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‘Give-up-itis’ revisited: neuropathology of extremis

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‘Give-up-itis’ revisited: neuropathology of extremis. / Leach, John.

In: Medical Hypotheses, Vol. 120, 11.2018, p. 14-21.

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Leach, John. / ‘Give-up-itis’ revisited: neuropathology of extremis. In: Medical Hypotheses. 2018 ; Vol. 120. pp. 14-21.

Bibtex

@article{1ba3ff2086a24701b6fd776061f3191e,
title = "‘Give-up-itis’ revisited: neuropathology of extremis",
abstract = "The term ‘give-up-itis’ describes people who respond to traumatic stress by developing extreme apathy, give up hope, relinquish the will to live and die, despite no obvious organic cause. This paper discusses the nature of give-up-itis, with progressive demotivation and executive dysfunction that have clinical analogues suggesting frontal-subcortical circuit dysfunction particularly within the dorsolateral prefrontal and anterior cingulate circuits. It is hypothesised that progressive give-up-itis is consequent upon dopamine disequilibrium in these circuits, and a general theory for the cause and progression of give-up-itis is presented in which it is proposed that give-up-itis is the clinical expression of mental defeat; in particular, it is a pathology of a normal, passive coping response.",
keywords = "Death and dying, Neuropsychology, Psychopathology, Psychological stress",
author = "John Leach",
year = "2018",
month = "11",
doi = "10.1016/j.mehy.2018.08.009",
language = "English",
volume = "120",
pages = "14--21",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - ‘Give-up-itis’ revisited: neuropathology of extremis

AU - Leach, John

PY - 2018/11

Y1 - 2018/11

N2 - The term ‘give-up-itis’ describes people who respond to traumatic stress by developing extreme apathy, give up hope, relinquish the will to live and die, despite no obvious organic cause. This paper discusses the nature of give-up-itis, with progressive demotivation and executive dysfunction that have clinical analogues suggesting frontal-subcortical circuit dysfunction particularly within the dorsolateral prefrontal and anterior cingulate circuits. It is hypothesised that progressive give-up-itis is consequent upon dopamine disequilibrium in these circuits, and a general theory for the cause and progression of give-up-itis is presented in which it is proposed that give-up-itis is the clinical expression of mental defeat; in particular, it is a pathology of a normal, passive coping response.

AB - The term ‘give-up-itis’ describes people who respond to traumatic stress by developing extreme apathy, give up hope, relinquish the will to live and die, despite no obvious organic cause. This paper discusses the nature of give-up-itis, with progressive demotivation and executive dysfunction that have clinical analogues suggesting frontal-subcortical circuit dysfunction particularly within the dorsolateral prefrontal and anterior cingulate circuits. It is hypothesised that progressive give-up-itis is consequent upon dopamine disequilibrium in these circuits, and a general theory for the cause and progression of give-up-itis is presented in which it is proposed that give-up-itis is the clinical expression of mental defeat; in particular, it is a pathology of a normal, passive coping response.

KW - Death and dying

KW - Neuropsychology

KW - Psychopathology

KW - Psychological stress

U2 - 10.1016/j.mehy.2018.08.009

DO - 10.1016/j.mehy.2018.08.009

M3 - Article

VL - 120

SP - 14

EP - 21

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

ER -

ID: 11212887