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An electroactive oligo‐EDOT platform for neural tissue engineering

Research output: Contribution to journalArticle

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An electroactive oligo‐EDOT platform for neural tissue engineering. / Ritzau‐Reid, Kaja I.; Spicer, Christopher D.; Gelmi, Amy; Grigsby, Christopher L.; Ponder, James F.; Bemmer, Victoria; Creamer, Adam; Vilar, Ramon; Serio, Andrea; Stevens, Molly M.

In: Advanced Functional Materials, 14.08.2020.

Research output: Contribution to journalArticle

Harvard

Ritzau‐Reid, KI, Spicer, CD, Gelmi, A, Grigsby, CL, Ponder, JF, Bemmer, V, Creamer, A, Vilar, R, Serio, A & Stevens, MM 2020, 'An electroactive oligo‐EDOT platform for neural tissue engineering', Advanced Functional Materials. https://doi.org/10.1002/adfm.202003710

APA

Ritzau‐Reid, K. I., Spicer, C. D., Gelmi, A., Grigsby, C. L., Ponder, J. F., Bemmer, V., Creamer, A., Vilar, R., Serio, A., & Stevens, M. M. (2020). An electroactive oligo‐EDOT platform for neural tissue engineering. Advanced Functional Materials, [2003710]. https://doi.org/10.1002/adfm.202003710

Vancouver

Ritzau‐Reid KI, Spicer CD, Gelmi A, Grigsby CL, Ponder JF, Bemmer V et al. An electroactive oligo‐EDOT platform for neural tissue engineering. Advanced Functional Materials. 2020 Aug 14. 2003710. https://doi.org/10.1002/adfm.202003710

Author

Ritzau‐Reid, Kaja I. ; Spicer, Christopher D. ; Gelmi, Amy ; Grigsby, Christopher L. ; Ponder, James F. ; Bemmer, Victoria ; Creamer, Adam ; Vilar, Ramon ; Serio, Andrea ; Stevens, Molly M. / An electroactive oligo‐EDOT platform for neural tissue engineering. In: Advanced Functional Materials. 2020.

Bibtex

@article{6c95413ca47b42f6a4f06b3ab36d9c16,
title = "An electroactive oligo‐EDOT platform for neural tissue engineering",
abstract = "The unique electrochemical properties of the conductive polymer poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4‐ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end‐capping strategy, into block co‐polymers. By exploiting end‐functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co‐polymer is produced that is electroactive, processable, and bio‐compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.",
keywords = "RCUK, EPSRC, EP/L016737/1, MRC, MR/K026666/1, Wellcome Trust, 213949/Z/18/Z, 3,4‐ethylenedioxythiophene, biomaterials, electrospinning, neurite outgrowth, tissue engineering",
author = "Ritzau‐Reid, {Kaja I.} and Spicer, {Christopher D.} and Amy Gelmi and Grigsby, {Christopher L.} and Ponder, {James F.} and Victoria Bemmer and Adam Creamer and Ramon Vilar and Andrea Serio and Stevens, {Molly M.}",
year = "2020",
month = aug,
day = "14",
doi = "10.1002/adfm.202003710",
language = "English",
journal = "Advanced Functional Materials",
issn = "1616-301X",

}

RIS

TY - JOUR

T1 - An electroactive oligo‐EDOT platform for neural tissue engineering

AU - Ritzau‐Reid, Kaja I.

AU - Spicer, Christopher D.

AU - Gelmi, Amy

AU - Grigsby, Christopher L.

AU - Ponder, James F.

AU - Bemmer, Victoria

AU - Creamer, Adam

AU - Vilar, Ramon

AU - Serio, Andrea

AU - Stevens, Molly M.

PY - 2020/8/14

Y1 - 2020/8/14

N2 - The unique electrochemical properties of the conductive polymer poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4‐ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end‐capping strategy, into block co‐polymers. By exploiting end‐functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co‐polymer is produced that is electroactive, processable, and bio‐compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

AB - The unique electrochemical properties of the conductive polymer poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4‐ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end‐capping strategy, into block co‐polymers. By exploiting end‐functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co‐polymer is produced that is electroactive, processable, and bio‐compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

KW - RCUK

KW - EPSRC

KW - EP/L016737/1

KW - MRC

KW - MR/K026666/1

KW - Wellcome Trust

KW - 213949/Z/18/Z

KW - 3,4‐ethylenedioxythiophene

KW - biomaterials

KW - electrospinning

KW - neurite outgrowth

KW - tissue engineering

UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202003710

U2 - 10.1002/adfm.202003710

DO - 10.1002/adfm.202003710

M3 - Article

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

M1 - 2003710

ER -

ID: 22579094