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In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions

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In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions. / Kockisch, Sandra; Rees, Gareth D.; Young, Simon A.; Tsibouklis, John; Smart, John D.

In: International Journal of Pharmaceutics, Vol. 276, No. 1-2, 19.05.2004, p. 51-58.

Research output: Contribution to journalArticle

Harvard

Kockisch, S, Rees, GD, Young, SA, Tsibouklis, J & Smart, JD 2004, 'In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions', International Journal of Pharmaceutics, vol. 276, no. 1-2, pp. 51-58. https://doi.org/10.1016/j.ijpharm.2004.02.020

APA

Kockisch, S., Rees, G. D., Young, S. A., Tsibouklis, J., & Smart, J. D. (2004). In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions. International Journal of Pharmaceutics, 276(1-2), 51-58. https://doi.org/10.1016/j.ijpharm.2004.02.020

Vancouver

Kockisch S, Rees GD, Young SA, Tsibouklis J, Smart JD. In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions. International Journal of Pharmaceutics. 2004 May 19;276(1-2):51-58. https://doi.org/10.1016/j.ijpharm.2004.02.020

Author

Kockisch, Sandra ; Rees, Gareth D. ; Young, Simon A. ; Tsibouklis, John ; Smart, John D. / In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions. In: International Journal of Pharmaceutics. 2004 ; Vol. 276, No. 1-2. pp. 51-58.

Bibtex

@article{44f6d521dae845b7adbadb5bcb2de4f6,
title = "In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions",
abstract = "The ability of polymeric microspheres fabricated from Carbopol, polycarbophil, chitosan or Gantrez to retain a model hydrophilic drug (sodium fluorescein) was evaluated in situ, using a dynamic test system and image analysis. This technique used oesophageal tissues and simulated the physiological conditions within the oral cavity in terms of temperature, humidity and saliva flow. The point of sample application was observed over a 2 h period by means of a digital camera. No significant differences in fluorescein colour intensity was obtained for the Gantrez and chitosan particles over 100 min, indicate that these two polymers provide the possibility of prolonged action. Carbopol and polycarbophil particles became rapidly swollen and released the sodium fluorescein completely within 20 min. It was concluded that the test system allowed the evaluation of the in situ behaviour of test particles, in terms of their ability to retain a water-soluble, coloured marker in 'dynamic' test conditions, and that chitosan and Gantrez were promising candidates for the production of mucoadhesive, sustained-release microspheres for water-soluble materials.",
keywords = "Bioadhesion, Chitosan, Maleic anhydride copolymers, Mucoadhesion, Oral cavity, Poly(acrylic acid)",
author = "Sandra Kockisch and Rees, {Gareth D.} and Young, {Simon A.} and John Tsibouklis and Smart, {John D.}",
year = "2004",
month = may,
day = "19",
doi = "10.1016/j.ijpharm.2004.02.020",
language = "English",
volume = "276",
pages = "51--58",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions

AU - Kockisch, Sandra

AU - Rees, Gareth D.

AU - Young, Simon A.

AU - Tsibouklis, John

AU - Smart, John D.

PY - 2004/5/19

Y1 - 2004/5/19

N2 - The ability of polymeric microspheres fabricated from Carbopol, polycarbophil, chitosan or Gantrez to retain a model hydrophilic drug (sodium fluorescein) was evaluated in situ, using a dynamic test system and image analysis. This technique used oesophageal tissues and simulated the physiological conditions within the oral cavity in terms of temperature, humidity and saliva flow. The point of sample application was observed over a 2 h period by means of a digital camera. No significant differences in fluorescein colour intensity was obtained for the Gantrez and chitosan particles over 100 min, indicate that these two polymers provide the possibility of prolonged action. Carbopol and polycarbophil particles became rapidly swollen and released the sodium fluorescein completely within 20 min. It was concluded that the test system allowed the evaluation of the in situ behaviour of test particles, in terms of their ability to retain a water-soluble, coloured marker in 'dynamic' test conditions, and that chitosan and Gantrez were promising candidates for the production of mucoadhesive, sustained-release microspheres for water-soluble materials.

AB - The ability of polymeric microspheres fabricated from Carbopol, polycarbophil, chitosan or Gantrez to retain a model hydrophilic drug (sodium fluorescein) was evaluated in situ, using a dynamic test system and image analysis. This technique used oesophageal tissues and simulated the physiological conditions within the oral cavity in terms of temperature, humidity and saliva flow. The point of sample application was observed over a 2 h period by means of a digital camera. No significant differences in fluorescein colour intensity was obtained for the Gantrez and chitosan particles over 100 min, indicate that these two polymers provide the possibility of prolonged action. Carbopol and polycarbophil particles became rapidly swollen and released the sodium fluorescein completely within 20 min. It was concluded that the test system allowed the evaluation of the in situ behaviour of test particles, in terms of their ability to retain a water-soluble, coloured marker in 'dynamic' test conditions, and that chitosan and Gantrez were promising candidates for the production of mucoadhesive, sustained-release microspheres for water-soluble materials.

KW - Bioadhesion

KW - Chitosan

KW - Maleic anhydride copolymers

KW - Mucoadhesion

KW - Oral cavity

KW - Poly(acrylic acid)

UR - http://www.scopus.com/inward/record.url?scp=2142808711&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2004.02.020

DO - 10.1016/j.ijpharm.2004.02.020

M3 - Article

C2 - 15113613

AN - SCOPUS:2142808711

VL - 276

SP - 51

EP - 58

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 11418987