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‘Give-up-itis’ revisited: neuropathology of extremis

Research output: Contribution to journalArticle

The term ‘give-up-itis’ describes people who respond to traumatic stress by developing extreme apathy, give up hope, relinquish the will to live and die, despite no obvious organic cause. This paper discusses the nature of give-up-itis, with progressive demotivation and executive dysfunction that have clinical analogues suggesting frontal-subcortical circuit dysfunction particularly within the dorsolateral prefrontal and anterior cingulate circuits. It is hypothesised that progressive give-up-itis is consequent upon dopamine disequilibrium in these circuits, and a general theory for the cause and progression of give-up-itis is presented in which it is proposed that give-up-itis is the clinical expression of mental defeat; in particular, it is a pathology of a normal, passive coping response.
Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalMedical Hypotheses
Volume120
Early online date10 Aug 2018
DOIs
Publication statusPublished - Nov 2018

Documents

  • Leach_GUI_revisited

    Accepted author manuscript (Post-print), 679 KB, PDF-document

    Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 10/08/19

    Licence: CC BY-NC-ND

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