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Animal models of major depressive disorder and the implications for drug discovery and development

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Animal models of major depressive disorder and the implications for drug discovery and development. / Demin, Konstantin A.; Sysoev, Maxim; Chernysh, Maria V.; Savva, Anna K.; Koshiba, Mamiko; Wappler-Guzzetta, Edina A.; Song, Cai; De Abreu, Murilo S.; Leonard, Brian; Parker, Matthew O.; Harvey, Brian H.; Tian, Li; Vasar, Eero; Strekalova, Tatyana; Amstislavskaya, Tamara G.; Volgin, Andrey D.; Alpyshov, Erik T.; Wang, Dongmei; Kalueff, Allan V.

In: Expert Opinion on Drug Discovery, Vol. 14, No. 4, 03.04.2019, p. 365-378.

Research output: Contribution to journalReview articlepeer-review

Harvard

Demin, KA, Sysoev, M, Chernysh, MV, Savva, AK, Koshiba, M, Wappler-Guzzetta, EA, Song, C, De Abreu, MS, Leonard, B, Parker, MO, Harvey, BH, Tian, L, Vasar, E, Strekalova, T, Amstislavskaya, TG, Volgin, AD, Alpyshov, ET, Wang, D & Kalueff, AV 2019, 'Animal models of major depressive disorder and the implications for drug discovery and development', Expert Opinion on Drug Discovery, vol. 14, no. 4, pp. 365-378. https://doi.org/10.1080/17460441.2019.1575360

APA

Demin, K. A., Sysoev, M., Chernysh, M. V., Savva, A. K., Koshiba, M., Wappler-Guzzetta, E. A., Song, C., De Abreu, M. S., Leonard, B., Parker, M. O., Harvey, B. H., Tian, L., Vasar, E., Strekalova, T., Amstislavskaya, T. G., Volgin, A. D., Alpyshov, E. T., Wang, D., & Kalueff, A. V. (2019). Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opinion on Drug Discovery, 14(4), 365-378. https://doi.org/10.1080/17460441.2019.1575360

Vancouver

Demin KA, Sysoev M, Chernysh MV, Savva AK, Koshiba M, Wappler-Guzzetta EA et al. Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opinion on Drug Discovery. 2019 Apr 3;14(4):365-378. https://doi.org/10.1080/17460441.2019.1575360

Author

Demin, Konstantin A. ; Sysoev, Maxim ; Chernysh, Maria V. ; Savva, Anna K. ; Koshiba, Mamiko ; Wappler-Guzzetta, Edina A. ; Song, Cai ; De Abreu, Murilo S. ; Leonard, Brian ; Parker, Matthew O. ; Harvey, Brian H. ; Tian, Li ; Vasar, Eero ; Strekalova, Tatyana ; Amstislavskaya, Tamara G. ; Volgin, Andrey D. ; Alpyshov, Erik T. ; Wang, Dongmei ; Kalueff, Allan V. / Animal models of major depressive disorder and the implications for drug discovery and development. In: Expert Opinion on Drug Discovery. 2019 ; Vol. 14, No. 4. pp. 365-378.

Bibtex

@article{430c052a4757487dac0e69063d75d1da,
title = "Animal models of major depressive disorder and the implications for drug discovery and development",
abstract = "Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and recurrent, necessitating the development of novel therapies, models and concepts in this field.Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the study of depression. Novel approaches continuously emerge that may help untangle the disorder heterogeneity and unclear categories of disease classification systems. Some of these approaches include widening the spectrum of model species used for translational research, using a broader range of test paradigms, exploring new pathogenic pathways and biomarkers, and focusing more closely on processes beyond neural cells (e.g. glial, inflammatory and metabolic deficits).Expert opinion: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling. Conceptually novel approaches based on the endophenotype paradigm, cross-species trait genetics and {\textquoteleft}domain interplay concept{\textquoteright}, as well as using a wider spectrum of model organisms and target systems will enhance experimental modeling of depression and antidepressant drug discovery.",
keywords = "depression, major depressive disorder, animal modeling, pathogenesis, endophenotype",
author = "Demin, {Konstantin A.} and Maxim Sysoev and Chernysh, {Maria V.} and Savva, {Anna K.} and Mamiko Koshiba and Wappler-Guzzetta, {Edina A.} and Cai Song and {De Abreu}, {Murilo S.} and Brian Leonard and Parker, {Matthew O.} and Harvey, {Brian H.} and Li Tian and Eero Vasar and Tatyana Strekalova and Amstislavskaya, {Tamara G.} and Volgin, {Andrey D.} and Alpyshov, {Erik T.} and Dongmei Wang and Kalueff, {Allan V.}",
year = "2019",
month = apr,
day = "3",
doi = "10.1080/17460441.2019.1575360",
language = "English",
volume = "14",
pages = "365--378",
journal = "Expert Opinion on Drug Discovery",
issn = "1746-0441",
publisher = "Informa Healthcare",
number = "4",

}

RIS

TY - JOUR

T1 - Animal models of major depressive disorder and the implications for drug discovery and development

AU - Demin, Konstantin A.

AU - Sysoev, Maxim

AU - Chernysh, Maria V.

AU - Savva, Anna K.

AU - Koshiba, Mamiko

AU - Wappler-Guzzetta, Edina A.

AU - Song, Cai

AU - De Abreu, Murilo S.

AU - Leonard, Brian

AU - Parker, Matthew O.

AU - Harvey, Brian H.

AU - Tian, Li

AU - Vasar, Eero

AU - Strekalova, Tatyana

AU - Amstislavskaya, Tamara G.

AU - Volgin, Andrey D.

AU - Alpyshov, Erik T.

AU - Wang, Dongmei

AU - Kalueff, Allan V.

PY - 2019/4/3

Y1 - 2019/4/3

N2 - Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and recurrent, necessitating the development of novel therapies, models and concepts in this field.Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the study of depression. Novel approaches continuously emerge that may help untangle the disorder heterogeneity and unclear categories of disease classification systems. Some of these approaches include widening the spectrum of model species used for translational research, using a broader range of test paradigms, exploring new pathogenic pathways and biomarkers, and focusing more closely on processes beyond neural cells (e.g. glial, inflammatory and metabolic deficits).Expert opinion: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling. Conceptually novel approaches based on the endophenotype paradigm, cross-species trait genetics and ‘domain interplay concept’, as well as using a wider spectrum of model organisms and target systems will enhance experimental modeling of depression and antidepressant drug discovery.

AB - Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and recurrent, necessitating the development of novel therapies, models and concepts in this field.Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the study of depression. Novel approaches continuously emerge that may help untangle the disorder heterogeneity and unclear categories of disease classification systems. Some of these approaches include widening the spectrum of model species used for translational research, using a broader range of test paradigms, exploring new pathogenic pathways and biomarkers, and focusing more closely on processes beyond neural cells (e.g. glial, inflammatory and metabolic deficits).Expert opinion: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling. Conceptually novel approaches based on the endophenotype paradigm, cross-species trait genetics and ‘domain interplay concept’, as well as using a wider spectrum of model organisms and target systems will enhance experimental modeling of depression and antidepressant drug discovery.

KW - depression

KW - major depressive disorder

KW - animal modeling

KW - pathogenesis

KW - endophenotype

U2 - 10.1080/17460441.2019.1575360

DO - 10.1080/17460441.2019.1575360

M3 - Review article

VL - 14

SP - 365

EP - 378

JO - Expert Opinion on Drug Discovery

JF - Expert Opinion on Drug Discovery

SN - 1746-0441

IS - 4

ER -

ID: 13623059