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Antioxidant effects of Angiotensin converting enzyme (ACE) inhibitors: Free radical and oxidant scavenging are sulfhydryl dependent, but lipid peroxidation is inhibited by both sulfhydryl and nonsulfhydryl containing ACE inhibitors

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With an assay that generates free radicals (FR) through photooxidation of dianisidine sensitized by riboflavin, 4 × 10−5M captopril, epicaptopril (SQ 14,534, captopril's stereoisomer), zofenopril, and fentiapril [all sulfhydryl (-SH)-containing angiotensin-converting enzyme (ACE) inhibitors] were shown effective scavengers of nonsuperoxide free radicals whereas non-SH ACE inhibitors were not. Captopril was a more effective FR scavenger at pH 5.0 than at pH 7.5. Captopril (2 × 10−5M) also scavenged the other toxic oxygen species hydrogen peroxide and singlet oxygen and inhibited microsomal lipid peroxidation. Finally, captopril reduced the amount of superoxide anion-radical detected after neutrophils in whole blood were activated with zymosan, probably by inhibiting leukocyte superoxide production.
Original languageEnglish
Pages330-340
Volume19
Issue number3
JournalJournal of Cardiovascular Pharmacology
Publication statusPublished - 1992

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