This paper outlines potential opportunities for Africa’s Large Marine Ecosystems (LMEs) devel-opment driven by blue economy from key strategic sectors including: Coastal and Marine Tour-ism; Climate Resilience; Environment; Blue Carbon and Ecosystem Services and Infrastructure. The sectoral approach is key to economic development in Africa with potential for income gener-ation, employment creation and poverty reduction, as well as creating blue and green carbon sinks to address climate change problem and environmental management in African LMEs. The sectors establish linkages to countries’ established Nationally Determined Contributions (NDCs) under the 2015 Paris Agreement on Climate Change making it possible to promote Integrated Approach at national, regional and continental sustainable development in Africa. The approach is complemented by the utilizing desk-top literature review and secondary data source on LMEs in Africa for blue economy. This approach is supplemented with professional experts’ views and opinions, and additional data gathered from field visits to 13 African countries in August 2019 and Nairobi, Kenya Africa Blue Economy Strategy Consultative Workshop in October 2019. The Blue Economy approach development in Africa will benefit both inland and coastal countries. It is recommended that a strong development of the continental tourism will boost the demand for tourism services and infrastructures. The development of eco-tourism will contribute to the con-servation of ecosystems and reduce the ecological footprint. Blue Carbon and Ecosystem Ser-vices offer an opportunity to develop coastal wetland projects to mitigating climate change. Coastal protection, biomass production and water purification are among the most important eco-system services delivered by African LMEs. Their current value is estimated to the average mon-etary value of carbon sequestration of about USD 130,000 per km2 of mangrove, salt marshes and sea grasses.