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Development of the skeletal system

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The analysis of the development of the skeletal system has been greatly facilitated by the availability of a large number of mouse mutants with skeletal defects. Whereas for many of these mutants a description of the main phenotypic abnormalities is known, molecular insight into the ontogeny of the skeletal system is limited. One of the few skeletal mutants for which the molecular basis is known is undulated. These mice have a defect in the differentiation of the sclerotomeand Pax-1, a mouse paired-box containing gene, has been identified as a candidate gene for this mutation. A molecular analysis of three independent undulated allelesrevealed that in each case the Pax-1 gene is affected. One of the alleles could be classified as a null allele, in which the Pax-1 gene is deleted. A phenotypic analysis shows that Pax-1 is required for proper differentiation of intervertebral discs and vertebral bodies
Original languageEnglish
Title of host publicationCIBA foundation symposium. Vol. 165, Postimplantation development in the mouse
EditorsDerek J. Chadwick, Joan Marsh
Place of PublicationChichester
ISBN (Print)9780471933847
Publication statusPublished - 1992
Externally publishedYes

Publication series

NameNovartis Foundation Symposia
ISSN (Print)1935-4657

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