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Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation

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Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation. / Verestiuc, L.; Nastasescu, O.; Barbu, Eugen; Sarvaiya, I.; Green, K.; Tsibouklis, John.

In: Journal of Biomedical Materials Research Part A, Vol. 77A, No. 4, 2006, p. 726-735.

Research output: Contribution to journalArticle

Harvard

Verestiuc, L, Nastasescu, O, Barbu, E, Sarvaiya, I, Green, K & Tsibouklis, J 2006, 'Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation', Journal of Biomedical Materials Research Part A, vol. 77A, no. 4, pp. 726-735. https://doi.org/10.1002/jbm.a.30668

APA

Verestiuc, L., Nastasescu, O., Barbu, E., Sarvaiya, I., Green, K., & Tsibouklis, J. (2006). Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation. Journal of Biomedical Materials Research Part A, 77A(4), 726-735. https://doi.org/10.1002/jbm.a.30668

Vancouver

Author

Verestiuc, L. ; Nastasescu, O. ; Barbu, Eugen ; Sarvaiya, I. ; Green, K. ; Tsibouklis, John. / Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation. In: Journal of Biomedical Materials Research Part A. 2006 ; Vol. 77A, No. 4. pp. 726-735.

Bibtex

@article{2bfea0ea07984ebcaf9654c96edd1e57,
title = "Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation",
abstract = "A series of hybrid polymeric hydrogels, prepared by the reaction of acrylic acid-functionalized chitosan with either N-isopropylacrylamide or 2-hydroxyethyl methacrylate monomers, were synthesized, pressed into minitablets, and investigated for their ability to act as controlled release vehicles for ophthalmic drug delivery. For comparison, interpolymeric complex analogues synthesized using the same monomers and pure, unfunctionalized chitosan were examined by means of an identical characterization protocol. The effects of network structure and composition upon the swelling properties, adhesion behavior, and drug release characteristics were investigated. Comparative in vitro studies employing chloramphenicol, atropine, norfloxacin, or pilocarpine informed the selection of drug-specific carrier compositions for the controlled delivery of these compounds. In addition, in vivo (rabbit model) experiments involving the delivery of pilocarpine indicated that chitosan-based hybrid polymer networks containing 2-hydroxyethyl methacrylate are useful carriers for the delivery of this therapeutic agent.",
author = "L. Verestiuc and O. Nastasescu and Eugen Barbu and I. Sarvaiya and K. Green and John Tsibouklis",
year = "2006",
doi = "10.1002/jbm.a.30668",
language = "English",
volume = "77A",
pages = "726--735",
journal = "Journal of Biomedical Materials Research Part A",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation

AU - Verestiuc, L.

AU - Nastasescu, O.

AU - Barbu, Eugen

AU - Sarvaiya, I.

AU - Green, K.

AU - Tsibouklis, John

PY - 2006

Y1 - 2006

N2 - A series of hybrid polymeric hydrogels, prepared by the reaction of acrylic acid-functionalized chitosan with either N-isopropylacrylamide or 2-hydroxyethyl methacrylate monomers, were synthesized, pressed into minitablets, and investigated for their ability to act as controlled release vehicles for ophthalmic drug delivery. For comparison, interpolymeric complex analogues synthesized using the same monomers and pure, unfunctionalized chitosan were examined by means of an identical characterization protocol. The effects of network structure and composition upon the swelling properties, adhesion behavior, and drug release characteristics were investigated. Comparative in vitro studies employing chloramphenicol, atropine, norfloxacin, or pilocarpine informed the selection of drug-specific carrier compositions for the controlled delivery of these compounds. In addition, in vivo (rabbit model) experiments involving the delivery of pilocarpine indicated that chitosan-based hybrid polymer networks containing 2-hydroxyethyl methacrylate are useful carriers for the delivery of this therapeutic agent.

AB - A series of hybrid polymeric hydrogels, prepared by the reaction of acrylic acid-functionalized chitosan with either N-isopropylacrylamide or 2-hydroxyethyl methacrylate monomers, were synthesized, pressed into minitablets, and investigated for their ability to act as controlled release vehicles for ophthalmic drug delivery. For comparison, interpolymeric complex analogues synthesized using the same monomers and pure, unfunctionalized chitosan were examined by means of an identical characterization protocol. The effects of network structure and composition upon the swelling properties, adhesion behavior, and drug release characteristics were investigated. Comparative in vitro studies employing chloramphenicol, atropine, norfloxacin, or pilocarpine informed the selection of drug-specific carrier compositions for the controlled delivery of these compounds. In addition, in vivo (rabbit model) experiments involving the delivery of pilocarpine indicated that chitosan-based hybrid polymer networks containing 2-hydroxyethyl methacrylate are useful carriers for the delivery of this therapeutic agent.

U2 - 10.1002/jbm.a.30668

DO - 10.1002/jbm.a.30668

M3 - Article

VL - 77A

SP - 726

EP - 735

JO - Journal of Biomedical Materials Research Part A

JF - Journal of Biomedical Materials Research Part A

SN - 1549-3296

IS - 4

ER -

ID: 143173