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An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions

Research output: Contribution to journal › Article › peer-review

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An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions. / Riley, Robert G.; Smart, John D.; Tsibouklis, John; Young, Simon A.; Hampson, Frank; Davis, Alf; Kelly, Grant; Dettmar, Peter W.; Wilber, William R.

In: International Journal of Pharmaceutics, Vol. 236, No. 1-2, 02.04.2002, p. 87-96.

Research output: Contribution to journal › Article › peer-review

Harvard

Riley, RG, Smart, JD, Tsibouklis, J, Young, SA, Hampson, F, Davis, A, Kelly, G, Dettmar, PW & Wilber, WR 2002, 'An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions', International Journal of Pharmaceutics, vol. 236, no. 1-2, pp. 87-96. https://doi.org/10.1016/S0378-5173(02)00014-5

APA

Riley, R. G., Smart, J. D., Tsibouklis, J., Young, S. A., Hampson, F., Davis, A., Kelly, G., Dettmar, P. W., & Wilber, W. R. (2002). An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions. International Journal of Pharmaceutics, 236(1-2), 87-96. https://doi.org/10.1016/S0378-5173(02)00014-5

Vancouver

Riley RG, Smart JD, Tsibouklis J, Young SA, Hampson F, Davis A et al. An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions. International Journal of Pharmaceutics. 2002 Apr 2;236(1-2):87-96. https://doi.org/10.1016/S0378-5173(02)00014-5

Author

Riley, Robert G. ; Smart, John D. ; Tsibouklis, John ; Young, Simon A. ; Hampson, Frank ; Davis, Alf ; Kelly, Grant ; Dettmar, Peter W. ; Wilber, William R. / An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions. In: International Journal of Pharmaceutics. 2002 ; Vol. 236, No. 1-2. pp. 87-96.

Bibtex

@article{e936806996334b87881659e72475ba9b,
title = "An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions",
abstract = "Polymers that bind from solution onto gastric mucosae can be used as a means of facilitating localised drug delivery, or act as therapeutic agents in their own right (e.g. by forming a protective layer or by inhibiting enzymes). Previous workers have used semi-quantitative methods to identify the ability of commercially available poly(acrylic acid)s to bind to gastric mucosa. In this study, the binding and retention of labelled poly(acrylic acid)s to sections of gastric mucosa from the pyloric region of pigs stomach were evaluated using 'static' and 'dynamic flow' test systems. Dispersions (3%) of 'low', 'high' and 'ultra high' (cross-linked) polymers were seen to adhere to porcine pyloric mucosa after exposure and rinsing in the 'static' system. The high molecular weight polymer showed the greatest retention in the 'dynamic' test system when washing continuously with simulated gastric acid. Changing the pH of the dispersions from 4.3 to 6.2 had little effect on polymer retention. It was concluded that polymers that were sufficiently mobile in solution to spread on, and interact with, the mucosal surface, but had a sufficiently high molecular weight to form viscous solutions and/or bioadhere to the mucosa, may be retained on the mucosal surface for the longest periods.",
keywords = "Bioadhesion, Gastric mucosa, Mucoadhesion, Poly(acrylic acid)s",
author = "Riley, {Robert G.} and Smart, {John D.} and John Tsibouklis and Young, {Simon A.} and Frank Hampson and Alf Davis and Grant Kelly and Dettmar, {Peter W.} and Wilber, {William R.}",
year = "2002",
month = apr,
day = "2",
doi = "10.1016/S0378-5173(02)00014-5",
language = "English",
volume = "236",
pages = "87--96",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions

AU - Riley, Robert G.

AU - Smart, John D.

AU - Tsibouklis, John

AU - Young, Simon A.

AU - Hampson, Frank

AU - Davis, Alf

AU - Kelly, Grant

AU - Dettmar, Peter W.

AU - Wilber, William R.

PY - 2002/4/2

Y1 - 2002/4/2

N2 - Polymers that bind from solution onto gastric mucosae can be used as a means of facilitating localised drug delivery, or act as therapeutic agents in their own right (e.g. by forming a protective layer or by inhibiting enzymes). Previous workers have used semi-quantitative methods to identify the ability of commercially available poly(acrylic acid)s to bind to gastric mucosa. In this study, the binding and retention of labelled poly(acrylic acid)s to sections of gastric mucosa from the pyloric region of pigs stomach were evaluated using 'static' and 'dynamic flow' test systems. Dispersions (3%) of 'low', 'high' and 'ultra high' (cross-linked) polymers were seen to adhere to porcine pyloric mucosa after exposure and rinsing in the 'static' system. The high molecular weight polymer showed the greatest retention in the 'dynamic' test system when washing continuously with simulated gastric acid. Changing the pH of the dispersions from 4.3 to 6.2 had little effect on polymer retention. It was concluded that polymers that were sufficiently mobile in solution to spread on, and interact with, the mucosal surface, but had a sufficiently high molecular weight to form viscous solutions and/or bioadhere to the mucosa, may be retained on the mucosal surface for the longest periods.

AB - Polymers that bind from solution onto gastric mucosae can be used as a means of facilitating localised drug delivery, or act as therapeutic agents in their own right (e.g. by forming a protective layer or by inhibiting enzymes). Previous workers have used semi-quantitative methods to identify the ability of commercially available poly(acrylic acid)s to bind to gastric mucosa. In this study, the binding and retention of labelled poly(acrylic acid)s to sections of gastric mucosa from the pyloric region of pigs stomach were evaluated using 'static' and 'dynamic flow' test systems. Dispersions (3%) of 'low', 'high' and 'ultra high' (cross-linked) polymers were seen to adhere to porcine pyloric mucosa after exposure and rinsing in the 'static' system. The high molecular weight polymer showed the greatest retention in the 'dynamic' test system when washing continuously with simulated gastric acid. Changing the pH of the dispersions from 4.3 to 6.2 had little effect on polymer retention. It was concluded that polymers that were sufficiently mobile in solution to spread on, and interact with, the mucosal surface, but had a sufficiently high molecular weight to form viscous solutions and/or bioadhere to the mucosa, may be retained on the mucosal surface for the longest periods.

KW - Bioadhesion

KW - Gastric mucosa

KW - Mucoadhesion

KW - Poly(acrylic acid)s

UR - http://www.scopus.com/inward/record.url?scp=0037006920&partnerID=8YFLogxK

U2 - 10.1016/S0378-5173(02)00014-5

DO - 10.1016/S0378-5173(02)00014-5

M3 - Article

C2 - 11891073

AN - SCOPUS:0037006920

VL - 236

SP - 87

EP - 96

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 11419752