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Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum

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Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum. / Riley, Kerry; Gledhill, S.; Schubert, Frank.

In: International Journal of Developmental Biology, Vol. 54, No. 4, 2010, p. 743-753.

Research output: Contribution to journalArticle

Harvard

Riley, K, Gledhill, S & Schubert, F 2010, 'Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum', International Journal of Developmental Biology, vol. 54, no. 4, pp. 743-753. https://doi.org/10.1387/ijdb.082803kr

APA

Riley, K., Gledhill, S., & Schubert, F. (2010). Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum. International Journal of Developmental Biology, 54(4), 743-753. https://doi.org/10.1387/ijdb.082803kr

Vancouver

Author

Riley, Kerry ; Gledhill, S. ; Schubert, Frank. / Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum. In: International Journal of Developmental Biology. 2010 ; Vol. 54, No. 4. pp. 743-753.

Bibtex

@article{54bc4a1d705e4166882265cfa355993d,
title = "Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum",
abstract = "Early axon tracts in the developing vertebrate brain are established along precise paths. Yet, little is known about axon guidance processes at early stages of rostral brain development. Using whole mount in situ hybridisation in combination with immunohistochemistry, we have analysed the expression patterns of Slits, Netrins, Semaphorins and the respective receptors during the formation of the early axon scaffold, particularly focusing on the pretectal-mesencephalic boundary. Many of these guidance molecules are expressed in close correlation with the growing tracts, and the nuclei of the corresponding neurons often express the respective receptors. The expression patterns of Slits and Netrins implicate them with the positioning of the longitudinal tracts along the dorsoventral axis, while Semaphorins could provide guidance at specific choice points. Our study provides a catalogue of gene expression for future studies on axon guidance mechanisms in the early brain.",
author = "Kerry Riley and S. Gledhill and Frank Schubert",
year = "2010",
doi = "10.1387/ijdb.082803kr",
language = "English",
volume = "54",
pages = "743--753",
journal = "International Journal of Developmental Biology",
issn = "0214-6282",
publisher = "University of the Basque Country Press",
number = "4",

}

RIS

TY - JOUR

T1 - Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum

AU - Riley, Kerry

AU - Gledhill, S.

AU - Schubert, Frank

PY - 2010

Y1 - 2010

N2 - Early axon tracts in the developing vertebrate brain are established along precise paths. Yet, little is known about axon guidance processes at early stages of rostral brain development. Using whole mount in situ hybridisation in combination with immunohistochemistry, we have analysed the expression patterns of Slits, Netrins, Semaphorins and the respective receptors during the formation of the early axon scaffold, particularly focusing on the pretectal-mesencephalic boundary. Many of these guidance molecules are expressed in close correlation with the growing tracts, and the nuclei of the corresponding neurons often express the respective receptors. The expression patterns of Slits and Netrins implicate them with the positioning of the longitudinal tracts along the dorsoventral axis, while Semaphorins could provide guidance at specific choice points. Our study provides a catalogue of gene expression for future studies on axon guidance mechanisms in the early brain.

AB - Early axon tracts in the developing vertebrate brain are established along precise paths. Yet, little is known about axon guidance processes at early stages of rostral brain development. Using whole mount in situ hybridisation in combination with immunohistochemistry, we have analysed the expression patterns of Slits, Netrins, Semaphorins and the respective receptors during the formation of the early axon scaffold, particularly focusing on the pretectal-mesencephalic boundary. Many of these guidance molecules are expressed in close correlation with the growing tracts, and the nuclei of the corresponding neurons often express the respective receptors. The expression patterns of Slits and Netrins implicate them with the positioning of the longitudinal tracts along the dorsoventral axis, while Semaphorins could provide guidance at specific choice points. Our study provides a catalogue of gene expression for future studies on axon guidance mechanisms in the early brain.

U2 - 10.1387/ijdb.082803kr

DO - 10.1387/ijdb.082803kr

M3 - Article

VL - 54

SP - 743

EP - 753

JO - International Journal of Developmental Biology

JF - International Journal of Developmental Biology

SN - 0214-6282

IS - 4

ER -

ID: 36546