Effects of normobaric hypoxia on oxygen saturation variability
Research output: Contribution to journal › Article › peer-review
Materials and Methods: Twelve healthy males (mean [standard deviation] age 22  years) were exposed to four simulated environments (fraction of inspired oxygen [FIO2]: 0.12, 0.145, 0.17, and 0.21) for 45 minutes, in a balanced crossover design.
Results: Sample entropy, a tool that quantifies the irregularity of pulse oximetry fluctuations, was used as a measure of SpO2 variability. SpO2 entropy increased as the FIO2 decreased, and there was a strong significant negative correlation between mean SpO2 and its entropy during hypoxic exposure (r = −0.841 to −0.896, p < 0.001). In addition, SpO2 sample entropy, but not mean SpO2, was correlated (r = 0.630–0.760, p < 0.05) with dyspnea in FIO2 0.17, 0.145, and 0.12 and importantly, SpO2 sample entropy at FIO2 0.17 was correlated with dyspnea at FIO2 0.145 (r = 0.811, p < 0.01).
Conclusions: These findings suggest that SpO2 variability analysis may have the potential to be used in a clinical setting as a noninvasive measure to identify the negative sequelae of hypoxemia.
|Journal||High Altitude Medicine and Biology|
|Early online date||18 Feb 2020|
|Publication status||Early online - 18 Feb 2020|
- Effects of Normobaric Hypoxia
Rights statement: Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/ham.2019.0092.
Accepted author manuscript (Post-print), 564 KB, PDF document
Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 18/02/21