in the proportion of resistant phenotypes as the epidemics progressed. Field and laboratory experiments confirmed that this increase in resistance was caused by selection from the local parasite. Using a genome wide association study (GWAS), we built a genetic model in which two genomic regions with dominance and epistasis control resistance polymorphism in the host. We verified this model by selfing host genotypes with different resistance phenotypes and scoring their F1 for segregation of resistance and associated genetic markers. Such epistatic effects with strong fitness consequences in host-parasite coevolution are believed to be crucial in the Red Queen model for the evolution of genetic recombination.",
keywords = "parasite-mediated selection, zooplankton, resistance, genetic architecture, epistasis, dominance, multilocus genetics, Daphnia magna, Pasteuria ramosa",
author = "Camille Ameline and Yann Bourgeois and Felix V{\"o}gtli and Eevi Savola and Jason Andras and Jan Engelst{\"a}dter and Dieter Ebert",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.",
year = "2020",
month = dec,
day = "1",
doi = "10.1093/molbev/msaa311",
language = "English",
volume = "0",
pages = "0",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance

AU - Ameline, Camille

AU - Bourgeois, Yann

AU - Vögtli, Felix

AU - Savola, Eevi

AU - Andras, Jason

AU - Engelstädter, Jan

AU - Ebert, Dieter

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Parasites are a major evolutionary force, driving adaptive responses in host populations. Although the link between phenotypic response to parasite-mediated natural selection and the underlying genetic architecture often remains obscure, this link is crucial for understanding the evolution of resistance and predicting associated allele frequency changes in the population. To close this gap, we monitored the response to selection during epidemics of a virulent bacterial pathogen, Pasteuria ramosa, in a natural host population of Daphnia magna. Across two epidemics, we observed a strong increase in the proportion of resistant phenotypes as the epidemics progressed. Field and laboratory experiments confirmed that this increase in resistance was caused by selection from the local parasite. Using a genome wide association study (GWAS), we built a genetic model in which two genomic regions with dominance and epistasis control resistance polymorphism in the host. We verified this model by selfing host genotypes with different resistance phenotypes and scoring their F1 for segregation of resistance and associated genetic markers. Such epistatic effects with strong fitness consequences in host-parasite coevolution are believed to be crucial in the Red Queen model for the evolution of genetic recombination.

AB - Parasites are a major evolutionary force, driving adaptive responses in host populations. Although the link between phenotypic response to parasite-mediated natural selection and the underlying genetic architecture often remains obscure, this link is crucial for understanding the evolution of resistance and predicting associated allele frequency changes in the population. To close this gap, we monitored the response to selection during epidemics of a virulent bacterial pathogen, Pasteuria ramosa, in a natural host population of Daphnia magna. Across two epidemics, we observed a strong increase in the proportion of resistant phenotypes as the epidemics progressed. Field and laboratory experiments confirmed that this increase in resistance was caused by selection from the local parasite. Using a genome wide association study (GWAS), we built a genetic model in which two genomic regions with dominance and epistasis control resistance polymorphism in the host. We verified this model by selfing host genotypes with different resistance phenotypes and scoring their F1 for segregation of resistance and associated genetic markers. Such epistatic effects with strong fitness consequences in host-parasite coevolution are believed to be crucial in the Red Queen model for the evolution of genetic recombination.

KW - parasite-mediated selection

KW - zooplankton

KW - resistance

KW - genetic architecture

KW - epistasis

KW - dominance

KW - multilocus genetics

KW - Daphnia magna

KW - Pasteuria ramosa

U2 - 10.1093/molbev/msaa311

DO - 10.1093/molbev/msaa311

M3 - Article

C2 - 33258959

VL - 0

SP - 0

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

M1 - msaa311

ER -

ID: 25827843