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Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model

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Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model. / Clark, Jeffrey N.; Heyraud, Agathe; Tavana, Saman; Al-Jabri, Talal; Tallia, Francesca; Clark, Brett; Blunn, Gordon W.; Cobb, Justin P.; Hansen, Ulrich; Jones, Julian R.; Jeffers, Jonathan R. T.

In: Materials, Vol. 13, No. 18, 3911, 04.09.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Clark, JN, Heyraud, A, Tavana, S, Al-Jabri, T, Tallia, F, Clark, B, Blunn, GW, Cobb, JP, Hansen, U, Jones, JR & Jeffers, JRT 2020, 'Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model', Materials, vol. 13, no. 18, 3911. https://doi.org/10.3390/ma13183911

APA

Clark, J. N., Heyraud, A., Tavana, S., Al-Jabri, T., Tallia, F., Clark, B., Blunn, G. W., Cobb, J. P., Hansen, U., Jones, J. R., & Jeffers, J. R. T. (2020). Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model. Materials, 13(18), [3911]. https://doi.org/10.3390/ma13183911

Vancouver

Clark JN, Heyraud A, Tavana S, Al-Jabri T, Tallia F, Clark B et al. Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model. Materials. 2020 Sep 4;13(18). 3911. https://doi.org/10.3390/ma13183911

Author

Clark, Jeffrey N. ; Heyraud, Agathe ; Tavana, Saman ; Al-Jabri, Talal ; Tallia, Francesca ; Clark, Brett ; Blunn, Gordon W. ; Cobb, Justin P. ; Hansen, Ulrich ; Jones, Julian R. ; Jeffers, Jonathan R. T. / Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model. In: Materials. 2020 ; Vol. 13, No. 18.

Bibtex

@article{45bf531c7eaa4ec0937ad783612cefe7,
title = "Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model",
abstract = "Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.",
keywords = "RCUK, EPSRC, EP/N025059/1, EP/K027549/1",
author = "Clark, {Jeffrey N.} and Agathe Heyraud and Saman Tavana and Talal Al-Jabri and Francesca Tallia and Brett Clark and Blunn, {Gordon W.} and Cobb, {Justin P.} and Ulrich Hansen and Jones, {Julian R.} and Jeffers, {Jonathan R. T.}",
year = "2020",
month = sep,
day = "4",
doi = "10.3390/ma13183911",
language = "English",
volume = "13",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI AG",
number = "18",

}

RIS

TY - JOUR

T1 - Exploratory full-field mechanical analysis across the osteochondral tissue-biomaterial interface in an ovine model

AU - Clark, Jeffrey N.

AU - Heyraud, Agathe

AU - Tavana, Saman

AU - Al-Jabri, Talal

AU - Tallia, Francesca

AU - Clark, Brett

AU - Blunn, Gordon W.

AU - Cobb, Justin P.

AU - Hansen, Ulrich

AU - Jones, Julian R.

AU - Jeffers, Jonathan R. T.

PY - 2020/9/4

Y1 - 2020/9/4

N2 - Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.

AB - Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.

KW - RCUK

KW - EPSRC

KW - EP/N025059/1

KW - EP/K027549/1

U2 - 10.3390/ma13183911

DO - 10.3390/ma13183911

M3 - Article

VL - 13

JO - Materials

JF - Materials

SN - 1996-1944

IS - 18

M1 - 3911

ER -

ID: 22530498