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Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach

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Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach. / Anssari-Benam, Afshin; Barber, Asa Hilton; Bucchi, Andrea.

In: Journal of Materials Science: Materials in Medicine, Vol. 27, No. 42, 02.2016, p. 1-11.

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Anssari-Benam, Afshin ; Barber, Asa Hilton ; Bucchi, Andrea. / Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach. In: Journal of Materials Science: Materials in Medicine. 2016 ; Vol. 27, No. 42. pp. 1-11.

Bibtex

@article{258d12f497c0476c9f159ff656d9f780,
title = "Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach",
abstract = "A matrix-fibril shear stress transfer approach is devised and developed in this paper to analyse the primary biomechanical factors which initiate the structural degeneration of the bioprosthetic heart valves (BHVs). Using this approach, the critical length of the collagen fibrils lc and the interface shear acting on the fibrils in both BHV and natural aortic valve (AV) tissues under physiological loading conditions are calculated and presented. It is shown that the required critical fibril length to provide effective reinforcement to the natural AV and the BHV tissue is lc = 25.36 µm and lc = 66.81 µm, respectively. Furthermore, the magnitude of the required shear force acting on fibril interface to break a cross-linked fibril in the BHV tissue is shown to be 38 µN, while the required interfacial force to break the bonds between the fibril and the surrounding extracellular matrix is 31 µN. Direct correlations are underpinned between these values and the ultimate failure strength and the failure mode of the BHV tissue compared with the natural AV, and are verified against the existing experimental data. The analyses presented in this paper explain the role of fibril interface shear and critical length in regulating the biomechanics of the structural failure of the BHVs, for the first time. This insight facilitates further understanding into the underlying causes of the structural degeneration of the BHVs in vivo.",
keywords = "Bioproethetic heart valve, Aortic Valve, Fibre-reinforced composite materials, Structural failure, Critical length, Fibril interface shear",
author = "Afshin Anssari-Benam and Barber, {Asa Hilton} and Andrea Bucchi",
note = "Published online - 29/12/2015",
year = "2016",
month = feb,
doi = "10.1007/s10856-015-5657-2",
language = "English",
volume = "27",
pages = "1--11",
journal = "Journal of Materials Science: Materials in Medicine",
issn = "0957-4530",
publisher = "Springer Netherlands",
number = "42",

}

RIS

TY - JOUR

T1 - Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach

AU - Anssari-Benam, Afshin

AU - Barber, Asa Hilton

AU - Bucchi, Andrea

N1 - Published online - 29/12/2015

PY - 2016/2

Y1 - 2016/2

N2 - A matrix-fibril shear stress transfer approach is devised and developed in this paper to analyse the primary biomechanical factors which initiate the structural degeneration of the bioprosthetic heart valves (BHVs). Using this approach, the critical length of the collagen fibrils lc and the interface shear acting on the fibrils in both BHV and natural aortic valve (AV) tissues under physiological loading conditions are calculated and presented. It is shown that the required critical fibril length to provide effective reinforcement to the natural AV and the BHV tissue is lc = 25.36 µm and lc = 66.81 µm, respectively. Furthermore, the magnitude of the required shear force acting on fibril interface to break a cross-linked fibril in the BHV tissue is shown to be 38 µN, while the required interfacial force to break the bonds between the fibril and the surrounding extracellular matrix is 31 µN. Direct correlations are underpinned between these values and the ultimate failure strength and the failure mode of the BHV tissue compared with the natural AV, and are verified against the existing experimental data. The analyses presented in this paper explain the role of fibril interface shear and critical length in regulating the biomechanics of the structural failure of the BHVs, for the first time. This insight facilitates further understanding into the underlying causes of the structural degeneration of the BHVs in vivo.

AB - A matrix-fibril shear stress transfer approach is devised and developed in this paper to analyse the primary biomechanical factors which initiate the structural degeneration of the bioprosthetic heart valves (BHVs). Using this approach, the critical length of the collagen fibrils lc and the interface shear acting on the fibrils in both BHV and natural aortic valve (AV) tissues under physiological loading conditions are calculated and presented. It is shown that the required critical fibril length to provide effective reinforcement to the natural AV and the BHV tissue is lc = 25.36 µm and lc = 66.81 µm, respectively. Furthermore, the magnitude of the required shear force acting on fibril interface to break a cross-linked fibril in the BHV tissue is shown to be 38 µN, while the required interfacial force to break the bonds between the fibril and the surrounding extracellular matrix is 31 µN. Direct correlations are underpinned between these values and the ultimate failure strength and the failure mode of the BHV tissue compared with the natural AV, and are verified against the existing experimental data. The analyses presented in this paper explain the role of fibril interface shear and critical length in regulating the biomechanics of the structural failure of the BHVs, for the first time. This insight facilitates further understanding into the underlying causes of the structural degeneration of the BHVs in vivo.

KW - Bioproethetic heart valve

KW - Aortic Valve

KW - Fibre-reinforced composite materials

KW - Structural failure

KW - Critical length

KW - Fibril interface shear

UR - http://link.springer.com/article/10.1007%2Fs10856-015-5657-2

U2 - 10.1007/s10856-015-5657-2

DO - 10.1007/s10856-015-5657-2

M3 - Article

VL - 27

SP - 1

EP - 11

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 42

ER -

ID: 3312971