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"Dressed-up" naked plasmids: emerging vectors for non-viral gene therapy

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The non-viral vectors and targeting methods offer some specific advantages. These include better safety profiles (lower toxicity and non-infectious properties) and the capacity to transfer large genes and low production costs. The clinical usefulness of non-viral methods has been hindered by their relatively low gene delivery and transgene expression efficiencies. However, recent problems in clinical trials using viral vectors renewed interest in non-viral technologies, particularly that the properties of non-viral vectors make them appear closer to the traditional pharmaceutics.
Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalDiscovery Medicine
Issue number35
Publication statusPublished - 2006

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