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Inhibition of phosphatidylinositol phosphodiesterase activity in skeletal muscle by metal ions and drugs which block neuromuscular transmission

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The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.

Original languageEnglish
Pages (from-to)2471-2475
Number of pages5
JournalBiochemical Pharmacology
Issue number14
Publication statusPublished - 15 Jul 1985

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