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Controlled release of 5-fluorouracil from microporous zeolites

Research output: Contribution to journalArticlepeer-review

  • Marios Spanakis
  • Nikolaos Bouropoulos
  • Dimitrios Theodoropoulos
  • Lamprini Sygellou
  • Sinead Ewart
  • Anastasia Maria Moschovi
  • Angeliki Siokou
  • Ioannis Niopas
  • Kyriakos Kachrimanis
  • Vladimiros Nikolakis
  • Professor Paul Cox
  • Ioannis S. Vizirianakis
  • Dimitrios G. Fatouros
Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.
Original languageEnglish
Pages (from-to)197-205
JournalNanomedicine: Nanotechnology, Biology and Medicine
Volume10
Issue number1
Early online date3 Aug 2013
DOIs
Publication statusPublished - Jan 2014

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  • 5fu

    Accepted author manuscript (Post-print), 1.2 MB, PDF document

    Licence: CC BY-NC-ND

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