Skip to content

"Dressed-up" naked plasmids: emerging vectors for non-viral gene therapy

Research output: Contribution to journalArticlepeer-review

The non-viral vectors and targeting methods offer some specific advantages. These include better safety profiles (lower toxicity and non-infectious properties) and the capacity to transfer large genes and low production costs. The clinical usefulness of non-viral methods has been hindered by their relatively low gene delivery and transgene expression efficiencies. However, recent problems in clinical trials using viral vectors renewed interest in non-viral technologies, particularly that the properties of non-viral vectors make them appear closer to the traditional pharmaceutics.
Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalDiscovery Medicine
Volume6
Issue number35
Publication statusPublished - 2006

Related information

Relations Get citation (various referencing formats)

ID: 132230