Skip to content
Back to outputs

Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment

Research output: Contribution to journalArticlepeer-review

Standard

Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. / Lewinsohn, A. D.; Anssari-Benam, Afshin; Lee, D. A. ; Taylor, P. M.; Chester, A. H. ; Yacoub , M. H.; Screen, H. R. C. .

In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 225, No. 8, 01.08.2011, p. 821-830.

Research output: Contribution to journalArticlepeer-review

Harvard

Lewinsohn, AD, Anssari-Benam, A, Lee, DA, Taylor, PM, Chester, AH, Yacoub , MH & Screen, HRC 2011, 'Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment', Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, vol. 225, no. 8, pp. 821-830. https://doi.org/10.1177/0954411911406340

APA

Lewinsohn, A. D., Anssari-Benam, A., Lee, D. A., Taylor, P. M., Chester, A. H., Yacoub , M. H., & Screen, H. R. C. (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 225(8), 821-830. https://doi.org/10.1177/0954411911406340

Vancouver

Lewinsohn AD, Anssari-Benam A, Lee DA, Taylor PM, Chester AH, Yacoub MH et al. Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2011 Aug 1;225(8):821-830. https://doi.org/10.1177/0954411911406340

Author

Lewinsohn, A. D. ; Anssari-Benam, Afshin ; Lee, D. A. ; Taylor, P. M. ; Chester, A. H. ; Yacoub , M. H. ; Screen, H. R. C. . / Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2011 ; Vol. 225, No. 8. pp. 821-830.

Bibtex

@article{14383dd8fdaa4d9a8a49719ef906fcf9,
title = "Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment",
abstract = "Aortic valve interstitial cells are responsible for maintaining the valve in response to their local mechanical environment. However, the complex organization of the extracellular matrix means cell strains cannot be directly derived from gross strains, and knowledge of tissue structure-function correlations is fundamental towards understanding mechanotransduction. This study investigates strain transfer through the valve, hypothesizing that organization of the valve matrix leads to non-homogenous local strains. Radial and circumferential samples were cut from aortic valve leaflets and subjected to quasi-static mechanical characterization. Further samples were imaged using confocal microscopy, to determine local strains in the matrix. Mechanical data demonstrated that the valve was significantly stronger and stiffer when loaded circumferentially, comparable with previous studies. Micromechanical studies demonstrated that strain transfer through the matrix is anisotropic and indirect, with local strains consistently smaller than applied strains in both orientations. Under radial loading, strains were transferred linearly to cells. However, under circumferential loading, strains were only one-third of applied values, with a less direct relationship between applied and local strains. This may result from matrix reorganization, and be important for preventing cellular damage during normal valve function. These findings should be taken into account when investigating interstitial cell behaviours, such as cell metabolism and mechanotransduction.",
author = "Lewinsohn, {A. D.} and Afshin Anssari-Benam and Lee, {D. A.} and Taylor, {P. M.} and Chester, {A. H.} and Yacoub, {M. H.} and Screen, {H. R. C.}",
note = "Publisher by SAGE",
year = "2011",
month = aug,
day = "1",
doi = "10.1177/0954411911406340",
language = "English",
volume = "225",
pages = "821--830",
journal = "Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine",
issn = "0954-4119",
publisher = "SAGE Publications Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment

AU - Lewinsohn, A. D.

AU - Anssari-Benam, Afshin

AU - Lee, D. A.

AU - Taylor, P. M.

AU - Chester, A. H.

AU - Yacoub , M. H.

AU - Screen, H. R. C.

N1 - Publisher by SAGE

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Aortic valve interstitial cells are responsible for maintaining the valve in response to their local mechanical environment. However, the complex organization of the extracellular matrix means cell strains cannot be directly derived from gross strains, and knowledge of tissue structure-function correlations is fundamental towards understanding mechanotransduction. This study investigates strain transfer through the valve, hypothesizing that organization of the valve matrix leads to non-homogenous local strains. Radial and circumferential samples were cut from aortic valve leaflets and subjected to quasi-static mechanical characterization. Further samples were imaged using confocal microscopy, to determine local strains in the matrix. Mechanical data demonstrated that the valve was significantly stronger and stiffer when loaded circumferentially, comparable with previous studies. Micromechanical studies demonstrated that strain transfer through the matrix is anisotropic and indirect, with local strains consistently smaller than applied strains in both orientations. Under radial loading, strains were transferred linearly to cells. However, under circumferential loading, strains were only one-third of applied values, with a less direct relationship between applied and local strains. This may result from matrix reorganization, and be important for preventing cellular damage during normal valve function. These findings should be taken into account when investigating interstitial cell behaviours, such as cell metabolism and mechanotransduction.

AB - Aortic valve interstitial cells are responsible for maintaining the valve in response to their local mechanical environment. However, the complex organization of the extracellular matrix means cell strains cannot be directly derived from gross strains, and knowledge of tissue structure-function correlations is fundamental towards understanding mechanotransduction. This study investigates strain transfer through the valve, hypothesizing that organization of the valve matrix leads to non-homogenous local strains. Radial and circumferential samples were cut from aortic valve leaflets and subjected to quasi-static mechanical characterization. Further samples were imaged using confocal microscopy, to determine local strains in the matrix. Mechanical data demonstrated that the valve was significantly stronger and stiffer when loaded circumferentially, comparable with previous studies. Micromechanical studies demonstrated that strain transfer through the matrix is anisotropic and indirect, with local strains consistently smaller than applied strains in both orientations. Under radial loading, strains were transferred linearly to cells. However, under circumferential loading, strains were only one-third of applied values, with a less direct relationship between applied and local strains. This may result from matrix reorganization, and be important for preventing cellular damage during normal valve function. These findings should be taken into account when investigating interstitial cell behaviours, such as cell metabolism and mechanotransduction.

U2 - 10.1177/0954411911406340

DO - 10.1177/0954411911406340

M3 - Article

VL - 225

SP - 821

EP - 830

JO - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

JF - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

SN - 0954-4119

IS - 8

ER -

ID: 917117