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An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus

Research output: Contribution to journalArticle

Standard

An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus. / Smart, John D.; Dunkley, Sian; Tsibouklis, John; Young, Simon.

In: International Journal of Pharmaceutics, Vol. 447, No. 1-2, 15.04.2013, p. 199-203.

Research output: Contribution to journalArticle

Harvard

Smart, JD, Dunkley, S, Tsibouklis, J & Young, S 2013, 'An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus', International Journal of Pharmaceutics, vol. 447, no. 1-2, pp. 199-203. https://doi.org/10.1016/j.ijpharm.2013.02.017

APA

Smart, J. D., Dunkley, S., Tsibouklis, J., & Young, S. (2013). An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus. International Journal of Pharmaceutics, 447(1-2), 199-203. https://doi.org/10.1016/j.ijpharm.2013.02.017

Vancouver

Author

Smart, John D. ; Dunkley, Sian ; Tsibouklis, John ; Young, Simon. / An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus. In: International Journal of Pharmaceutics. 2013 ; Vol. 447, No. 1-2. pp. 199-203.

Bibtex

@article{194ee3217c32441daff0a8946ba71eaa,
title = "An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus",
abstract = "Adhesion of solid oral dosage forms to the oesophagus can be a disadvantage when delivering drugs that may cause oesophageal damage, or can be an advantage when developing localised therapies for this region. In this study, apparatus to investigate coatings that may influence oesophageal retention was developed and evaluated. The apparatus incorporated a section of porcine oesophageal mucosa held flat by the application of a gentle vacuum and kept moist by the application of a simulated saliva solution. The resistance to the application of more physiologically relevant shear stresses was evaluated. Using a range of materials it was found that differences in oesophageal adhesion could be identified. Materials like sodium alginate were highly adhesive and had a tendency to re-adhere while paraffin waxes showed no adhesion. The rapid loss of the polymer coat from the surface for water swellable materials was identified as an issue.",
author = "Smart, {John D.} and Sian Dunkley and John Tsibouklis and Simon Young",
year = "2013",
month = "4",
day = "15",
doi = "10.1016/j.ijpharm.2013.02.017",
language = "English",
volume = "447",
pages = "199--203",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus

AU - Smart, John D.

AU - Dunkley, Sian

AU - Tsibouklis, John

AU - Young, Simon

PY - 2013/4/15

Y1 - 2013/4/15

N2 - Adhesion of solid oral dosage forms to the oesophagus can be a disadvantage when delivering drugs that may cause oesophageal damage, or can be an advantage when developing localised therapies for this region. In this study, apparatus to investigate coatings that may influence oesophageal retention was developed and evaluated. The apparatus incorporated a section of porcine oesophageal mucosa held flat by the application of a gentle vacuum and kept moist by the application of a simulated saliva solution. The resistance to the application of more physiologically relevant shear stresses was evaluated. Using a range of materials it was found that differences in oesophageal adhesion could be identified. Materials like sodium alginate were highly adhesive and had a tendency to re-adhere while paraffin waxes showed no adhesion. The rapid loss of the polymer coat from the surface for water swellable materials was identified as an issue.

AB - Adhesion of solid oral dosage forms to the oesophagus can be a disadvantage when delivering drugs that may cause oesophageal damage, or can be an advantage when developing localised therapies for this region. In this study, apparatus to investigate coatings that may influence oesophageal retention was developed and evaluated. The apparatus incorporated a section of porcine oesophageal mucosa held flat by the application of a gentle vacuum and kept moist by the application of a simulated saliva solution. The resistance to the application of more physiologically relevant shear stresses was evaluated. Using a range of materials it was found that differences in oesophageal adhesion could be identified. Materials like sodium alginate were highly adhesive and had a tendency to re-adhere while paraffin waxes showed no adhesion. The rapid loss of the polymer coat from the surface for water swellable materials was identified as an issue.

U2 - 10.1016/j.ijpharm.2013.02.017

DO - 10.1016/j.ijpharm.2013.02.017

M3 - Article

VL - 447

SP - 199

EP - 203

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 1782038