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An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus

Research output: Contribution to journalArticlepeer-review

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An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus. / Smart, John D.; Dunkley, Sian; Tsibouklis, John; Young, Simon.

In: International Journal of Pharmaceutics, Vol. 496, No. 2, 01.12.2015, p. 299-303.

Research output: Contribution to journalArticlepeer-review

Harvard

Smart, JD, Dunkley, S, Tsibouklis, J & Young, S 2015, 'An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus', International Journal of Pharmaceutics, vol. 496, no. 2, pp. 299-303. https://doi.org/10.1016/j.ijpharm.2015.10.014

APA

Smart, J. D., Dunkley, S., Tsibouklis, J., & Young, S. (2015). An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus. International Journal of Pharmaceutics, 496(2), 299-303. https://doi.org/10.1016/j.ijpharm.2015.10.014

Vancouver

Smart JD, Dunkley S, Tsibouklis J, Young S. An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus. International Journal of Pharmaceutics. 2015 Dec 1;496(2):299-303. https://doi.org/10.1016/j.ijpharm.2015.10.014

Author

Smart, John D. ; Dunkley, Sian ; Tsibouklis, John ; Young, Simon. / An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus. In: International Journal of Pharmaceutics. 2015 ; Vol. 496, No. 2. pp. 299-303.

Bibtex

@article{fac0ac7aa5644ae68f8a65ae42539d37,
title = "An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus",
abstract = "There is a requirement for the development of oral dosage forms that are adhesive and allow extended oesophageal residence time for localised therapies, or are non-adhesive for ease of swallowing. This study provides an initial assessment of the in vitro oesophageal retention characteristics of several widely utilised pharmaceutical coating materials. To this end, a previously described apparatus has been used to measure the force required to pull a coated disc-shaped model tablet across a section of excised oesophageal tissue. Of the materials tested, the well-studied mucoadhesive polymer sodium alginate was found to be associated with significant oesophageal adhesion properties that was capable of {\textquoteleft}self-repairing{\textquoteright}. Hydroxypropylmethylcellulose exhibited less pronounced bioadhesive behaviour and blending this with plasticiser or with low molecular weight polymers and surfactants did not significantly affect this. Low molecular weight water soluble polymers, were found to behave similarly to the uncoated glass control disc. Polysorbates exhibited bioadhesion behaviour that was majorly influenced by the nature of the surfactant. The insoluble polymer ethylcellulose, and the relatively lipophilic surfactant sorbitan monooleate were seen to move more readily than the uncoated disc, suggesting that these may have a role as {\textquoteleft}easy-to-swallow{\textquoteright} coatings.",
keywords = "Oesophageal adhesion, Easy-to-swallow, Mucoadhesion, Non-adhesive coatings",
author = "Smart, {John D.} and Sian Dunkley and John Tsibouklis and Simon Young",
note = "Accepted - 03/10/2015 Published online - 21/10/2015",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.ijpharm.2015.10.014",
language = "English",
volume = "496",
pages = "299--303",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus

AU - Smart, John D.

AU - Dunkley, Sian

AU - Tsibouklis, John

AU - Young, Simon

N1 - Accepted - 03/10/2015 Published online - 21/10/2015

PY - 2015/12/1

Y1 - 2015/12/1

N2 - There is a requirement for the development of oral dosage forms that are adhesive and allow extended oesophageal residence time for localised therapies, or are non-adhesive for ease of swallowing. This study provides an initial assessment of the in vitro oesophageal retention characteristics of several widely utilised pharmaceutical coating materials. To this end, a previously described apparatus has been used to measure the force required to pull a coated disc-shaped model tablet across a section of excised oesophageal tissue. Of the materials tested, the well-studied mucoadhesive polymer sodium alginate was found to be associated with significant oesophageal adhesion properties that was capable of ‘self-repairing’. Hydroxypropylmethylcellulose exhibited less pronounced bioadhesive behaviour and blending this with plasticiser or with low molecular weight polymers and surfactants did not significantly affect this. Low molecular weight water soluble polymers, were found to behave similarly to the uncoated glass control disc. Polysorbates exhibited bioadhesion behaviour that was majorly influenced by the nature of the surfactant. The insoluble polymer ethylcellulose, and the relatively lipophilic surfactant sorbitan monooleate were seen to move more readily than the uncoated disc, suggesting that these may have a role as ‘easy-to-swallow’ coatings.

AB - There is a requirement for the development of oral dosage forms that are adhesive and allow extended oesophageal residence time for localised therapies, or are non-adhesive for ease of swallowing. This study provides an initial assessment of the in vitro oesophageal retention characteristics of several widely utilised pharmaceutical coating materials. To this end, a previously described apparatus has been used to measure the force required to pull a coated disc-shaped model tablet across a section of excised oesophageal tissue. Of the materials tested, the well-studied mucoadhesive polymer sodium alginate was found to be associated with significant oesophageal adhesion properties that was capable of ‘self-repairing’. Hydroxypropylmethylcellulose exhibited less pronounced bioadhesive behaviour and blending this with plasticiser or with low molecular weight polymers and surfactants did not significantly affect this. Low molecular weight water soluble polymers, were found to behave similarly to the uncoated glass control disc. Polysorbates exhibited bioadhesion behaviour that was majorly influenced by the nature of the surfactant. The insoluble polymer ethylcellulose, and the relatively lipophilic surfactant sorbitan monooleate were seen to move more readily than the uncoated disc, suggesting that these may have a role as ‘easy-to-swallow’ coatings.

KW - Oesophageal adhesion

KW - Easy-to-swallow

KW - Mucoadhesion

KW - Non-adhesive coatings

U2 - 10.1016/j.ijpharm.2015.10.014

DO - 10.1016/j.ijpharm.2015.10.014

M3 - Article

VL - 496

SP - 299

EP - 303

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 3385968