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Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

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Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.
Original languageEnglish
Pages (from-to)4864-4871
Number of pages8
JournalJournal of Materials Chemistry
Volume18
Issue number40
DOIs
Publication statusPublished - 2008

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