Animal models of major depressive disorder and the implications for drug discovery and development
Research output: Contribution to journal › Review article › peer-review
Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the study of depression. Novel approaches continuously emerge that may help untangle the disorder heterogeneity and unclear categories of disease classification systems. Some of these approaches include widening the spectrum of model species used for translational research, using a broader range of test paradigms, exploring new pathogenic pathways and biomarkers, and focusing more closely on processes beyond neural cells (e.g. glial, inflammatory and metabolic deficits).
Expert opinion: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling. Conceptually novel approaches based on the endophenotype paradigm, cross-species trait genetics and ‘domain interplay concept’, as well as using a wider spectrum of model organisms and target systems will enhance experimental modeling of depression and antidepressant drug discovery.
|Number of pages||14|
|Journal||Expert Opinion on Drug Discovery|
|Early online date||22 Feb 2019|
|Publication status||Published - 3 Apr 2019|
- Animal models of major depressive disorder
Rights statement: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Drug Discovery on 22/02/2019, available online: http://www.tandfonline.com/10.1080/17460441.2019.1575360.
Accepted author manuscript (Post-print), 815 KB, PDF document