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Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer

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Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer. / Smith, James; Olusanya, Temidayo; Owens, Ashleigh J. S.; Tseligka, Eirini D.; Vizirianakis, Ioannis S.; Tsibouklis, John.

In: Journal of Innovations in Pharmaceutical and Biological Sciences, Vol. 4, No. 4, 08.10.2017, p. 9-15.

Research output: Contribution to journalArticle

Harvard

Smith, J, Olusanya, T, Owens, AJS, Tseligka, ED, Vizirianakis, IS & Tsibouklis, J 2017, 'Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer', Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 4, no. 4, pp. 9-15. <http://www.jipbs.com/VolumeArticles/FullTextPDF/326_JIPBSV4I403N.pdf>

APA

Smith, J., Olusanya, T., Owens, A. J. S., Tseligka, E. D., Vizirianakis, I. S., & Tsibouklis, J. (2017). Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer. Journal of Innovations in Pharmaceutical and Biological Sciences, 4(4), 9-15. http://www.jipbs.com/VolumeArticles/FullTextPDF/326_JIPBSV4I403N.pdf

Vancouver

Smith J, Olusanya T, Owens AJS, Tseligka ED, Vizirianakis IS, Tsibouklis J. Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer. Journal of Innovations in Pharmaceutical and Biological Sciences. 2017 Oct 8;4(4):9-15.

Author

Smith, James ; Olusanya, Temidayo ; Owens, Ashleigh J. S. ; Tseligka, Eirini D. ; Vizirianakis, Ioannis S. ; Tsibouklis, John. / Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer. In: Journal of Innovations in Pharmaceutical and Biological Sciences. 2017 ; Vol. 4, No. 4. pp. 9-15.

Bibtex

@article{7d920f22e8e043c59e0c0ab24e40b124,
title = "Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer",
abstract = "Boron neutron capture therapy (BNCT) is a non-conventional type of radio-chemotherapy that has been used to target a number of cancers, although predominantly brain tumours (gliomas). We report the co-spray- drying of o-carborane, as a model BNCT agent, with poly(vinylpyrrolidone) (PVP), a water-soluble polymer, to produce microparticle powders of high boron-content for BNCT treatment of liver and lung cancers. The powders have been characterised using NMR, particle sizing, electron microscopy and cytotoxicity tests. 1H NMR indicated the high temperatures (180 °C) of the spray drying process did not degrade the PVP. Mean particle diameters (x90 ) were in the 2–10 µm range, with finer fractions being present (x10 ≅ 1–2 µm), and were therefore considered suitable size for delivery to the lungs. SEM imaging showed particles to be spherical, with dimples and cavities, caused by the spray drier nozzle characteristics, and similarly sized irregularly-shaped crystalline particles, thought to be o-carborane. Boron chemical mapping was attempted using EDS, although the low atomic weight of boron did not allow this to be possible. Cytotoxicity studies, using neoplastic (human glioblastoma U-87 MG) and non-neoplastic (human fetal lung fibroblast MRC-5) cells, revealed the PVP/o-carborane co-spray- dried particles to be non-toxic, as expected.",
keywords = "boron neutron capture therapy, BNCT, cancer, carborane, formulation, spray drying",
author = "James Smith and Temidayo Olusanya and Owens, {Ashleigh J. S.} and Tseligka, {Eirini D.} and Vizirianakis, {Ioannis S.} and John Tsibouklis",
year = "2017",
month = oct,
day = "8",
language = "English",
volume = "4",
pages = "9--15",
journal = "Journal of Innovations in Pharmaceutical and Biological Sciences",
issn = "2395-1095",
publisher = "Nocture Solutions",
number = "4",

}

RIS

TY - JOUR

T1 - Formulation and characterisation of spray-dried o-carborane/ poly(vinylpyrrolidone) for boron neutron capture therapy of liver and lung cancer

AU - Smith, James

AU - Olusanya, Temidayo

AU - Owens, Ashleigh J. S.

AU - Tseligka, Eirini D.

AU - Vizirianakis, Ioannis S.

AU - Tsibouklis, John

PY - 2017/10/8

Y1 - 2017/10/8

N2 - Boron neutron capture therapy (BNCT) is a non-conventional type of radio-chemotherapy that has been used to target a number of cancers, although predominantly brain tumours (gliomas). We report the co-spray- drying of o-carborane, as a model BNCT agent, with poly(vinylpyrrolidone) (PVP), a water-soluble polymer, to produce microparticle powders of high boron-content for BNCT treatment of liver and lung cancers. The powders have been characterised using NMR, particle sizing, electron microscopy and cytotoxicity tests. 1H NMR indicated the high temperatures (180 °C) of the spray drying process did not degrade the PVP. Mean particle diameters (x90 ) were in the 2–10 µm range, with finer fractions being present (x10 ≅ 1–2 µm), and were therefore considered suitable size for delivery to the lungs. SEM imaging showed particles to be spherical, with dimples and cavities, caused by the spray drier nozzle characteristics, and similarly sized irregularly-shaped crystalline particles, thought to be o-carborane. Boron chemical mapping was attempted using EDS, although the low atomic weight of boron did not allow this to be possible. Cytotoxicity studies, using neoplastic (human glioblastoma U-87 MG) and non-neoplastic (human fetal lung fibroblast MRC-5) cells, revealed the PVP/o-carborane co-spray- dried particles to be non-toxic, as expected.

AB - Boron neutron capture therapy (BNCT) is a non-conventional type of radio-chemotherapy that has been used to target a number of cancers, although predominantly brain tumours (gliomas). We report the co-spray- drying of o-carborane, as a model BNCT agent, with poly(vinylpyrrolidone) (PVP), a water-soluble polymer, to produce microparticle powders of high boron-content for BNCT treatment of liver and lung cancers. The powders have been characterised using NMR, particle sizing, electron microscopy and cytotoxicity tests. 1H NMR indicated the high temperatures (180 °C) of the spray drying process did not degrade the PVP. Mean particle diameters (x90 ) were in the 2–10 µm range, with finer fractions being present (x10 ≅ 1–2 µm), and were therefore considered suitable size for delivery to the lungs. SEM imaging showed particles to be spherical, with dimples and cavities, caused by the spray drier nozzle characteristics, and similarly sized irregularly-shaped crystalline particles, thought to be o-carborane. Boron chemical mapping was attempted using EDS, although the low atomic weight of boron did not allow this to be possible. Cytotoxicity studies, using neoplastic (human glioblastoma U-87 MG) and non-neoplastic (human fetal lung fibroblast MRC-5) cells, revealed the PVP/o-carborane co-spray- dried particles to be non-toxic, as expected.

KW - boron neutron capture therapy

KW - BNCT

KW - cancer

KW - carborane

KW - formulation

KW - spray drying

UR - http://www.jipbs.com/AboutUs.aspx

M3 - Article

VL - 4

SP - 9

EP - 15

JO - Journal of Innovations in Pharmaceutical and Biological Sciences

JF - Journal of Innovations in Pharmaceutical and Biological Sciences

SN - 2395-1095

IS - 4

ER -

ID: 7888545