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Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity

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Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity. / Saynor, Zoe Louise; Barker, Alan Robert; Oades, Patrick John; Williams, Craig Anthony.

In: Medicine and Science in Sports & Exercise, Vol. 48, No. 11, 11.2016, p. 2090-2099.

Research output: Contribution to journalArticle

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Saynor, ZL, Barker, AR, Oades, PJ & Williams, CA 2016, 'Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity', Medicine and Science in Sports & Exercise, vol. 48, no. 11, pp. 2090-2099. https://doi.org/10.1249/MSS.0000000000001004

APA

Saynor, Z. L., Barker, A. R., Oades, P. J., & Williams, C. A. (2016). Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity. Medicine and Science in Sports & Exercise, 48(11), 2090-2099. https://doi.org/10.1249/MSS.0000000000001004

Vancouver

Saynor ZL, Barker AR, Oades PJ, Williams CA. Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity. Medicine and Science in Sports & Exercise. 2016 Nov;48(11):2090-2099. https://doi.org/10.1249/MSS.0000000000001004

Author

Saynor, Zoe Louise ; Barker, Alan Robert ; Oades, Patrick John ; Williams, Craig Anthony. / Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity. In: Medicine and Science in Sports & Exercise. 2016 ; Vol. 48, No. 11. pp. 2090-2099.

Bibtex

@article{594c8f678f224a0880810e9d23356453,
title = "Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity",
abstract = "Purpose - To investigate the effects of mild-to-moderate cystic fibrosis (CF) on the pulmonary oxygen uptake (VO2) kinetics of 7 pediatric patients (13.5 +/- 2.8 y) versus 7 healthy matched controls (CON; 13.6 +/- 2.4 y). We hypothesized that CF would slow the VO2 kinetic response at the onset of moderate (MOD) and very heavy (VH) intensity cycling.Methods - Changes in breath-by-breath VO2, near-infrared spectroscopy-derived muscle deoxygenation ([HHb]) at the m. vastus lateralis and thoracic bioelectrical impedance-derived heart rate, stroke volume index (SVI) and cardiac index (CI) were measured during repeat transitions to MOD (90% of the gas exchange threshold) and VH (Δ60%) intensity cycling exercise.Results - During MOD, the phase II VO2 [tau] (p=0.84; effect size (ES) = 0.11) and overall mean response time (MRT) (p=0.52; ES=0.11) were not significantly slower in CF versus CON. However, during VH exercise, the phase II VO2 [tau] (p=0.02, ES=1.28) and MRT (p=0.01, ES=1.40) were significantly slower in CF. Cardiac function, central O2 delivery (SVI and CI) and muscle [HHb] kinetics were unaltered in CF. However, the arterial-venous O2 content difference (C(a-)VO2) was reduced during VH at 30 s (p=0.03, ES=0.37), with a trend for reduced levels at 0 s (p=0.07, ES=0.25), 60 s (p=0.05, ES=0.28) and 120 s (p=0.07, ES=0.25) in CF. Furthermore, ΔC(a-)VO2 significantly correlated with the VH phase II VO2 [tau] (r= -0.85; p=0.02) and MRT (r = -0.79; p=0.03) in CF only.Conclusion - Impairments in muscle oxidative metabolism during constant work rate exercise are intensity-dependent in young people with mild-to-moderate CF. Specifically, VO2 kinetics are slowed during VH but not MOD cycling and appear to be mechanistically linked to impaired muscle O2 extraction and utilization.",
keywords = "oxidative muscle metabolism, pulmonary disease, near-infrared spectroscopy, oxygen delivery, pediatrics",
author = "Saynor, {Zoe Louise} and Barker, {Alan Robert} and Oades, {Patrick John} and Williams, {Craig Anthony}",
year = "2016",
month = nov,
doi = "10.1249/MSS.0000000000001004",
language = "English",
volume = "48",
pages = "2090--2099",
journal = "Medicine and Science in Sports & Exercise",
issn = "0195-9131",
publisher = "Lippincott, Williams and Wilkins",
number = "11",

}

RIS

TY - JOUR

T1 - Impaired pulmonary VO2 kinetics in cystic fibrosis depend on exercise intensity

AU - Saynor, Zoe Louise

AU - Barker, Alan Robert

AU - Oades, Patrick John

AU - Williams, Craig Anthony

PY - 2016/11

Y1 - 2016/11

N2 - Purpose - To investigate the effects of mild-to-moderate cystic fibrosis (CF) on the pulmonary oxygen uptake (VO2) kinetics of 7 pediatric patients (13.5 +/- 2.8 y) versus 7 healthy matched controls (CON; 13.6 +/- 2.4 y). We hypothesized that CF would slow the VO2 kinetic response at the onset of moderate (MOD) and very heavy (VH) intensity cycling.Methods - Changes in breath-by-breath VO2, near-infrared spectroscopy-derived muscle deoxygenation ([HHb]) at the m. vastus lateralis and thoracic bioelectrical impedance-derived heart rate, stroke volume index (SVI) and cardiac index (CI) were measured during repeat transitions to MOD (90% of the gas exchange threshold) and VH (Δ60%) intensity cycling exercise.Results - During MOD, the phase II VO2 [tau] (p=0.84; effect size (ES) = 0.11) and overall mean response time (MRT) (p=0.52; ES=0.11) were not significantly slower in CF versus CON. However, during VH exercise, the phase II VO2 [tau] (p=0.02, ES=1.28) and MRT (p=0.01, ES=1.40) were significantly slower in CF. Cardiac function, central O2 delivery (SVI and CI) and muscle [HHb] kinetics were unaltered in CF. However, the arterial-venous O2 content difference (C(a-)VO2) was reduced during VH at 30 s (p=0.03, ES=0.37), with a trend for reduced levels at 0 s (p=0.07, ES=0.25), 60 s (p=0.05, ES=0.28) and 120 s (p=0.07, ES=0.25) in CF. Furthermore, ΔC(a-)VO2 significantly correlated with the VH phase II VO2 [tau] (r= -0.85; p=0.02) and MRT (r = -0.79; p=0.03) in CF only.Conclusion - Impairments in muscle oxidative metabolism during constant work rate exercise are intensity-dependent in young people with mild-to-moderate CF. Specifically, VO2 kinetics are slowed during VH but not MOD cycling and appear to be mechanistically linked to impaired muscle O2 extraction and utilization.

AB - Purpose - To investigate the effects of mild-to-moderate cystic fibrosis (CF) on the pulmonary oxygen uptake (VO2) kinetics of 7 pediatric patients (13.5 +/- 2.8 y) versus 7 healthy matched controls (CON; 13.6 +/- 2.4 y). We hypothesized that CF would slow the VO2 kinetic response at the onset of moderate (MOD) and very heavy (VH) intensity cycling.Methods - Changes in breath-by-breath VO2, near-infrared spectroscopy-derived muscle deoxygenation ([HHb]) at the m. vastus lateralis and thoracic bioelectrical impedance-derived heart rate, stroke volume index (SVI) and cardiac index (CI) were measured during repeat transitions to MOD (90% of the gas exchange threshold) and VH (Δ60%) intensity cycling exercise.Results - During MOD, the phase II VO2 [tau] (p=0.84; effect size (ES) = 0.11) and overall mean response time (MRT) (p=0.52; ES=0.11) were not significantly slower in CF versus CON. However, during VH exercise, the phase II VO2 [tau] (p=0.02, ES=1.28) and MRT (p=0.01, ES=1.40) were significantly slower in CF. Cardiac function, central O2 delivery (SVI and CI) and muscle [HHb] kinetics were unaltered in CF. However, the arterial-venous O2 content difference (C(a-)VO2) was reduced during VH at 30 s (p=0.03, ES=0.37), with a trend for reduced levels at 0 s (p=0.07, ES=0.25), 60 s (p=0.05, ES=0.28) and 120 s (p=0.07, ES=0.25) in CF. Furthermore, ΔC(a-)VO2 significantly correlated with the VH phase II VO2 [tau] (r= -0.85; p=0.02) and MRT (r = -0.79; p=0.03) in CF only.Conclusion - Impairments in muscle oxidative metabolism during constant work rate exercise are intensity-dependent in young people with mild-to-moderate CF. Specifically, VO2 kinetics are slowed during VH but not MOD cycling and appear to be mechanistically linked to impaired muscle O2 extraction and utilization.

KW - oxidative muscle metabolism

KW - pulmonary disease

KW - near-infrared spectroscopy

KW - oxygen delivery

KW - pediatrics

U2 - 10.1249/MSS.0000000000001004

DO - 10.1249/MSS.0000000000001004

M3 - Article

VL - 48

SP - 2090

EP - 2099

JO - Medicine and Science in Sports & Exercise

JF - Medicine and Science in Sports & Exercise

SN - 0195-9131

IS - 11

ER -

ID: 4142874