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Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts

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Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts. / Myers, Fiona; Francis-Lang, H.; Newbury, S.

In: Mechanisms of Development, Vol. 51, No. 2-3, 1995, p. 217-226.

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Myers, Fiona ; Francis-Lang, H. ; Newbury, S. / Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts. In: Mechanisms of Development. 1995 ; Vol. 51, No. 2-3. pp. 217-226.

Bibtex

@article{19f763f8904845829d7a72c65e319040,
title = "Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts",
abstract = "In Drosophila, maternalstring mRNAs are stable for the first few hours of development, but undergo specific timed degradation at the cellularisation stage. To determine whether the proteins that control this degradation are maternally or zygotically transcribed, we have used in situ hybridisation to determine the fate of maternal string transcripts in mutant embryos which lack individual chromosome arms. Our data indicate that maternal string mRNA persists for the normal period in all these mutants. Using α-amanitin to inhibit zygotic transcription we have shown that degradation of maternal mRNA is unaffected. Therefore, the proteins required to activate the degradation of string mRNA are encoded on a maternally contributed mRNA. We discuss possible models to explain the degradation pathway.",
author = "Fiona Myers and H. Francis-Lang and S. Newbury",
year = "1995",
doi = "10.1016/0925-4773(95)00366-5",
language = "English",
volume = "51",
pages = "217--226",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

RIS

TY - JOUR

T1 - Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts

AU - Myers, Fiona

AU - Francis-Lang, H.

AU - Newbury, S.

PY - 1995

Y1 - 1995

N2 - In Drosophila, maternalstring mRNAs are stable for the first few hours of development, but undergo specific timed degradation at the cellularisation stage. To determine whether the proteins that control this degradation are maternally or zygotically transcribed, we have used in situ hybridisation to determine the fate of maternal string transcripts in mutant embryos which lack individual chromosome arms. Our data indicate that maternal string mRNA persists for the normal period in all these mutants. Using α-amanitin to inhibit zygotic transcription we have shown that degradation of maternal mRNA is unaffected. Therefore, the proteins required to activate the degradation of string mRNA are encoded on a maternally contributed mRNA. We discuss possible models to explain the degradation pathway.

AB - In Drosophila, maternalstring mRNAs are stable for the first few hours of development, but undergo specific timed degradation at the cellularisation stage. To determine whether the proteins that control this degradation are maternally or zygotically transcribed, we have used in situ hybridisation to determine the fate of maternal string transcripts in mutant embryos which lack individual chromosome arms. Our data indicate that maternal string mRNA persists for the normal period in all these mutants. Using α-amanitin to inhibit zygotic transcription we have shown that degradation of maternal mRNA is unaffected. Therefore, the proteins required to activate the degradation of string mRNA are encoded on a maternally contributed mRNA. We discuss possible models to explain the degradation pathway.

U2 - 10.1016/0925-4773(95)00366-5

DO - 10.1016/0925-4773(95)00366-5

M3 - Article

VL - 51

SP - 217

EP - 226

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 2-3

ER -

ID: 155851