Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation
Research output: Contribution to journal › Article › peer-review
Significance: This proof-of-concept approach was expected to provide an alternative formulation methodology for personalized mucoadhesive buccal films.
Methods: Mucoadhesive substrates were prepared by FDM and were subjected to sequential IP of an ibuprofen-loaded liquid ink. The interactions between these processes and the performance of the films were evaluated by various analytical and spectroscopic techniques, as well as by in vitro and ex vivo studies.
Results: The model drug was efficiently deposited by sequential IP passes onto the FDM-printed substrates. Significant variations were revealed on the morphological, physicochemical and mechanical properties of the prepared films, and linked to the number of IP passes. The mechanism of drug release, the mucoadhesion and the permeation of the drug through the buccal epithelium were evaluated, in view of the extent of ink deposition onto the buccal films, as well as the distribution of the API.
Conclusions: The presented methodology provided a proof-of-concept formulation approach for the development of personalized mucoadhesive films.
|Number of pages||12|
|Journal||Drug Development and Industrial Pharmacy|
|Early online date||1 Jul 2020|
|Publication status||Published - 2 Aug 2020|
- Inkjet printing of a thermolabile
Rights statement: This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 1/7/2020, available online: http://www.tandfonline.com/10.1080/03639045.2020.1788062.
Accepted author manuscript (Post-print), 1.92 MB, PDF document
Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 1/07/21