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Active targeting

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Actively targeted nanomedicines are drug delivery systems based on nanocarriers loaded with a therapeutic and/or imaging agent in which a targeting moiety has been attached onto their surface, with the aim of targeting and interacting with a specific receptor, in order to elicit their effect. Three major components should be carefully considered in order to design an optimal nanomedicine including: the nanocarrier (e.g. liposomes, particles, dendrimers, micelles), the targeting moiety (e.g. proteins, peptides, oligonucleotides, carbohydrates), and the therapeutic and/or imaging agent. Nowadays, promising approaches have been developed, especially in the field of cancer and central nervous system diseases. However, very few active targeted nanomedicines have progressed from the proof-of-concept to clinical trials.
Original languageEnglish
Title of host publicationFundamentals of pharmaceutical nanoscience
EditorsIjeoma F. Uchegbu, Andreas G. Schatzlein, Woei Ping Cheng, Aikaterini Lalatsa
Place of PublicationNew York
PublisherSpringer
Pages337
Number of pages374
ISBN (Electronic)9781461491644
ISBN (Print)9781461491637
DOIs
Publication statusPublished - 2013

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